Other substances

ACE2‐TMPRSS2‐EVs

Vesicles carrying host ACE2 and TMPRSS2 as decoys for SARS-CoV-2 Spike protein.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Experimental

1
 Supporting references
0
 Contradictory references
0
 AI-suggested references
0
 Clinical trials

General information

ACE2‐TMPRSS2‐EVs are lipid bilayer-engulfed particles derived from human cells expressing ACE2 and TMPRSS2 on their surface. They are isolated using size-exlusion chromatography. ACE2-TMPRSS2-EVs can serve as a SARS-CoV-2 decoy (Cocozza et al., 2020).

Synonyms

ACE2-TMPRSS2-containing extracellular vesicles

 

Supporting references

Link Tested on Impact factor Notes Publication date
Extracellular vesicles containing ACE2 efficiently prevent infection by SARS‐CoV‐2 Spike protein‐containing virus
Spike protein ACE2 TMPRSS2 In vitro Mixed substance 		293FT‐ACE2 cells; Caco-2 cells; SARS-CoV-2 Spike pseudotyped virus 14.98

The extracellular vesicles containing ACE2 and TMPRSS2 on their surface partially prevented (serving as a decoy) SARS-CoV-2 Spike pseudovirus from infecting cells in a dose-dependent manner in vitro.

 Dec/28/2020
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