ACE2 receptor trap
An engineered protein binding the SARS-CoV-2 spike protein's RBD.
General information
An engineered ACE2 receptor fused with human IgG Fc with high affinity for the SARS-CoV-2 spike protein receptor-binding domain (Glasgow et al., 2020).
Supporting references
| Link | Tested on | Impact factor | Notes | Publication date |
|---|---|---|---|---|
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Engineered ACE2 receptor traps potently neutralize SARS-CoV-2
Spike protein Protein factor Enzyme assay In vitro |
in vitro binding assay; in vitro enzyme assay; HEK-ACE2 cells; SARS-CoV-2/CANADA/VIDO 01/2020 isolate | 9.41 | An engineered ACE2 receptor fused with human IgG Fc possesed 170-fold higher afinity to the SARS-CoV-2 spike preotein RBD compared to the wild type ACE2. It displayed potent SARS-CoV-2–pseudotyped lentivirus and authentic SARS-CoV-2 neutralizing activity in vitro. |
Oct/22/2020 |
