ACE2 microbody
A SARS-CoV-2 Spike protein binder.
General information
ACE2 microbody is composed of an inactive ACE2 ectodomain fused to the domain 3 of IgG heavy chain Fc. The fusion serves for ACE2 ectodomain dimerization (Tada et al., 2020).
Supporting references
| Link | Tested on | Impact factor | Notes | Publication date |
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An ACE2 Microbody Containing a Single Immunoglobulin Fc Domain Is a Potent Inhibitor of SARS-CoV-2
Spike protein ACE2 Protein factor Animal model In vitro Antibody |
ACE2.293T cells; K18-hACE2 mice; SARS-CoV-2 Spike protein pseudovirus; SARS-CoV-2 replication competent strain icSARS-CoV-2mNG; SARS-CoV-2 strain USA-WA1/2020 | 8.11 | The construct bound to Spike pseudotyped virus. It inhibited SARS-CoV-2 (pseudovirus/live virus) cell entry in vitro and protected hACE2 transgenic mice from viral infection (for both standard and D614G variant Spike protein). It displayed antiviral activity even when added 2 hours after a viral treatment in vitro. |
Dec/01/2020 |
AI-suggested references
| Link | Publication date |
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SARS CoV-2 Nucleoprotein Enhances the Infectivity of Lentiviral Spike Particles.
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Apr/23/2021 |
