Other substances

A-1H4

A SARS-CoV-2-neutralizing antibody.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Experimental

1
 Supporting references
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 Contradictory references
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 AI-suggested references
0
 Clinical trials

General information

A-1H4 is an IgG2/4 antibody with neutralizing activity against SARS-CoV-2 in vitro. It was identified using the phage display technique from an antibody library based on blood samples from infected patients (Kim et al., 2021).

 

Supporting references

Link Tested on Impact factor Notes Publication date
Stereotypic neutralizing VH antibodies against SARS-CoV-2 spike protein receptor binding domain in patients with COVID-19 and healthy individuals
Spike protein In vitro Antibody 		in vitro binding assay; Vero cells; SARS-CoV-2 isolate BetaCoV/Korea/SNU01/2020 16.30

The antibody (or a derived experimental construct) inhibited SARS-CoV-2 S protein binding to Vero E6 cells and it neutralized SARS-CoV-2 in Vero cells with ID50 of 0.439 μg/ml.

 Jan/27/2021
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