Other substances

Δ9-Tetrahydrocannabinol

A cannabinoid agonist.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Other treatment

Drug status

Used to treat other disease

2
 Supporting references
0
 Contradictory references
6
 AI-suggested references
176
 Clinical trials

General information

Δ9-Tetrahydrocannabinol is cannabinoid receptor agonist with analgesic, anti-emetic, and appetite stimulating properties (NCIt).

Δ9-Tetrahydrocannabinol on DrugBank
Δ9-Tetrahydrocannabinol on PubChem
Δ9-Tetrahydrocannabinol on Wikipedia

Synonyms

THC; Δ9-THC; Tetrahydrocannabinol

Marketed as

DRONABINOL; MARINOL; SYNDROS

 

Structure image - Δ9-Tetrahydrocannabinol

CCCCCC1=CC(=C2[C@@H]3C=C(CC[C@H]3C(OC2=C1)(C)C)C)O

Supporting references

Link Tested on Impact factor Notes Publication date
Δ9-Tetrahydrocannabinol Prevents Mortality from Acute Respiratory Distress Syndrome through the Induction of Apoptosis in Immune Cells, Leading to Cytokine Storm Suppression
ARDS Small molecule Animal model 		Staphylococcal enterotoxin B induced Acute Respiratory Distress Syndrome mouse (C3H) model 4.21

Theorised to alleviate ARDS in humans because in a mouse model of ARDS induced by Staphylococcal enterotoxin B the treatment with THC resulted in increased survival, decreased lung inflammation, and the suppression of cytokine storm. THC treatment caused downregulation of miR-185, which correlated with the observed increase in its pro-apoptic gene targets (of the mitochondrial pathway).

 Aug/28/2020
Assessment of antiviral potencies of cannabinoids against SARS-CoV-2 using computational and in vitro approaches
3CLpro Small molecule In vitro In silico 		in silico; Vero cells 5.16

Inhibited SARS-CoV-2 in vitro (IC50u202f=u202f10.25u202fμM in Vero cells).

 Dec/05/2020

AI-suggested references

Link Publication date
Activity of THC, CBD, and CBN on Human ACE2 and SARS-CoV1/2 Main Protease to Understand Antiviral Defense Mechanism.
Oct/12/2021
Study rationale and baseline data for pilot trial of dronabinol adjunctive treatment of agitation in Alzheimer's dementia (THC-AD).
Oct/11/2021
Delta9-Tetrahydrocannabinol Prevents Mortality from Acute Respiratory Distress Syndrome through the Induction of Apoptosis in Immune Cells, Leading to Cytokine Storm Suppression.
Aug/28/2020
A vaccine built from potential immunogenic pieces derived from the SARS-CoV-2 spike glycoprotein: A computational approximation
Oct/28/2021
Cannabinoids Alleviate the LPS-Induced Cytokine Storm via Attenuating NLRP3 Inflammasome Signaling and TYK2-Mediated STAT3 Signaling Pathways In Vitro
Aug/09/2021
Targeting of Protein's Messenger RNA for Viral Replication, Assembly and Release in SARS-CoV-2 Using Whole Genomic Data From South Africa: Therapeutic Potentials of Cannabis Sativa L
Apr/25/2022

Clinical trials

ID Title Status Phase Start date Completion date
NCT04569019 Attitudes Towards Influenza Vaccinations Among the Healthcare Workers of Medical University of Warsaw Recruiting Sep/01/2020 Jul/01/2022
  • Alternative id - AKBE/118/2020
  • Interventions - Other: Vacciantion status in health care workers
  • Study type - Observational
  • Study results - No Results Available
  • Locations - Warsaw Medical Uniwerity, Warsaw, Poland
  • Study designs - Observational Model: Case-Crossover|Time Perspective: Cross-Sectional
  • Enrollment - 1000
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Assesment of vaccination indeks in the hsopital by using questionare
NCT04469660 Impact of COVID-19 Pandemic on the Psychological Wellbeing of Healthcare Professionals in India Recruiting May/18/2020 Sep/30/2020
  • Alternative id - Onco Survey_COVID-19
  • Interventions -
  • Study type - Observational
  • Study results - No Results Available
  • Locations - Max Super Speciality Hospital Saket, New Delhi, Delhi, India
  • Study designs - Observational Model: Cohort|Time Perspective: Prospective
  • Enrollment - 1300
  • Age - 18 Years to 90 Years   (Adult, Older Adult)
  • Outcome measures - Therapeutic Sessions emphasizing on Stress|Resilience building and planning
NCT04551274 Music Therapy in Frontline Healthcare Workers Not yet recruiting Not Applicable Oct/01/2020 Nov/30/2020
  • Alternative id - H20-02015
  • Interventions - Behavioral: Music Therapy
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Simon Fraser University, Burnaby, British Columbia, Canada
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Single (Outcomes Assessor)|Primary Purpose: Supportive Care
  • Enrollment - 20
  • Age - 19 Years and older   (Adult, Older Adult)
  • Outcome measures - Change in Perceived Stress score - NIH Emotion Toolbox|Change in General Life Satisfaction score - NIH Emotion Toolbox|Change in Positive Affect score - NIH Emotion Toolbox|Change in Anger score - NIH Emotion Toolbox|Change in Fear score - NIH Emotion Toolbox|Change in Meaning & Purpose score - NIH Emotion Toolbox|Change in Sadness score - NIH Emotion Toolbox|Change in Emotional Support score - NIH Emotion Toolbox|Change in Loneliness score - NIH Emotion Toolbox|EEG - Change in power in the Delta band|EEG - Change in power in the Beta band|EEG - Change in power in the Alpha band|EEG - Change in power in the Theta band
NCT04342806 Healthcare Worker Exposure Response and Outcomes (HERO) Registry Study, COVID-19 Recruiting Apr/10/2020 Dec/31/2099
  • Alternative id - Pro00105284
  • Interventions -
  • Study type - Observational
  • Study results - No Results Available
  • Locations - Duke Clinical Research Institute, Durham, North Carolina, United States
  • Study designs - Observational Model: Cohort|Time Perspective: Prospective
  • Enrollment - 100000
  • Age - 18 Years to 110 Years   (Adult, Older Adult)
  • Outcome measures - Number and percent of participants who enroll in the HERO Registry Study by geographic region, age, COVID-19 risk factors, and past COVID-19 diagnosis|Distribution of COVID-19 risk factors by participant characteristics|Proportion of participants undergoing changes in health status (e.g. new diagnosis of COVID-19, ER visits, hospitalization)|Proportion of all participants enrolled in the HERO Registry who participate in an ancillary research study|Proportion of participants who continue to supply information about their health to the HERO Registry at various time points after their enrollment
NCT04646551 Covid-19 Risk Factors and Pattern Between Healthcare Workers Not yet recruiting Dec/01/2020 Jan/01/2022
  • Alternative id - Covid-19 patterrn
  • Interventions -
  • Study type - Observational
  • Study results - No Results Available
  • Locations -
  • Study designs - Observational Model: Other|Time Perspective: Other
  • Enrollment - 165
  • Age - 18 Years to 70 Years   (Adult, Older Adult)
  • Outcome measures - Assessment of the Pattern and Risk Factors of Covid-19 between infected Healthcare Workers
NCT04525417 Rapid Screening Test for Covid-19 Antibodies in Healthcare Workers Completed Not Applicable Apr/25/2020 Oct/25/2020
  • Alternative id - GERES20200409|ID RCB 2020-A01031-38
  • Interventions - Diagnostic Test: AAZ Covid-19 rapid test
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Bichat University Hospital, Paris, France
  • Study designs - Allocation: Non-Randomized|Intervention Model: Parallel Assignment|Masking: None (Open Label)|Primary Purpose: Diagnostic
  • Enrollment - 75
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - To assess the predictive value of Covid-19 rapid test|Compare the results of rapid tests on serum and capillary samples|A posteriori diagnosis of a covid-19 recent infection with suggestive symptomatology|Analysis of factors associated with negativity of PCR test on oropharyngeal swabs and positive serology
NCT04406571 Reorganization of the Healthcare System During COVID-19 Pandemic: Impact on Management of Patients With Exocrine Pancreatic Cancer Recruiting Apr/01/2020 Apr/01/2022
  • Alternative id - PO20042
  • Interventions - Other: Data record
  • Study type - Observational
  • Study results - No Results Available
  • Locations - Damien JOLLY, Reims, France
  • Study designs - Observational Model: Cohort|Time Perspective: Prospective
  • Enrollment - 700
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Pancreatic adenocarcinoma treatment
NCT04383587 Seroprevalence of SARS CoV 2 Antibodies in Previously Undiagnosed Healthcare Workers Completed Not Applicable May/06/2020 Jul/31/2020
  • Alternative id - 20-004054
  • Interventions - Other: Serologic testing
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Mayo Clinic in Florida, Jacksonville, Florida, United States
  • Study designs - Allocation: N/A|Intervention Model: Single Group Assignment|Masking: None (Open Label)|Primary Purpose: Health Services Research
  • Enrollment - 300
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Prevalence of COVID19 Antibody Positivity|Ability to predict immune status/antibody positivity
NCT05049187 Characterization and Durability of COVID-19 Vaccine Induced Immune Responses in Healthcare/Frontline Workers Recruiting May/21/2021 Aug/20/2023
  • Alternative id - 2021 007
  • Interventions -
  • Study type - Observational
  • Study results - No Results Available
  • Locations - National Institute for Research in Tuberculosis, Chennai, Tamilnadu, India
  • Study designs - Observational Model: Cohort|Time Perspective: Prospective
  • Enrollment - 150
  • Age - 18 Years to 60 Years   (Adult)
  • Outcome measures - Antibody titers|Ratio of immune biomarker production
NCT04844515 The ESPERES Prospective Cohort of Healthcare Workers in France: Study on COVID-19 Vaccine and the COVID-19 Pandemic (ESPERES_COVID19) Recruiting Apr/09/2021 Apr/23/2023
  • Alternative id - APHP210173.1
  • Interventions -
  • Study type - Observational
  • Study results - No Results Available
  • Locations - Pitié-Salpêtrière - Charles Foix, AP-HP, Paris, France
  • Study designs - Observational Model: Cohort|Time Perspective: Prospective
  • Enrollment - 15000
  • Age - 18 Years to 99 Years   (Adult, Older Adult)
  • Outcome measures - The COVID-19 vaccine intention with the question: "Do you intend to get vaccinated against COVID-19?" : I am already vaccinated / Yes, as soon as possible / Yes, but I prefer to wait before getting vaccinated / No, I don't think I'm gonna get vaccinated|The COVID-19 vaccine intention in HCWs participants according to the characteristics of the vaccines (country of the manufacturer, technology used, number of doses, etc.) and of the HCWs|Potential individual sociocognitive factors in the acceptance of COVID-19 vaccination, based on models developed for vaccine hesitation (5C psychological antecedents of vaccination adapted for COVID-19 vaccination and HCWs). (eleven points-Likert scales)|The perceptions of participants regarding the strategies for managing the pandemic and the progress of the health crisis and the pandemic (eleven points-Likert scales)|The healthy behaviors in other contexts (especially influenza vaccination over the last years)|The methods and sources of information concerning questions relating to health: media (website, social networks, television, radio or written press), nature (mainstream, classic or alternative media), etc.|Frequency of searches for information on COVID-19 or COVID-19 vaccines|Socio-demographic and professional characteristics, lifestyles: age, gender, profession and place of practice|The percentages of participants with history of COVID-19 and risk factors for severe forms of COVID-19 (perception of being at risk for severe forms)|The impact of the epidemic on the participants in their professional and personal life (closed-ended questions)|Contextual determinants: characteristic of living (density and constitution of the household) and work (type of hospital, working hours, time and mode of travel to workplace) places|Other health behaviors related to the COVID-19 pandemic: adherence to protective measures in professionnal and personal life during the last 14 days (eleven points-Likert scale)|The self-reported COVID-19 vaccine rate (dates, number of doses, type of vaccine, satisfaction)|Incidence of SARS-COV-2 infection (date, severity, mode of diagnosis, etc.)|The attitude of HCWs participants regarding the advice they give or not to patients, relatives and colleagues regarding the vaccination against COVID-19 (closed-ended questions)|Behavioral risk factors during the last 14 days before the SARS-COV-2 infection (closed-ended questions)|Other health behaviors related to the COVID-19 pandemic: the frequency of carrying out diagnostic tests for the infection to SARS-COV-2|The perceptions of participants in general regarding to the COVID-19 vaccination (eleven points-Likert scales)
NCT04510519 Scaling Mental Healthcare in COVID-19 With Voice Biomarkers Not yet recruiting Sep/01/2020 Jun/30/2021
  • Alternative id - COV-1
  • Interventions -
  • Study type - Observational
  • Study results - No Results Available
  • Locations -
  • Study designs - Observational Model: Cohort|Time Perspective: Prospective
  • Enrollment - 50
  • Age - 18 Years to 100 Years   (Adult, Older Adult)
  • Outcome measures - Patient Health Questionnaire (PHQ-9)|Generalized Anxiety Disorder (GAD-7)
NCT04331834 Pre-Exposure Prophylaxis With Hydroxychloroquine for High-Risk Healthcare Workers During the COVID-19 Pandemic Completed Phase 3 Apr/03/2020 Dec/31/2020
  • Alternative id - PrEP_COVID
  • Interventions - Drug: Hydroxychloroquine|Drug: Placebos
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - ISGlobal, Barcelona, Spain
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)|Primary Purpose: Prevention
  • Enrollment - 275
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Confirmed cases of a COVID-19|SARS-CoV-2 seroconversion|Occurrence of any adverse event related with hydroxychloroquine treatment|Incidence of SARS-CoV-2 infection and COVID-19 among healthcare workers|Risk ratio for the different clinical, analytical and microbiological conditions to develop COVID-19|COVID-19 Biobank
NCT04354597 Hydroxychloroquine and Azithromycin as Prophylaxis for Healthcare Workers Dealing With COVID19 Patients Withdrawn Not Applicable May/01/2020 Oct/15/2020
  • Alternative id - 20 KHCC 67
  • Interventions - Drug: HCQ & AZ
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - King Hussein Cancer Center, Amman, Jordan
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: None (Open Label)|Primary Purpose: Prevention
  • Enrollment - 0
  • Age - 25 Years to 70 Years   (Adult, Older Adult)
  • Outcome measures - Effect of HCQ and AZ in preventing infection with COVID-19 among healthcare workers working with COVID-19 patients|Safety of HCQ and AZ|Oxygen requirement|ICU admission|Mortality rate
NCT04424017 Sero-prevalence of Coronavirus Disease 2019 (COVID-19) in Healthcare Workers Completed Jun/07/2020 Oct/30/2020
  • Alternative id - COVID-19\004
  • Interventions - Biological: Specific anti-SARS-CoV-2 antibodies
  • Study type - Observational
  • Study results - No Results Available
  • Locations - ECRRM, Cairo, Egypt|Faculty of Medicine, Cairo University, Cairo, Egypt
  • Study designs - Observational Model: Other|Time Perspective: Cross-Sectional
  • Enrollment - 1546
  • Age - 18 Years to 60 Years   (Adult)
  • Outcome measures - Describe the serological status of individuals in the study by presence of specific anti-SARS-CoV-2 antibodies
NCT04373889 COVID-19 Among Healthcare Workers in Belgian Hospitals Completed Apr/22/2020 Apr/30/2021
  • Alternative id - Sciensano
  • Interventions -
  • Study type - Observational
  • Study results - No Results Available
  • Locations - Sciensano, Brussels, Belgium
  • Study designs - Observational Model: Cohort|Time Perspective: Prospective
  • Enrollment - 850
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Change of prevalence of COVID-19 infection among Belgian active hospital healthcare workers (HCW)|Change of seroprevalence of SARS-CoV-2 among Belgian active hospital HCW|Change in new cases (incidence) of COVID-19 among Belgian hospital HCW|Change in SARS-CoV-2 seroconversion among Belgian hospital HCW|Sensitivity and specificity of serological tests|Sensitivity and specificity of saliva sampling method (sampling with Oracol or equivalent)|Validate the nasal swab against the standard|Potential risk factors for the infection|The proportion of asymptomatic cases among new cases that develop during a period of 12 months
NCT04427865 Utility of Lactoferrin as a Preventive Agent for Healthcare Workers Exposed to COVID-19 Not yet recruiting Phase 2|Phase 3 Jul/01/2020 Nov/01/2020
  • Alternative id - CUKA-002
  • Interventions - Drug: prophylactic lactoferrin daily
  • Study type - Interventional
  • Study results - No Results Available
  • Locations -
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: None (Open Label)|Primary Purpose: Prevention
  • Enrollment - 200
  • Age - 18 Years to 65 Years   (Adult, Older Adult)
  • Outcome measures - Incidence of SARS-CoV-2|Severity of disease in confirmed infected participants
NCT04769297 Micro-Dose, Macro-Impact: Leveraging Psychedelics in Frontline Healthcare Workers During the COVID-19 Pandemic Active, not recruiting Phase 4 Apr/15/2020 Apr/01/2021
  • Alternative id - LM-LDK-001
  • Interventions - Drug: Sublingual Micro-Dose Ketamine
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Limbic Medical, Toluca Lake, California, United States
  • Study designs - Allocation: N/A|Intervention Model: Single Group Assignment|Masking: None (Open Label)|Primary Purpose: Treatment
  • Enrollment - 30
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Patient self-reported outcome measure
NCT04367857 ARMOR Study: COVID-19 Seroprevalence Among Healthcare Workers Recruiting Apr/18/2020 Jan/01/2022
  • Alternative id - AAAS9998
  • Interventions - Other: COVID-19 Serology|Behavioral: Health Care Worker Survey
  • Study type - Observational
  • Study results - No Results Available
  • Locations - NewYork-Presbyterian Hosptial/Columbia University Irving Medical Center, New York, New York, United States
  • Study designs - Observational Model: Cohort|Time Perspective: Prospective
  • Enrollment - 1000
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Proportion seropositive
NCT04473118 Assessment of Mental Health in Healthcare Workers Exposed to COVID-19 Patients Recruiting Jul/11/2020 Jun/01/2021
  • Alternative id - MRC-05-017
  • Interventions - Other: Survey
  • Study type - Observational
  • Study results - No Results Available
  • Locations - Hamad Medical Corporation, Doha, Qatar
  • Study designs - Observational Model: Cohort|Time Perspective: Prospective
  • Enrollment - 25000
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - To reflect the effect of COVID-19 on the burnout, anxiety, depression and stress levels of healthcare professionals during the COVID-19 crisis|To reflect the effect of COVID-19 on the post-trauma stress disorder levels of healthcare professionals following the COVID-19 crisis
NCT05057910 SARS-CoV-2 (Covid-19) RBD Antibody in My Duc Hospital Healthcare Workers Not yet recruiting Sep/25/2021 Oct/07/2021
  • Alternative id - 10/21/ĐĐ-BVMĐ
  • Interventions - Diagnostic Test: SARS-CoV-2 IgG II Quant
  • Study type - Observational
  • Study results - No Results Available
  • Locations - HOPE Research Center, My Duc Hospital, Ho Chi Minh City, Tan Binh, Vietnam
  • Study designs - Observational Model: Cohort|Time Perspective: Cross-Sectional
  • Enrollment - 735
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - SARS-CoV-2 anti-RBD IgG concentration
NCT05075018 Musculoskeletal Problems and Endurance in Healthcare Professionals With and Without COVID-19 Recruiting Sep/30/2021 Mar/20/2022
  • Alternative id - AIBU-FTR-ETY-02
  • Interventions - Other: Observational
  • Study type - Observational
  • Study results - No Results Available
  • Locations - Düzce Atatürk Devlet Hastanesi, Düzce, Turkey
  • Study designs - Observational Model: Other|Time Perspective: Prospective
  • Enrollment - 36
  • Age - 18 Years to 65 Years   (Adult, Older Adult)
  • Outcome measures - Measurement of the Endurance|Cornell Musculoskeletal Discomfort Questionnaire|Nottingham Health Profile|International Physical Activity Questionnaire|1 minute sit to stand test|Modified Borg Scale
NCT04854408 Evaluation of the Effect of Coronavac Vaccine (Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2 Vaccine) on Healthcare Workers' Menstrual Patterns Completed Mar/18/2021 May/09/2021
  • Alternative id - Coronavacendometrium
  • Interventions - Other: healthcare workers with the coronavac vaccine
  • Study type - Observational
  • Study results - No Results Available
  • Locations - Pinar Yalcin Bahat, Istanbul, İ̇stanbul, Turkey
  • Study designs - Observational Model: Other|Time Perspective: Prospective
  • Enrollment - 300
  • Age - 18 Years to 45 Years   (Adult)
  • Outcome measures - Possible effects of Coronavac vaccine (severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 vaccine) on menstrual cycle
NCT04360122 Levamisole and Isoprinosine in Immune-prophylaxis of Egyptian Healthcare Workers Facing COVID-19 Not yet recruiting Phase 3 May/20/2020 Dec/01/2020
  • Alternative id - FMASU P20a/ 2020
  • Interventions - Drug: Levamisole|Drug: Isoprinosine|Drug: Levamisole and Isoprinosine
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Faculty of Medicine Ain Shams University Research Institute- Clinical Research Center, Cairo, Non-US, Egypt
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: None (Open Label)|Primary Purpose: Prevention
  • Enrollment - 100
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Decrease the incidence of COVID-19 infection or its severity
NCT04642196 COVID-19 in Home Healthcare Completed May/02/2020 Oct/10/2020
  • Alternative id - Home healthcare 2020
  • Interventions -
  • Study type - Observational
  • Study results - No Results Available
  • Locations - Dept of anesthesia, Linköping, Sweden
  • Study designs - Observational Model: Cohort|Time Perspective: Retrospective
  • Enrollment - 155
  • Age - Child, Adult, Older Adult
  • Outcome measures - Frailty|Comorbidity
NCT05013047 Impact of the COVID-19 Pandemic on the Organization of Healthcare in France Recruiting Jul/01/2020 Dec/31/2022
  • Alternative id - 2021-13
  • Interventions -
  • Study type - Observational
  • Study results - No Results Available
  • Locations - Assistance Publique Hôpitaux de Marseille, Marseille, France
  • Study designs - Observational Model: Other|Time Perspective: Retrospective
  • Enrollment - 100000
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Assess the effect of pandemic COVID-19 on medication compliance in patients with chronic disease|Evaluate the effects of pandemic and lock-down on the risk of decompensation in patients with chronic disease.
NCT04574765 A Research Platform to Screen Healthcare Workers Recruiting Apr/16/2020 Apr/16/2021
  • Alternative id - OZUHN-001|20-5289
  • Interventions - Diagnostic Test: Nasopharyngeal swab|Other: Questionnaire collection|Other: Optional blood completion|Other: Optional questionnaire completion
  • Study type - Observational
  • Study results - No Results Available
  • Locations - University Health Network, Toronto, Ontario, Canada
  • Study designs - Observational Model: Cohort|Time Perspective: Prospective
  • Enrollment - 100000
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Percentage of healthcare workers who are asymptomatic and COVID-19 positive
NCT04858581 Prospective Clinical and Virological Analysis of Healthcare Workers Diagnosed Positive for Covid-19. Not yet recruiting Not Applicable Dec/01/2021 Dec/01/2023
  • Alternative id - 2020-A02720-39
  • Interventions - Diagnostic Test: Virological and serological tests
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Hopital privé d'Antony, Paris, France
  • Study designs - Allocation: N/A|Intervention Model: Single Group Assignment|Masking: None (Open Label)|Primary Purpose: Diagnostic
  • Enrollment - 100
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Description of symptoms attributed to COVID-19 at 6 months.
NCT04521010 Staff Absenteeism and Delivery of Healthcare Services During the COVID-19 Pandemic Completed Jan/01/2020 Apr/30/2020
  • Alternative id - 3/2020/Reh
  • Interventions - Other: COVID-19 pandemic
  • Study type - Observational
  • Study results - No Results Available
  • Locations - Department of Rehabilitation and Physiotherapy Rehabilitation,, Poznań, Poland
  • Study designs - Observational Model: Other|Time Perspective: Retrospective
  • Enrollment - 700
  • Age - Child, Adult, Older Adult
  • Outcome measures - Number of days an individual person was absent
NCT04961372 Socio-psychological Status of Healthcare Workers During SARS-CoV2 Pandemic Recruiting Mar/01/2021 Sep/30/2021
  • Alternative id - ErzincanUniversity
  • Interventions - Other: Survey
  • Study type - Observational
  • Study results - No Results Available
  • Locations - Siran Government Hospital, Gumushane, Siran, Turkey
  • Study designs - Observational Model: Ecologic or Community|Time Perspective: Prospective
  • Enrollment - 333
  • Age - 18 Years to 65 Years   (Adult, Older Adult)
  • Outcome measures - Patient Health Questionnaire-9 Score|Generalised Anxiety Disorder Assessment Score|Work and Social Adjustment Score
NCT05113472 Adverse Reactions Following COVID-19 Vaccination Among Ecuadorian Healthcare Workers Completed Mar/01/2021 May/31/2021
  • Alternative id - 2021-MED-001
  • Interventions - Biological: Pfizer-BioNTech COVID-19 vaccine
  • Study type - Observational
  • Study results - No Results Available
  • Locations - Universidad Espiritu Santo, Samborondon, Ecuador
  • Study designs - Observational Model: Cohort|Time Perspective: Cross-Sectional
  • Enrollment - 1291
  • Age - 18 Years to 99 Years   (Adult, Older Adult)
  • Outcome measures - Adverse reactions
NCT04363203 VA Remote and Equitable Access to COVID-19 Healthcare Delivery (VA-REACH TRIAL) Suspended Phase 3 Apr/30/2020 Aug/01/2021
  • Alternative id - 20-30517
  • Interventions - Drug: Hydroxychloroquine|Drug: Azithromycin|Drug: Placebo oral tablet
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - San Francisco VA, San Francisco, California, United States
  • Study designs - Allocation: Randomized|Intervention Model: Single Group Assignment|Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)|Primary Purpose: Treatment
  • Enrollment - 300
  • Age - 216 Months and older   (Adult, Older Adult)
  • Outcome measures - Days to resolution of cough, fever and shortness of breath|Days to resolution of all COVID-19 symptoms|All cause hospitalization|All cause mortality|COVID-19 specific mortality|COVID-19 specific hospitalization
NCT04497415 The COVID-19 and Healthcare Workers: An Active Intervention Completed Not Applicable Oct/21/2020 Jan/30/2021
  • Alternative id - 8032
  • Interventions - Other: Video-Based intervention
  • Study type - Interventional
  • Study results - Has Results
  • Locations - New York State Psychiatric Institute, New York, New York, United States
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Single (Participant)|Primary Purpose: Health Services Research
  • Enrollment - 350
  • Age - 18 Years to 80 Years   (Adult, Older Adult)
  • Outcome measures - Help-seeking Behavior|Generalized Anxiety Disorder-7 (GAD-7)|Patient Health Questionnaire-9 (PHQ-9)|Primary Care Posttraumatic Stress Disorder (PC-PTSD) Screen|Moral Injury Events Scale (MIES)
NCT04347889 Preventing COVID-19 in Healthcare Workers With HCQ: A RCT Withdrawn Phase 2 Apr/20/2020 Dec/30/2020
  • Alternative id - IRB2020-00222
  • Interventions - Drug: Hydroxychloroquine|Other: Vitamin C
  • Study type - Interventional
  • Study results - No Results Available
  • Locations -
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Single (Outcomes Assessor)|Primary Purpose: Prevention
  • Enrollment - 0
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - COVID-19 Seroconversion rate|Admission for Covid-19
NCT04474080 Reducing Burnout Among Frontline Healthcare Workers During COVID-19 Not yet recruiting Not Applicable Jan/15/2021 Jul/01/2021
  • Alternative id - 11136
  • Interventions - Behavioral: Virtual Peer Support Platform|Behavioral: Control Period
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - St. Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada
  • Study designs - Allocation: Randomized|Intervention Model: Crossover Assignment|Masking: None (Open Label)|Primary Purpose: Prevention
  • Enrollment - 1080
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Assess and measure overall burnout|Assess stress|Assess depression|Assess quality of life
NCT04437693 Post Exposure Prophylaxis in Healthcare Workers Exposed to COVID-19 Patients Not yet recruiting Phase 2|Phase 3 Aug/31/2020 Dec/31/2021
  • Alternative id - MRC-02-20-442
  • Interventions - Drug: Hydroxychloroquine
  • Study type - Interventional
  • Study results - No Results Available
  • Locations -
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Single (Participant)|Primary Purpose: Prevention
  • Enrollment - 500
  • Age - 18 Years to 60 Years   (Adult)
  • Outcome measures - Prevention of SARS-CoV-2 infection|Presence of any adverse effects related to HCQ|Incidence of COVID-19 related symptoms
NCT04445415 Diagnostic Value of New COVID-19 Antibodies Testing Among Laboratory Healthcare Workers Not yet recruiting Jul/01/2020 Sep/01/2021
  • Alternative id - COVID-19 antibodies testing
  • Interventions - Diagnostic Test: COVID-19 antibodies testing
  • Study type - Observational
  • Study results - No Results Available
  • Locations -
  • Study designs - Observational Model: Case-Only|Time Perspective: Retrospective
  • Enrollment - 250
  • Age - Child, Adult, Older Adult
  • Outcome measures - diagnostic value of COVID-19 antibodies testing|Role of COVID -19 Antibodies testing in treatment of Patients|Assement of COVID -19 prevalence among healthcare workers
NCT04477213 Risk Profiling of the Occupational Exposure of COVID-19 to Healthcare Workers. Completed Sep/11/2021 Oct/02/2021
  • Alternative id - NMCHCW-COVID
  • Interventions -
  • Study type - Observational
  • Study results - No Results Available
  • Locations - NMC Specialty Hospital, Al Nahda, Dubai, United Arab Emirates
  • Study designs - Observational Model: Cohort|Time Perspective: Prospective
  • Enrollment - 286
  • Age - 18 Years to 70 Years   (Adult, Older Adult)
  • Outcome measures - Rate of COVID-19 in healthcare workers (HCWs)|clinical severity of infection in HCWs
NCT04425889 COVID-19 Antibodies Among Healthcare Workers Completed May/05/2020 Jun/01/2020
  • Alternative id - IF20-00008
  • Interventions - Diagnostic Test: COVID-19 IgG/IgM Rapid Test Cassette test (Healgen Scientific, Houston, Texas, USA)
  • Study type - Observational
  • Study results - No Results Available
  • Locations - Hospital Universitario José E. Gonzalez, Monterrey, Nuevo Leon, Mexico
  • Study designs - Observational Model: Cohort|Time Perspective: Cross-Sectional
  • Enrollment - 156
  • Age - 18 Years to 99 Years   (Adult, Older Adult)
  • Outcome measures - Presence of antibody
NCT04535791 Efficacy of Vitamin D Supplementation to Prevent the Risk of Acquiring COVID-19 in Healthcare Workers Completed Phase 3 Jul/15/2020 Jul/15/2021
  • Alternative id - R-2020-785-090
  • Interventions - Drug: Cholecalciferol
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Hospital Centro Medico Nacional Siglo XXI, Mexico City, Distrito Federal, Mexico
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Triple (Participant, Care Provider, Investigator)|Primary Purpose: Treatment
  • Enrollment - 321
  • Age - 18 Years to 70 Years   (Adult, Older Adult)
  • Outcome measures - Number of Participants with COVID-19|Number of Participants with hospitalization for COVID-19|Serum concentration of 25 (OH) vitamin D
NCT04363489 The CEDiD Study (COVID-19 Early Diagnosis in Doctors and Healthcare Workers) Recruiting Aug/20/2020 Jun/30/2021
  • Alternative id - CEDiD Study
  • Interventions - Device: Wearable Medical Device (Empatica E4)|Diagnostic Test: COVID-19 PCR Swab|Diagnostic Test: Pulse Oximeter
  • Study type - Observational
  • Study results - No Results Available
  • Locations - Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom
  • Study designs - Observational Model: Cohort|Time Perspective: Prospective
  • Enrollment - 60
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - COVID-19 Infection|Symptoms|Clinical Observations
NCT04853004 Current and Past SARS-CoV-2 Infection and COVID-19 in Healthcare With Regard to Vaccinations Enrolling by invitation Apr/01/2021 Mar/01/2023
  • Alternative id - Covid19_7
  • Interventions - Diagnostic Test: SARS-CoV2 antibody measurement
  • Study type - Observational
  • Study results - No Results Available
  • Locations - Karolinska University Hospital, Stockholm, Sweden
  • Study designs - Observational Model: Cohort|Time Perspective: Prospective
  • Enrollment - 10000
  • Age - 18 Years to 99 Years   (Adult, Older Adult)
  • Outcome measures - SARS-CoV-2 infection|SARS-CoV-2 antibody induction
NCT05209178 Diagnostic Accuracy of Self-sampling Versus Healthcare Sampling for Coronavirus-Disease-2019 Detection. Not yet recruiting Not Applicable Jan/17/2022 Feb/11/2022
  • Alternative id - CVB2022 - CoV2 selftest
  • Interventions - Diagnostic Test: Self-collection of nasal specimen for COVID19 antigen test
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet-Copenhagen University Hospital, Copenhagen, Denmark
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: None (Open Label)|Primary Purpose: Diagnostic
  • Enrollment - 5000
  • Age - 16 Years and older   (Child, Adult, Older Adult)
  • Outcome measures - Sensitivity of the self-collected rapid antigen test compared to healthcare collected test|Accuracy of self-collection and healthcare collected rapid antigen test to RT-PCR|Validity of RT-PCR analysis of left-over material from rapid antigen tests
NCT04364802 COVID-19: Povidone-Iodine Intranasal Prophylaxis in Front-line Healthcare Personnel and Inpatients Recruiting Phase 2 Apr/29/2020 Apr/01/2022
  • Alternative id - 58748
  • Interventions - Drug: Povidone-Iodine Nasal Spray and Gargle
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - University of Kentucky, Lexington, Kentucky, United States
  • Study designs - Allocation: Non-Randomized|Intervention Model: Parallel Assignment|Masking: None (Open Label)|Primary Purpose: Prevention
  • Enrollment - 300
  • Age - 18 Years to 99 Years   (Adult, Older Adult)
  • Outcome measures - Percent of healthcare workers testing positive for COVID-19.|Percent of patients testing positive for COVID-9.|Percent of community participants testing positive for COVID-9.|PVP-I Ease of Use|PVP-I Comfort
NCT04350099 Emotional Burden of Healthcare Professionals and Covid Infection 19 Recruiting Apr/15/2020 Jun/15/2021
  • Alternative id - 87RI20_0015/Emocovid
  • Interventions - Other: quetionnary
  • Study type - Observational
  • Study results - No Results Available
  • Locations - CH Esquirol, Limoges, France|CHU de Limoges, Limoges, France|HCL LYON, Lyon, France
  • Study designs - Observational Model: Cohort|Time Perspective: Prospective
  • Enrollment - 200
  • Age - Child, Adult, Older Adult
  • Outcome measures - anxiety
NCT04395300 Sleep Quality in Healthcare Personnel During COVID-19 Completed Mar/30/2020 May/16/2020
  • Alternative id - AssiutU14
  • Interventions - Other: Web Based Survey
  • Study type - Observational
  • Study results - No Results Available
  • Locations - AssiutU, Assiut, Egypt
  • Study designs - Observational Model: Ecologic or Community|Time Perspective: Cross-Sectional
  • Enrollment - 143
  • Age - 18 Years to 80 Years   (Adult, Older Adult)
  • Outcome measures - measure sleep quality in healthcare worker|impact of covid-19 pandemic on general health|correlate between sleep quality and general health
NCT04387409 Study to Assess VPM1002 in Reducing Healthcare Professionals' Absenteeism in COVID-19 Pandemic Active, not recruiting Phase 3 May/25/2020 May/01/2021
  • Alternative id - VPM1002-DE-3.06CoV
  • Interventions - Biological: VPM1002|Biological: Placebo
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Ludwig-Maximilians-Universität München, München, Bayern, Germany|Medizinische Hochschule Hannover, Hannover, Niedersachsen, Germany|SocraTec R&D GmbH, Erfurt, Thüringen, Germany
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Triple (Participant, Investigator, Outcomes Assessor)|Primary Purpose: Prevention
  • Enrollment - 59
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Number of days absent from work due to respiratory disease (with or without documented SARS-CoV-2 infection)|Cumulative incidence of documented SARS-CoV-2 infection|Number of days absent from work due to documented SARS-CoV-2 infection|Number of days absent from work due to exposure to person with documented SARS-CoV-2 infection|Number of days absent from work due to symptoms of respiratory disease, documented SARS-CoV-2 infection, or fever (≥ 38 °C)|Number of days of self-reported fever (≥ 38 °C)|Number of days of self-reported acute respiratory symptoms|Cumulative incidence of self-reported acute respiratory symptoms|Cumulative incidence of death for any reason|Cumulative incidence of death due to documented SARS-CoV-2 infection|Cumulative incidence of ICU admission for any reason|Cumulative incidence of ICU admission due to documented SARS-CoV-2 infection|Cumulative incidence of hospital admission for any reason|Cumulative incidence of hospital admission due to documented SARS-CoV-2 infection
NCT04694651 Potential Acceptance of COVID-19 Vaccines in Healthcare Workers in Egypt Recruiting Dec/15/2020 Feb/15/2021
  • Alternative id - AssiutU18
  • Interventions -
  • Study type - Observational
  • Study results - No Results Available
  • Locations - AssiutU, Assiut, Egypt|Aliae AR Mohamed-Hussein, Assiut, Egypt
  • Study designs - Observational Model: Cohort|Time Perspective: Prospective
  • Enrollment - 400
  • Age - 18 Years to 80 Years   (Adult, Older Adult)
  • Outcome measures - Measure frequency of acceptance of vaccination|Describe causes of refusal of vaccination
NCT04890665 Online Multi-component Psychological Intervention for Healthcare Workers During COVID-19 Pandemic Recruiting Not Applicable Jul/16/2021 Jun/20/2022
  • Alternative id - VIU-Health_care_workers_COVID
  • Interventions - Behavioral: Online psychological intervention for healthcare workers
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Universidad Autónoma de Ciudad Juárez, Juarez, Chihuahua, Mexico|Universidad de Guadalajara, Guadalajara, Jalisco, Mexico|Universidad Nacional Autónoma de México, Mexico, Mexico
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Single (Participant)|Primary Purpose: Treatment
  • Enrollment - 42
  • Age - 18 Years to 65 Years   (Adult, Older Adult)
  • Outcome measures - The Center for Epidemiologic Studies Depression Scale-Revised (CESD-R)|Decrease in the symptoms of General Anxiety Disorder (GAD-7)|Decrease in the score of The Pittsburgh Sleep Quality Index (PSQI).|Decrease in the scores of the Post-Traumatic Stress Disorder Symptom Scale (PSS)|Increase in the score of the Professional Quality of Life Measure (ProQOL)|Increase in the score of the Appraisal of Self-care Agency (ASA)|Decrease in the Plutchik Suicide Risk Scale (BSI)|Increase in the Scale for measuring resilience with Mexicans (RESI-M)
NCT04625296 Behaviour and Experience of Communities Healthcare Professionals Facing the SARS CoV-2 (COVID-19) Epidemic Completed Sep/17/2020 Jan/12/2021
  • Alternative id - AP-HP 200512
  • Interventions - Behavioral: Semi-directive interview|Behavioral: Questionnaire : Preparedness for Caregiving Scale
  • Study type - Observational
  • Study results - No Results Available
  • Locations - URC/CIC Paris Centre, Paris, France
  • Study designs - Observational Model: Cohort|Time Perspective: Prospective
  • Enrollment - 62
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Diversity of themes extracted about care situations management of the COVID-19 epidemic.|Preparedness for caregiving scale (PCS)
NCT04377646 A Study of Hydroxychloroquine and Zinc in the Prevention of COVID-19 Infection in Military Healthcare Workers Not yet recruiting Phase 3 May/04/2020 Jul/31/2020
  • Alternative id - UR17DN02-001|TN2020-NAT-INS-38
  • Interventions - Drug: Hydroxychloroquine|Drug: Hydroxychloroquine (placebo)|Drug: Zinc|Drug: Zinc (Placebo)
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Military Hospital of Tunis, Tunis, Tunisia
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Triple (Participant, Care Provider, Investigator)|Primary Purpose: Prevention
  • Enrollment - 660
  • Age - 18 Years to 65 Years   (Adult, Older Adult)
  • Outcome measures - SARS CoV2 infection|COVID-19 symptoms description|Adverse Events
NCT04318015 Hydroxychloroquine Chemoprophylaxis in Healthcare Personnel in Contact With COVID-19 Patients (PHYDRA Trial) Completed Phase 3 Apr/14/2020 Mar/31/2021
  • Alternative id - ProfilaxisCOVID
  • Interventions - Drug: Hydroxychloroquine|Drug: Placebo oral tablet
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Instituto Nacional de Enfermedades Respiratorias, "Ismael Cosío Villegas", Mexico, City, Mexico
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)|Primary Purpose: Prevention
  • Enrollment - 289
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Symptomatic COVID-19 infection rate|Symptomatic non-COVID viral infection rate|Days of labor absenteeism|Rate of labor absenteeism|Rate of severe respiratory COVID-19 disease in healthcare personnel
NCT04371926 Prophylactic Benefit of Hydroxychloroquine in COVID-19 Cases With Mild to Moderate Symptoms and in Healthcare Workers With High Exposure Risk Withdrawn Not Applicable Jun/01/2020 Jul/01/2021
  • Alternative id - TCAI_PREVENT
  • Interventions - Drug: Hydroxychloroquine Sulfate
  • Study type - Interventional
  • Study results - No Results Available
  • Locations -
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Single (Investigator)|Primary Purpose: Prevention
  • Enrollment - 0
  • Age - 18 Months to 85 Years   (Child, Adult, Older Adult)
  • Outcome measures - Time to reach normal body temperature|Development of COVID-19 symptoms during HCQ preventive therapy in staff|COVID-19 test result at follow-up in patients|Worsening of symptoms in COVID-19 patients
NCT04555005 Mindfulness-based Crisis Intervention for COVID-19 Frontline Healthcare Workers During COVID-19 Completed Not Applicable Mar/10/2020 Apr/26/2020
  • Alternative id - Mind-COVID-19
  • Interventions - Other: Mindfulness based intervention
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - La Paz University Hospital, Madrid, Spain
  • Study designs - Allocation: N/A|Intervention Model: Single Group Assignment|Masking: None (Open Label)|Primary Purpose: Supportive Care
  • Enrollment - 1000
  • Age - Child, Adult, Older Adult
  • Outcome measures - Perceived helpfulness to reduce current stress
NCT04367064 To Study the Clinical Characteristics and Treatment Outcome of COVID-19 Patients Admitted in Hospitals of Max Healthcare (SCOPe Study) Recruiting Apr/25/2020 Dec/25/2020
  • Alternative id - SCOPe/MHC/Covid-19/2020
  • Interventions -
  • Study type - Observational
  • Study results - No Results Available
  • Locations - Max Super Speciality hospital, Saket (A unit of Devki Devi Foundation), New Delhi, Delhi, India
  • Study designs - Observational Model: Cohort|Time Perspective: Prospective
  • Enrollment - 1000
  • Age - 18 Years to 75 Years   (Adult, Older Adult)
  • Outcome measures - we will compare the clinical outcome of the COVID 19 patients with their age and gender|we will compare the effect of different treatments given to the COVID 19 patients at Max Hospital
NCT04573361 Access to Chiropractic Care During the COVID-19 Healthcare Emergency in Spain Completed Not Applicable May/02/2020 May/27/2020
  • Alternative id - ChiroCOVID19
  • Interventions - Other: Chiropractic care (one visit)|Other: Chiropractic care (more than one visit)
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Real Centro Universitario María Cristina, San Lorenzo De El Escorial, Madrid, Spain
  • Study designs - Allocation: Non-Randomized|Intervention Model: Parallel Assignment|Masking: None (Open Label)|Primary Purpose: Treatment
  • Enrollment - 723
  • Age - 14 Years and older   (Child, Adult, Older Adult)
  • Outcome measures - Pain intensity|Pain frequency|Pain evolution|Pain interference|Pain Catastrophizing Scale|Tampa Scale Kinesiophobia|General Anxiety Disorder scale|Intolerance of Uncertainty Scale|General Self-Efficacy scale|Fear of Illness and Virus Evaluation
NCT04716088 Rapid Antigen Testing for SARS-CoV-2 Among Healthcare Workers to Prevent Spread of COVID-19 Completed Nov/18/2020 Dec/22/2020
  • Alternative id - RADT for COVID-19 Golnik
  • Interventions - Diagnostic Test: Rapid antigen test for SARS CoV2
  • Study type - Observational
  • Study results - No Results Available
  • Locations - Universitiy Clinic for respiratory and allergic diseases, Golnik, Slovenia
  • Study designs - Observational Model: Case-Only|Time Perspective: Prospective
  • Enrollment - 36
  • Age - 18 Years to 65 Years   (Adult, Older Adult)
  • Outcome measures - SARS CoV2 infection
NCT04860271 Manual Acupuncture Using Acupuncture Needle vs Press Needle for COVID-19 Healthcare Anxiety Completed Not Applicable Mar/09/2021 May/31/2021
  • Alternative id - 20-12-1513
  • Interventions - Procedure: Manual Acupuncture
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Cipto Mangunkusumo Hospital, Jakarta, Jakarta Pusat, Indonesia
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Double (Investigator, Outcomes Assessor)|Primary Purpose: Treatment
  • Enrollment - 36
  • Age - 18 Years to 60 Years   (Adult)
  • Outcome measures - Hamilton Anxiety Scale|Short-Form 36|Heart Rate Variability
NCT04345315 Correlative Study on Cancer Patients and Healthcare Professionals Exposed to Infection by Severe Acute Respiratory Syndrome-Corona Virus-2 (SARS-Cov-2), COVID-19 Causative Agent. Recruiting Mar/27/2020 Mar/01/2022
  • Alternative id - IRSTB113
  • Interventions - Other: serological test|Other: Rapid molecular test|Genetic: Next generation Sequencing (NGS) analysis|Other: serum chemistry analysis
  • Study type - Observational
  • Study results - No Results Available
  • Locations - UO Microbiologia,Centro Servizi Pievesestina, AUSL Romagna, Cesena, FC, Italy|Irst Irccs, Meldola, FC, Italy
  • Study designs - Observational Model: Cohort|Time Perspective: Other
  • Enrollment - 500
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - epidemiology|Immunoglobulin G (IgG) and Immunoglobulin M (IgM) antibodies evaluation|methods comparison|correlation between biochemical and coagulative factors with SARS-CoV-2 positivity.|phylogenetic map|interactions between the virus and host cells
NCT04922944 Post COVID-19 Vaccination Analysis in Healthcare Worker Recipients Active, not recruiting Mar/08/2021 Feb/01/2022
  • Alternative id - Pro00050032
  • Interventions - Drug: COVID-19 vaccine
  • Study type - Observational
  • Study results - No Results Available
  • Locations - Huntington Hospital, Pasadena, California, United States
  • Study designs - Observational Model: Cohort|Time Perspective: Prospective
  • Enrollment - 167
  • Age - Child, Adult, Older Adult
  • Outcome measures - Change in SARS-CoV-2 IgG Titer Over Time|Occurrence of post-vaccine reactions|Severity of post-vaccine reactions
NCT04890600 COVID-19 and Psycological Well-being in Healthcare Workers Completed Sep/01/2020 Apr/01/2021
  • Alternative id - RP 20/14
  • Interventions - Behavioral: well-being assessment
  • Study type - Observational
  • Study results - No Results Available
  • Locations - IRCCS San Raffaele Roma, Rome, Italy
  • Study designs - Observational Model: Ecologic or Community|Time Perspective: Other
  • Enrollment - 350
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Levels of anxiety and depression|Coping strategies|Levels of resilience|Levels of fear of COVID-19
NCT04492202 Knowledge, Attitudes, and Practices Towards COVID-19 Among Health Care Professionals Among Healthcare Professionals Not yet recruiting Aug/01/2020 Dec/10/2020
  • Alternative id - 00010
  • Interventions - Other: Survey
  • Study type - Observational
  • Study results - No Results Available
  • Locations -
  • Study designs - Observational Model: Other|Time Perspective: Other
  • Enrollment - 200
  • Age - 22 Years to 75 Years   (Adult, Older Adult)
  • Outcome measures - Questionnaire for the Evaluation of Knowledge, Attitude and Practise Levels of Healthcare Professionals for COVID-19|Support Approach Survey for Patients in Recovery Stage after COVID-19 Diagnosis
NCT04595175 Changes in Seroprevalence and Wellness Over Time in Healthcare Workers (CONSERVE-HCW) Recruiting Jun/10/2020 Dec/30/2021
  • Alternative id - 20-510-157-66-21
  • Interventions -
  • Study type - Observational
  • Study results - No Results Available
  • Locations - Chandler Regional Medical Center, Chandler, Arizona, United States
  • Study designs - Observational Model: Cohort|Time Perspective: Prospective
  • Enrollment - 2000
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Baseline IgG Assay Information|Change in IgG Assay Information|Compare seroprevalence of anti-SARS-CoV-2 IgG antibodies between groups|Impact of COVID-19 Pandemic on Perceived Wellness and Job Satisfaction
NCT04362124 Performance Evaluation of BCG Vaccination in Healthcare Personnel to Reduce the Severity of COVID-19 Infection. Withdrawn Phase 3 Aug/01/2020 Nov/01/2021
  • Alternative id - PEC03_2020
  • Interventions - Biological: vaccine BCG|Other: Placebo
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Program for Research and Control in Tropical Diseases - PECET, Medellín, Antioquia, Colombia
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)|Primary Purpose: Supportive Care
  • Enrollment - 0
  • Age - 18 Years to 65 Years   (Adult, Older Adult)
  • Outcome measures - Primary outcome|Secondary outcome
NCT04397848 Mental Health Outcomes in Healthcare Workers During COVID-19 Completed May/14/2020 Jul/03/2020
  • Alternative id - 3189
  • Interventions -
  • Study type - Observational
  • Study results - No Results Available
  • Locations - University Health Network, Toronto, Ontario, Canada
  • Study designs - Observational Model: Cohort|Time Perspective: Prospective
  • Enrollment - 3852
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Impact of Event Scale - Revised (IES-R)|General Anxiety Disorder (GAD-7)|Patient Health Questionnaire (PHQ-9)|Qualitative Data
NCT04922632 Data-driven Approaches to Healthcare Provider Resilience & Burnout During COVID-19 Not yet recruiting Not Applicable Jan/01/2022 Oct/01/2022
  • Alternative id - Pro00106079
  • Interventions - Behavioral: Transcendental Meditation (TM)|Behavioral: Experience Resolution Methodology (ERM)|Behavioral: Transcendental Meditation (TM) and Experience Resolution Methodology (ERM)|Behavioral: Treatment As Usual (TAU)
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Duke University Medical Center, Durham, North Carolina, United States
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: None (Open Label)|Primary Purpose: Treatment
  • Enrollment - 280
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Change in resilience as measured by the Connor-Davidson Resilience Scale-25|Change in burnout as measured by the Maslach Burnout Inventory (MBI).|Change in depression as measured by the Patient Health Questionnaire-9 (PHQ-9).|Change in psychological distress as measured by the Subject Units of Distress Scales (SUDS).|Change in quality of life as measured by the Quality of Life Enjoyment and Satisfaction Questionnaire - Short Form (Q-LES-Q-SF).|Change in PTSD symptom severity as measured by the Post-Traumatic Stress Disorder (PTSD) checklist-5 (PCL-5).|Change in sleep as measured by the Insomnia Severity Index (ISI).
NCT04333862 Assessment of Covid-19 Infection Rates in Healthcare Workers Using a Desynchronization Strategy Active, not recruiting Mar/19/2020 Jan/31/2022
  • Alternative id - 2020-00563
  • Interventions -
  • Study type - Observational
  • Study results - No Results Available
  • Locations - Guido Beldi, Bern, Switzerland
  • Study designs - Observational Model: Cohort|Time Perspective: Prospective
  • Enrollment - 500
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Fraction of healthcare workers infected with SARS-CoV-2|Fraction of healthcare workers with COVID-19|Number of patients infected in the hospital|Development of SARS-CoV2 specific antibody repertoire
NCT05236270 CATCH-UP Vaccines: Extension of Community - Engaged Approaches to Testing in Community and Healthcare Settings for Underserved Populations Not yet recruiting Not Applicable Mar/01/2022 Sep/01/2022
  • Alternative id - 13436
  • Interventions - Behavioral: multicomponent intervention to improve SARS-CoV-2 vaccination among Oklahoman's seeking SARS-CoV-2 testing at CATCH-UP testing events.
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Oklahoma Clinical and Translational Science Institute, Oklahoma City, Oklahoma, United States
  • Study designs - Allocation: Randomized|Intervention Model: Factorial Assignment|Masking: Double (Investigator, Outcomes Assessor)|Primary Purpose: Prevention
  • Enrollment - 2000
  • Age - 18 Years to 100 Years   (Adult, Older Adult)
  • Outcome measures - Intention to receive a COVID-19 vaccine post-intervention|Self-reported COVID-19 vaccine uptake
NCT04872712 Comparing Press and Filiform Needle Acupuncture Effectiveness for Improving Insomnia in COVID-19 Healthcare Workers Recruiting Not Applicable May/04/2021 Apr/07/2022
  • Alternative id - 21-02-0142
  • Interventions - Procedure: Press needles|Procedure: Filiform Needles
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Cipto Mangunkusumo Hospital, Jakarta Pusat, DKI Jakarta, Indonesia
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Double (Investigator, Outcomes Assessor)|Primary Purpose: Treatment
  • Enrollment - 34
  • Age - 20 Years to 50 Years   (Adult)
  • Outcome measures - Change in Pittsburgh Sleep Quality Index (PSQI) Questionnaire Score|Change in Melatonin Level via Blood Test
NCT04353128 Efficacy of Melatonin in the Prophylaxis of Coronavirus Disease 2019 (COVID-19) Among Healthcare Workers. Completed Phase 2|Phase 3 Apr/20/2020 Dec/01/2020
  • Alternative id - MeCOVID
  • Interventions - Drug: Melatonin 2mg|Drug: Placebo oral tablet
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Hospital Universitario La Paz, Madrid, Spain
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)|Primary Purpose: Prevention
  • Enrollment - 450
  • Age - 18 Years to 65 Years   (Adult, Older Adult)
  • Outcome measures - SARS-CoV 2 infection rate
NCT04386759 COVID-19 Infection in Healthcare Workers Completed May/18/2020 Jul/26/2021
  • Alternative id - APHP200483
  • Interventions - Other: Cohort
  • Study type - Observational
  • Study results - No Results Available
  • Locations - Assistance Publique Hôpitaux de Paris - CHU Henri Mondor, Créteil, France
  • Study designs - Observational Model: Cohort|Time Perspective: Other
  • Enrollment - 1858
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - SARS-COV-2 infection|SARS-COV-2 incidence regarding hospitals, assigned services and profession|Individual and contextual risks factors
NCT04843917 Immunity Against COVID-19 Vaccine in Healthcare Workers in Argentine Recruiting Apr/09/2021 Aug/09/2022
  • Alternative id - 3913
  • Interventions - Diagnostic Test: Immunoglobulin G detection
  • Study type - Observational
  • Study results - No Results Available
  • Locations - Hospital Italiano de Buenos Aires, Buenos Aires, Caba, Argentina
  • Study designs - Observational Model: Cohort|Time Perspective: Prospective
  • Enrollment - 100
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - To assess the change in the levels of Immunoglobulin G (IgG) antibodies from baseline at 1 month, at 6 months and at 12 months after the completion of the immunization in health workers who received a COVID-19 vaccine|To correlate the Immunoglobulin G levels with the presence of adverse events and infection with COVID-19
NCT04410016 Evaluation of Staff COVID-19 Wellbeing Centres in a Healthcare Workplace: COVID-WELL Study Completed Not Applicable May/25/2020 Oct/30/2020
  • Alternative id - COVID-WELL_May20
  • Interventions - Other: Staff Wellbeing Centres
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Nottingham University Hospitals NHS Trust, Nottingham, Nottinghamshire, United Kingdom
  • Study designs - Allocation: N/A|Intervention Model: Single Group Assignment|Masking: None (Open Label)|Primary Purpose: Other
  • Enrollment - 819
  • Age - Child, Adult, Older Adult
  • Outcome measures - Warwick-Edinburgh Mental Wellbeing Scale|Single Item Measure of Global Job Stressfulness (Houdmont et al, 2019)|Single Item Global Job Satisfaction Measure (Dolbier et al, 2005)|Single Item Measure of Presenteeism (Aronsson & Gustafsson, 2004)|Single Item Measure of Turnover intentions (Ryan et al, 2017)|Work Engagement (Shaufeli et al, 2006)
NCT04283838 Humanistic Care in Healthcare Workers in Coronavirus Disease 2019 Withdrawn Not Applicable Feb/22/2020 May/15/2020
  • Alternative id - XJTU2H-WH2
  • Interventions - Behavioral: Humanistic Care
  • Study type - Interventional
  • Study results - No Results Available
  • Locations -
  • Study designs - Allocation: N/A|Intervention Model: Single Group Assignment|Masking: None (Open Label)|Primary Purpose: Prevention
  • Enrollment - 0
  • Age - Child, Adult, Older Adult
  • Outcome measures - Self-rating depression scale|Incidence of PTSD
NCT04334928 Randomized Clinical Trial for the Prevention of SARS-CoV-2 Infection (COVID-19) in Healthcare Personnel Completed Phase 3 Apr/15/2020 Jul/11/2021
  • Alternative id - PrEP COVID-19
  • Interventions - Drug: Emtricitabine/tenofovir disoproxil|Drug: Hydroxychloroquine|Drug: Placebo: Emtricitabine/tenofovir disoproxil Placebo|Drug: Placebo: Hydroxychloroquine
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Hospital Universitario de Ferrol, Ferrol, A Coruña, Spain|Hospital Clínico Universitario de Santiago, Santiago De Compostela, A Coruña, Spain|Hospital General de Elche, Elche, Alicante, Spain|Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain|Hospital Sant Joan de Deu de Esplugues, Esplugues De Llobregat, Barcelona, Spain|Parc Sanitari Sant Joan de Déu de Sant Boi, Sant Boi De Llobregat, Barcelona, Spain|Hospital Moisès Broggi, Sant Joan Despí, Barcelona, Spain|Hospital Infanta Margarita, Cabra, Córdoba, Spain|Hospital Insular de Las Palmas, Las Palmas De Gran Canaria, Gran Canaria, Spain|Hospital Universitario de Canarias, Las Palmas De Gran Canaria, Gran Canaria, Spain|Hospital de Donostia, San Sebastián, Guipuzcoa, Spain|Hospital San Pedro, Logroño, La Rioja, Spain|Hospital Principe de Asturias, Alcalá De Henares, Madrid, Spain|Hospital Fundación de Alcorcón, Alcorcón, Madrid, Spain|Hospital Colllado Villalba, Collado-Villalba, Madrid, Spain|Hospital de Getafe, Getafe, Madrid, Spain|Hospital Severo Ochoa, Leganés, Madrid, Spain|Hospital de Móstoles, Móstoles, Madrid, Spain|Hospital Rey Juan Carlos, Móstoles, Madrid, Spain|Hospital Quirón Pozuelo, Pozuelo De Alarcón, Madrid, Spain|Hospital de Torrejón, Torrejón De Ardoz, Madrid, Spain|Hospital Infanta Elena, Valdemoro, Madrid, Spain|Hospital Virgen del Castillo, Yecla, Murcia, Spain|Hospital Costa del Sol, Marbella, Málaga, Spain|Complejo Hospitalario de Navarra, Pamplona, Navarra, Spain|Hospital Reina Sofía, Tudela, Navarra, Spain|Hospital Arnau de Vilanova, Llíria, Valencia, Spain|Hospital de Araba, Alava, Vitoria, Spain|Hospital General Universitario de Albacete, Albacete, Spain|Centro Médico Teknon, Barcelona, Spain|Hospital Clinic, Barcelona, Spain|Hospital del Mar, Barcelona, Spain|Hospital Dexeus, Barcelona, Spain|Hospital Quirón Barcelona, Barcelona, Spain|Hospital Universitario Sagrat Cor, Barcelona, Spain|Hospital Universitario de Burgos, Burgos, Spain|Hospital Virgen de la Luz, Cuenca, Spain|Hospital Clínico San Cecilio, Granada, Spain|Hospital Universitario de León, León, Spain|Hospital Universitario Ramón y Cajal, Madrid, Spain|Fundación Jiménez Díaz, Madrid, Spain|Hospital Clinico San Carlos, Madrid, Spain|Hospital Infanta Leonor, Madrid, Spain|Hospital La Princesa, Madrid, Spain|Hospital Universitario 12 de Octubre, Madrid, Spain|Hospital Universitario Gregorio Marañon, Madrid, Spain|Hospital Universitario La Paz, Madrid, Spain|Hospital Universitario Puerta de Hierro, Madrid, Spain|Hospital Reina Sofía, Murcia, Spain|Hospital Universitario Virgen de la Arrixaca, Murcia, Spain|Hospital Virgen de la Victoria, Málaga, Spain|Complejo Asistencial de Palencia, Palencia, Spain|Hospital Universitario de Salamanca, Salamanca, Spain|Hospital General de Segovia, Segovia, Spain|Hospital Virgen del Rocio, Sevilla, Spain|Hospital Virgen Macarena, Sevilla, Spain|Hospital Clinico Universitario, Valencia, Spain|Hospital Dr. Peset, Valencia, Spain|Hospital General de Valencia, Valencia, Spain|Hospital La Fe, Valencia, Spain|Hospital de Valladolid, Valladolid, Spain|Hospital Rio Hortega, Valladolid, Spain|Hospital Lozano Blesa, Zaragoza, Spain|Hospital Miguel Servet, Zaragoza, Spain|Hospital Nuestra Señora de Sonsoles, Ávila, Spain
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Double (Participant, Investigator)|Primary Purpose: Prevention
  • Enrollment - 1002
  • Age - 18 Years to 70 Years   (Adult, Older Adult)
  • Outcome measures - Number of confirmed symptomatic infections of SARS-CoV-2 (COVID-19)|Severity of disease in confirmed infected participants of SARS-CoV-2 (COVID-19)|Duration of symptoms in confirmed infected participants of SARS-CoV-2 (COVID-19) measured in days
NCT04370119 Screening for COVID-19 and Monitoring of Serological Responses to SARS-CoV-2 in Healthcare Workers Active, not recruiting Apr/27/2020 May/01/2025
  • Alternative id - BB 068/20
  • Interventions - Diagnostic Test: Nasal swab|Diagnostic Test: Serum testing
  • Study type - Observational
  • Study results - No Results Available
  • Locations - Greifswald University Medicine, Greifswald, Germany
  • Study designs - Observational Model: Cohort|Time Perspective: Prospective
  • Enrollment - 1092
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Number of people with detectable antibodies to SARS-CoV-2|Number of people with detectable SARS-CoV-2 nucleic acid
NCT04506515 Psychological Impact of COVID-19 Pandemic in Healthcare Workers Completed Apr/09/2020 Apr/30/2020
  • Alternative id - COV2-2020
  • Interventions - Diagnostic Test: Psychological stress and adaptation at work score (PSAS)
  • Study type - Observational
  • Study results - No Results Available
  • Locations - CHGUV, Valencia, Spain
  • Study designs - Observational Model: Ecologic or Community|Time Perspective: Cross-Sectional
  • Enrollment - 3000
  • Age - 18 Years to 70 Years   (Adult, Older Adult)
  • Outcome measures - PSAS (Psychological Stress and Adaptation at work Score) during the crisis|PSAS (Psychological Stress and Adaptation at work Score) in basal conditions
NCT04927936 A Trial Among HealthCare Workers (HCW) Vaccinated With Janssen Vaccine: the SWITCH Trial Recruiting Not Applicable Jun/25/2021 Sep/01/2022
  • Alternative id - MEC-2021-0132|2021-000701-24
  • Interventions - Biological: Vaccination once with Janssen vaccine (only priming)|Biological: Vaccination with Janssen vaccine followed with Janssen vaccine (homologous boosting).|Biological: Vaccination with Janssen vaccine followed with Moderna vaccine (heterologous boosting).|Biological: Vaccination with Janssen vaccine followed with Pfizer vaccine (heterologous boosting).
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - AmsterdamUMC, Amsterdam, Netherlands|UMCG, Groningen, Netherlands|LUMC, Leiden, Netherlands|Erasmus MC, Rotterdam, Netherlands
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Single (Participant)|Primary Purpose: Prevention
  • Enrollment - 432
  • Age - 18 Years to 65 Years   (Adult, Older Adult)
  • Outcome measures - Determination of antibodies by a quantitative IgG assay (LIAISON SARS-CoV-2 TrimericS IgG essay) 28 days after booster
NCT04735744 Evaluation of Allied Healthcare in Patients Recovering From COVID-19 Active, not recruiting Mar/29/2021 Jan/01/2024
  • Alternative id - ParaCOV
  • Interventions - Other: Patients recovering from COVID19 receive usual care by allied health professionals
  • Study type - Observational
  • Study results - No Results Available
  • Locations - Radboud University Medical Center, Nijmegen, Gelderland, Netherlands
  • Study designs - Observational Model: Cohort|Time Perspective: Prospective
  • Enrollment - 1451
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Participation|Quality of life measured with EQ-5D-5L|Fatigue|Physical functioning|Costs|Patient Specific Activities|Nutritional Status|Global Assessment|Voice Problems|Swallowing Problems|Activities|Exercise capacity|Quadriceps strength|Hand grip strength|Bioimpedance (BIA|VAS-appetite, taste and smell|Dietary goal attainment|Liquid medical nutrition|Sarcopenia|Types of Stool|Physical Functioning|Cognitive Functioning
NCT04351568 Professional and Ethical Challenges of Social Media Usage in Providing Healthcare Services During the Period of 19 Covid Pandemics; Recruiting Apr/01/2020 Aug/01/2020
  • Alternative id - 2020A20
  • Interventions - Other: quesionnair
  • Study type - Observational
  • Study results - No Results Available
  • Locations - Assiut, Assiut, Egypt
  • Study designs - Observational Model: Ecologic or Community|Time Perspective: Cross-Sectional
  • Enrollment - 874
  • Age - 18 Years to 60 Years   (Adult)
  • Outcome measures - to evaluate the effect of social media usage in medical practice during covid 19 epidemic
NCT04631497 Assessment of Stress, Depression and Anxiety in Healthcare Caring for Patients With COVID-19 Recruiting Jul/01/2020 Dec/31/2021
  • Alternative id - 1072.6120.161.2020
  • Interventions - Diagnostic Test: test
  • Study type - Observational
  • Study results - No Results Available
  • Locations - University Hospital in Cracow, Kraków, Poland
  • Study designs - Observational Model: Cohort|Time Perspective: Prospective
  • Enrollment - 100
  • Age - 18 Years to 70 Years   (Adult, Older Adult)
  • Outcome measures - Depression|Stress|Deal with Stress|Stress 2
NCT04372056 The COVID-ICU Healthcare Professional Study Completed May/06/2020 Jun/04/2021
  • Alternative id - 136144
  • Interventions - Behavioral: Views and experiences of health care professionals working in intensive care units during the COVID-19 pandemic
  • Study type - Observational
  • Study results - No Results Available
  • Locations - Oslo university hospital, Oslo, Norway
  • Study designs - Observational Model: Cohort|Time Perspective: Prospective
  • Enrollment - 484
  • Age - 20 Years and older   (Adult, Older Adult)
  • Outcome measures - Views and experiences of health care professionals working in intensive care units during the COVID-19 pandemic
NCT04318314 COVID-19: Healthcare Worker Bioresource: Immune Protection and Pathogenesis in SARS-CoV-2 Recruiting Mar/18/2020 Apr/30/2022
  • Alternative id - 130852
  • Interventions - Diagnostic Test: COPAN swabbing and blood sample collection
  • Study type - Observational
  • Study results - No Results Available
  • Locations - Barts Heart Center, London, United Kingdom|Royal Free London NHS Foundation Trust, London, United Kingdom
  • Study designs - Observational Model: Cohort|Time Perspective: Prospective
  • Enrollment - 731
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Seroconversion to SARS-CoV-2 positivity
NCT04328285 Chemoprophylaxis of SARS-CoV-2 Infection (COVID-19) in Exposed Healthcare Workers Active, not recruiting Phase 3 Apr/14/2020 Mar/30/2022
  • Alternative id - 20PH061|2020-001188-96
  • Interventions - Drug: Hydroxychloroquine|Drug: Placebo of Hydroxychloroquine|Drug: Lopinavir and ritonavir|Drug: Placebo of LPV/r Tablets
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - CHU d'Angers, Angers, France|CHU de Bordeaux, Bordeaux, France|CHU de Clermont-Ferrand, Clermont-ferrand, France|CHU de Montpellier, Montpellier, France|CHU de Nancy, Nancy, France|CHU de Nantes, Nantes, France|CHU de Rennes, Rennes, France|CHU de Rouen, Rouen, France|CHU de Saint-Etienne, Saint-Étienne, France
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Triple (Participant, Investigator, Outcomes Assessor)|Primary Purpose: Prevention
  • Enrollment - 1200
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Occurrence of an symptomatic or asymptomatic SARS-CoV-2 infection among healthcare workers (HCWs)|Evaluation of the occurrence of adverse events in each arm,|Evaluation of the discontinuation rates of the investigational drug in each arm,|Evaluation of the adherence of participants to study drug,|Evaluation of the incidence of symptomatic cases of SARS-CoV-2 infection in each arm,|Evaluation of the incidence of asymptomatic cases of SARS-CoV-2 infection in each arm|Evaluation of the incidence of severe cases of SARS-CoV-2 infection in each arm.|corrected QT interval (ms)
NCT04729075 Associations Between COVID-19 ARDS Treatment, Clinical Trajectories and Liberation From Mechanical Ventilator - an Analysis of the NorthCARDS Dataset Completed Jan/19/2021 Jan/19/2021
  • Alternative id - 19-0598
  • Interventions - Other: ARDS and COVID19 treatments
  • Study type - Observational
  • Study results - No Results Available
  • Locations - Feinstein Institutes for Medical Research, Manhasset, New York, United States
  • Study designs - Observational Model: Cohort|Time Perspective: Other
  • Enrollment - 1800
  • Age - Child, Adult, Older Adult
  • Outcome measures - Index Hospital Survival|Time to Mechanical Ventilator Liberation|Hospital Readmission
NCT04312243 NO Prevention of COVID-19 for Healthcare Providers Active, not recruiting Phase 2 Apr/07/2020 Apr/07/2022
  • Alternative id - NOpreCOVID-19
  • Interventions - Drug: Inhaled nitric oxide gas
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Massachusetts General Hospital, Boston, Massachusetts, United States
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: None (Open Label)|Primary Purpose: Prevention
  • Enrollment - 24
  • Age - 18 Years to 99 Years   (Adult, Older Adult)
  • Outcome measures - COVID-19 diagnosis|Positive SARS-CoV-2 rt-PCR test
NCT04460196 Healthcare Renunciation During the Confinement Period in Connection With the COVID-19 Epidemic in Adult Emergency Departments Completed Jul/08/2020 Sep/18/2020
  • Alternative id - 49RC20_0155
  • Interventions - Other: survey
  • Study type - Observational
  • Study results - No Results Available
  • Locations - CHU Angers, Angers, France|CH Le Mans, Le Mans, France
  • Study designs - Observational Model: Cohort|Time Perspective: Prospective
  • Enrollment - 900
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - rate of patients who gave up consulting in the emergency department
NCT04379336 BCG Vaccination for Healthcare Workers in COVID-19 Pandemic Completed Phase 3 May/04/2020 Jan/02/2022
  • Alternative id - TASK-008 BCG-CORONA
  • Interventions - Biological: Bacille Calmette-Guérin (BCG)|Other: Placebo Comparator
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - TASK Foundation, Cape Town, Western Cape, South Africa
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)|Primary Purpose: Prevention
  • Enrollment - 1000
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Incidence of HCWs hospitalized due to COVID-19 per arm|Incidence of SARS-CoV-2 infection per arm|Incidence of upper respiratory tract infections per arm|Days of unplanned absenteeism due to COVID-19 or any reason per arm|Incidence of hospitalization for any reason per arm|Incidence of intensive care unit admission per arm|Incidence of death per arm|Prevalence of latent TB infection|Incidence of active TB per arm|Compare the effect of latent TB on morbidity and mortality due to COVID-19 per arm|Incidence of treatment related adverse events
NCT04354792 Asymptomatic COVID-19 Infection Among Healthcare Workers Completed May/01/2020 Jun/10/2020
  • Alternative id - N-31-2020
  • Interventions - Diagnostic Test: Serum SARs COV 2 IGg screening in health care workers
  • Study type - Observational
  • Study results - No Results Available
  • Locations - Cairo University Hospital, Cairo, Egypt
  • Study designs - Observational Model: Cohort|Time Perspective: Cross-Sectional
  • Enrollment - 500
  • Age - 25 Years to 60 Years   (Adult)
  • Outcome measures - Number of IGg seropositive health care workers|Differentiation between low risk and high risk HCWs
NCT04334876 Rapid SARS-CoV-2 IgG Antibody Testing in High Risk Healthcare Workers Completed Not Applicable Apr/01/2020 Jan/01/2021
  • Alternative id - 2003973826
  • Interventions - Diagnostic Test: SARS-CoV-2 IgG Antibody Testing Kit
  • Study type - Interventional
  • Study results - Has Results
  • Locations - Indiana University Health Hospital, Indianapolis, Indiana, United States
  • Study designs - Allocation: N/A|Intervention Model: Single Group Assignment|Masking: None (Open Label)|Primary Purpose: Diagnostic
  • Enrollment - 571
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Number of Participant Health Care Workers With a Positive Rapid, At-home, Point-of-care (POC) SARS-CoV2 IgG Antibody Test.|Number of Healthcare Workers Willing to be Convalescent Plasma Donors if Appropriate
NCT04846790 The Effect of a Combined Nature-based and Virtual Mindfulness Intervention on Perceived Stress in Healthcare Workers Enrolling by invitation Not Applicable Jul/16/2021 Jun/01/2023
  • Alternative id - CC-000192
  • Interventions - Behavioral: Nature Only|Behavioral: Nature+Mindfulness
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - National Institutes of Health, Clinical Center, Bethesda, Maryland, United States
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)|Primary Purpose: Supportive Care
  • Enrollment - 90
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Perceived Stress Scale (PSS)|Insomnia Severity Index (ISI)|Maslach Burnout Inventory (MBI 2-Item)|Posttraumatic Stress Disorder Checklist for DSM-5 (PCL-5)|Hospital Anxiety and Depression Scale (HADS)|Mindful Attention Awareness Scale-State Version (MAAS-S)|General Self-Efficacy Scale (GSF)|National Institutes of Health-Healing Experience of All Life Stressors (NIH-HEALS)
NCT05000268 Examination of The Effects of Telerehabilitation in Painful Healthcare Workers With and Without COVID-19 Infection Not yet recruiting Not Applicable Jan/16/2022 Apr/30/2022
  • Alternative id - AIBU-FTR-CT-04
  • Interventions - Other: Progressive Myofascial Relaxation Exercise
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Bolu Abant İzzet Baysal Üniversitesi İzzet Baysal Ruh Sağlığı ve Hastalıkları Eğitim ve Araştırma Hastanesi, Bolu, Turkey|Düzce Atatürk Devlet Hastanesi, Bolu, Turkey
  • Study designs - Allocation: Non-Randomized|Intervention Model: Single Group Assignment|Masking: None (Open Label)|Primary Purpose: Treatment
  • Enrollment - 58
  • Age - 15 Years to 75 Years   (Child, Adult, Older Adult)
  • Outcome measures - Visual Analog Scale|Pittsburgh Sleep Quality Index|Fatigue Severity Scale|Tampa Scale of Kinesiophobia|The Patient Health Questionnaire-4|Modified Borg Dyspnoea Scale|Modified Medical Research Council Dyspnea Scale|Hospital Anxiety and Depression Scale
NCT05167227 Does a Technology Enabled Multi-disciplinary Team-based Care Model for the Management of Long COVID and Other Fatiguing Illnesses Improve Clinical Care of Patients and Represent a Sustainable Approach Within a Federally Qualified Health Center? Recruiting Not Applicable Nov/30/2021 Jul/31/2024
  • Alternative id - HS-2021-0241
  • Interventions - Other: Extension for Community Healthcare Outcomes
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Family Health Centers of San Diego, San Diego, California, United States
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Double (Investigator, Outcomes Assessor)|Primary Purpose: Treatment
  • Enrollment - 20
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Patient-Reported Outcomes Measurement Information System (PROMIS)-29|Patient symptom checklist with associated severity for those present|If symptom is present, has patient experienced this in the past month|If symptom is present, how long has patient experienced this symptom|If symptom is present, did patient have this symptom before you tested positive for COVID-19?|If symptom is present, during the past month how often have you had this symptom?|If symptom is present during the past month, how bad was this symptom?|For symptoms present, do any of them get worse for at least 24 hours after engaging in activities (physical or mental) that patient was used to doing with no problems?|If fatigue, tiredness, or exhaustion is present, doesn't patient describe it as feeling it come on all of a sudden, or slowly over time|If fatigue present, what month and year did the fatiguing illness begin?|When fatigued, does rest make patient's fatigue better?|When fatigued, has this fatigue substantially limited the patient's ability to occupational, educational, social, or personal activities?|Patient's medical history check-list|Patient's dietary restrictions|Patient's food allergies or other food intolerances|Has patient's employment been impacted due to contracting COVID-19?|Patient's frequency to complete 150-minutes per week of moderate-intensity physical activity (like a brisk walk, slow biking, gardening, or ballroom dancing) prior to contracting COVID-19|Patient's frequency to complete 150-minutes per week of vigorous-intensity physical activity (like running, swimming laps, competitive sports, or fast bicycling) prior to contracting COVID-19|Did patient receive a COVID-19 PCR (nasal swab) test|Did patient receive a COVID-19 antibody test|Patient symptom onset|Patient reported medications used for COVID-19 symptoms|Patient reported prescribed supplementary oxygen support|Patient reported admittance to hospital due to COVID-19|Do any of the following activities exacerbate patients symptoms: Physical exertion, Diet Changes, Big Meal, Dehydration, Weather changes (hot and humid), Tight clothing, Stress or anxiety, Pre Menstrual period, Menstrual period, Alcohol consumption|Does patient feel fully recovered from COVID-19|Currently minutes per week of moderate-intensity physical activity patient does (like a brisk walk, slow biking, gardening, or ballroom dancing)|Currently minutes per week of vigorous-intensity physical activity patient does (like running, swimming laps, competitive sports, or fast bicycling)|Patient Health Questionnaire (PHQ)-2|Patient Health Questionnaire (PHQ)-9 (if applicable)|PROMIS Dyspnea Functional Limitations and Severity Short Forms|PROMIS Applied Cognition Abilities and General Concerns Short Forms|Generalized Anxiety Disorder (GAD)-7|2-minute step test|30 sec sit to stand test|Grip strength|Functional Gait Assessment|Balance tasks|Post-exertional malaise follow-up
NCT04948216 Management and Healthcare Utilization of Patients With Chronic Airway Disease During the COVID-19 Epidemic Completed Apr/28/2020 May/13/2020
  • Alternative id - LM2020133
  • Interventions - Other: No intervention
  • Study type - Observational
  • Study results - No Results Available
  • Locations - Peking University Third Hospital, Beijing, Beijing, China
  • Study designs - Observational Model: Other|Time Perspective: Cross-Sectional
  • Enrollment - 153
  • Age - 40 Years and older   (Adult, Older Adult)
  • Outcome measures - Respiratory symptoms|Frequency of exacerbation during the COVID-19 epidemic
NCT04409574 COVID 19 Viral Clearance Among the Infected Healthcare Workers In Assiut University Hospitals Not yet recruiting Jun/01/2020 Jun/01/2021
  • Alternative id - COVID19 among HCWs
  • Interventions -
  • Study type - Observational
  • Study results - No Results Available
  • Locations -
  • Study designs - Observational Model: Case-Only|Time Perspective: Cross-Sectional
  • Enrollment - 31
  • Age - 18 Years to 50 Years   (Adult)
  • Outcome measures - the time of Covid 19 viral clearance in medical healthcare workers and its relation to clinical presentation, severity among and resolution of symptoms.|knowledge and practice of infection control measures
NCT04456595 Clinical Trial of Efficacy and Safety of Sinovac's Adsorbed COVID-19 (Inactivated) Vaccine in Healthcare Professionals Active, not recruiting Phase 3 Jul/21/2020 Feb/01/2022
  • Alternative id - COV-02-IB
  • Interventions - Biological: Adsorbed COVID-19 (inactivated) Vaccine|Biological: Placebo
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Universidade de Brasília, Brasilia, DF, Brazil|Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil|Hospital Universitário Júlio Müller, Cuiabá, Mount, Brazil|Hospital Universitário Maria Aparecida Pedrossian, Campo Grande, MS, Brazil|Hospital das Clínicas da Universidade Federal do Paraná, Curitiba, PR, Brazil|Hospital Escola da Universidade Federal de Pelotas, Pelotas, RS, Brazil|Hospital São Lucas da Pontificia Universidade Catolica do Rio Grande do Sul, Porto Alegre, RS, Brazil|Hospital de Amor - Fundação Pio XII, Barretos, SP, Brazil|Hospital das Clínicas da UNICAMP, Campinas, SP, Brazil|Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo, Ribeirao Preto, SP, Brazil|Instituto de Infectologia Emílio Ribas, Sao Paulo, SP, Brazil|Centro de Pesquisas Clínicas do Instituto Central do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, SP, Brazil|Instituto Israelita de Ensino e Pesquisa Albert Einstein, Sao Paulo, SP, Brazil|Universidade Municipal de São Caetano do Sul, São Caetano do Sul, SP, Brazil|Faculdade de Medicina de São José do Rio Preto - FAMERP, São José Do Rio Preto, São Paulo, Brazil|Instituto de Infectologia Evandro Chagas - Fiocruz, Rio De Janeiro, Brazil
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)|Primary Purpose: Prevention
  • Enrollment - 12688
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Incidence of COVID-19 cases after two-doses immunization schedule|Frequency of adverse events up to seven days after immunization|Incidence of COVID-19 cases after two-doses immunization schedule according to previous exposure|Incidence of COVID-19 cases after 14-days of first immunization|Combined incidence of SARS-CoV-2 infection|Incidence of severe COVID-19 cases after two-doses immunization schedule|Frequency of adverse events up to 28 days after immunization|Frequency of severe COVID-19 cases|Frequency of adverse events of special interest after immunization|Seroconversion rate|Cell-mediated immune profile|Seropositivity rate
NCT04720404 Mindful Prevention of Psychopathology in Healthcare Workers During the COVID-19 Crisis (COVID-19 MindPreP) Recruiting Not Applicable Jun/23/2020 Feb/01/2022
  • Alternative id - MFN-COVID-19 2020-22
  • Interventions - Behavioral: Mindfulness-Based Stress Reduction|Other: Self-help mindfulness/compassion exercises|Other: Support as usual
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Radboud university medical center, Nijmegen, Netherlands
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Single (Outcomes Assessor)|Primary Purpose: Prevention
  • Enrollment - 220
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Somatoform symptoms, Anxiety, Depression|Occurence of psychopathology|Post-traumatic stress symptoms|Severity of insomnia|Alcohol use|Posttraumatic growth|Positive mental health|Health-related quality of life|Costs
NCT04469647 COVID 19 Seroprevalence Amongst Healthcare Workers in JHAH Enrolling by invitation Jul/19/2020 Jun/15/2021
  • Alternative id - IRB20-09
  • Interventions - Diagnostic Test: Serology Test
  • Study type - Observational
  • Study results - No Results Available
  • Locations - Johns Hopkins Aramco Healthcare, Dhahran, Eastern, Saudi Arabia
  • Study designs - Observational Model: Cohort|Time Perspective: Cross-Sectional
  • Enrollment - 1200
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Seroconversion status|The proportion of asymptomatic infections among staff who have seroconverted|The durability of COVID 19 seroconversion in asymptomatic healthcare workers at JHAH|Identification of risk factors for COVID 19 seroconversion in asymptomatic healthcare workers
NCT04615949 Cannabidiol in Patients With COVID-19 and Cardiovascular Disease or Risk Factors Recruiting Phase 2|Phase 3 Apr/30/2021 Apr/01/2022
  • Alternative id - CARDIOL 100-03
  • Interventions - Drug: Cannabidiol, pharmaceutically produced with < 5 ppm THC|Drug: Placebo
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Valleywise Health Medical Center, Phoenix, Arizona, United States|Westchester General Hospital, Miami, Florida, United States|University of South Florida, Tampa, Florida, United States|Prairie Education and Research Cooperative, Springfield, Illinois, United States|Lutheran Health Physicians, Fort Wayne, Indiana, United States|Lowcountry Infectious Disease, Charleston, South Carolina, United States|PRX Research/Dallas Regional Medical Center, Mesquite, Texas, United States|University of Texas Health Science Center, San Antonio, Texas, United States|Baylor Scott & White Health - Temple, Temple, Texas, United States|Liga de Hipertensão arterial, Goiânia, Goiás, Brazil|Sociedade Hospitalar Angelina Caron, Campina Grande Do Sul, Parana, Brazil|Science Valley Research Institute, Campo Largo, Parana, Brazil|Universidade Estadual de Maringa, Maringa, Parana, Brazil|Hospital de Clinicas de Porto Alegre, Porto Alegre, Rio Grande Do Sul, Brazil|Instituto de Cardiologia do Rio Grande do Sul, Porto Alegre, Rio Grande Do Sul, Brazil|Hospital São Lucas PUCRS, Porto Alegre, Rio Grande Do Sul, Brazil|Irmandade Santa Casa de Misericórdia, Porto Alegre, Rio Grande Do Sul, Brazil|Núcleo de Ensino e Pesquisa do Instituto Mário Penna, Conjunto ACM, Santa Maria, Brazil|Fundação Pio XII - Hospital de Amor Barretos, Barretos, Sao Paulo, Brazil|Science Valley Research Institute- Hospital Municipal de Barueri Dr. Francisco Moran, Barueri, Sao Paulo, Brazil|IPECC-Instituto de Pesquisa Clínica de Campinas, Campinas, Sao Paulo, Brazil|Instituto do Coração do HCFMUSP, Cerqueira César, Sao Paulo, Brazil|SVRI- Irmandade de Santa Casa de Misercordia de Santos, Jabaquara, Sao Paulo, Brazil|Science Valley Research Institute, Morumbi, Sao Paulo, Brazil|Science Valley Research Institute, Santo André, Sao Paulo, Brazil|Fundação Faculdade Regional de Medicine de Sao Jose do Rio Preto (SJRP), São José Do Rio Preto, Sao Paulo, Brazil|IAMSPE - Instituto de Assitencia Medica do Servidor Público Estadual, São Paulo, Sao Paulo, Brazil|Hospital 9 de Julho, São Paulo, Sao Paulo, Brazil|Hucff- Ufrj, Rio De Janeiro, Brazil|Complexo Hospitalar de Niteroi- Centro de Pesquisa Clinica, Rio de Janeiro, Brazil|Charite Universitatsmedizin Berlin, Berlin, Germany|Medical School of Bradenburg Theodor Fontane (MHB), Neuruppin, Germany|TecSalud, Monterrey, Nuevo Leon, Mexico|Unidad Medica para la Salud Integral UMSI, San Nicolás De Los Garza, Nuevo Leon, Mexico|Centro para el Desarrollo de la Medicina Y de la Asistencia Medica Especializada, Culiacan, Sinaloa, Mexico
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)|Primary Purpose: Prevention
  • Enrollment - 422
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - All-cause mortality|Requirement for ICU admission and/or ventilatory support|CV complications
NCT05036941 A Trial of Two Mask Systems in Preventing SARS CoV-2 in Healthcare Workers (HCW) Recruiting Not Applicable Nov/13/2021 Feb/01/2022
  • Alternative id - APM/AM/001
  • Interventions - Device: Acteev™ Masks|Device: Comparison Masks
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Jehangir Clinical Development Centre (JCDC) Pvt. Ltd, Pune, Maharashtra, India
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: None (Open Label)|Primary Purpose: Prevention
  • Enrollment - 1600
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - The efficacy of Acteev™ system vs standard system in preventing SARS CoV-2 infection in health care workers|The efficacy of Acteev™ system vs standard system in preventing CRI/ILI infection in healthcare workers
NCT05102656 Patient Perceptions of the Relational Empathy of Healthcare Practitioners From the Department of Emergency Medicine During the COVID-19 Pandemic Recruiting Jun/02/2021 Dec/31/2022
  • Alternative id - 2020-1298|NCI-2021-10960
  • Interventions - Other: Best Practice|Procedure: Discussion|Other: Questionnaire Administration
  • Study type - Observational
  • Study results - No Results Available
  • Locations - M D Anderson Cancer Center, Houston, Texas, United States
  • Study designs - Observational Model: Cohort|Time Perspective: Prospective
  • Enrollment - 106
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Patients' perceptions of healthcare provider empathy
NCT04366180 Evaluation of the Probiotic Lactobacillus Coryniformis K8 on COVID-19 Prevention in Healthcare Workers Recruiting Not Applicable Apr/24/2020 Oct/01/2020
  • Alternative id - P054
  • Interventions - Dietary Supplement: Probiotic|Dietary Supplement: Control
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Raquel Rodriguez Blanque, Granada, Spain
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)|Primary Purpose: Prevention
  • Enrollment - 314
  • Age - 20 Years and older   (Adult, Older Adult)
  • Outcome measures - Incidence of SARS CoV-2 infection in healthcare workers|Incidence of hospital admissions caused by SARS-CoV-2 infection|Incidence of ICU admissions caused by SARS-CoV-2 infection|Incidence of pneumonia caused by SARS-CoV-2 infection|Incidence of oxygen support requirement caused by SARS-CoV-2 infection|Incidence of gastrointestinal symptoms caused by SARS-CoV-2 infection|Days with body's temperature > 37.5 ºC|Days with cough|Days with fatigue|Medical treatment
NCT04320056 Closed-Loop Oxygen to Verify That Healthcare Workers Interventions Decrease During SARS-CoV-2 Pneumonia (COVID-19) Recruiting Not Applicable Apr/20/2020 Oct/31/2021
  • Alternative id - 21909
  • Interventions - Other: Standard administration of oxygen flow|Device: Automated oxygen administration - FreeO2
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval, Quebec, Canada
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: None (Open Label)|Primary Purpose: Other
  • Enrollment - 216
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - The number of interventions|Duration of interventions|Mean oxygen flow|Time within theSpO2 target|Time with hypoxemia|Time with hyperoxemia|Rate of ICU admission|Rate of needed non invasive respiratory support|Rate of intubation|NEWS 2 score evolution|EWSO2 score evolution|Cost-effectiveness|length of stay
NCT04680819 Evaluation of the Effect of Anatolian Propolis on Covid-19 in Healthcare Professionals Not yet recruiting Dec/25/2020 Jan/25/2021
  • Alternative id - AtaturkU2
  • Interventions - Dietary Supplement: Anatolian Propolis
  • Study type - Observational
  • Study results - No Results Available
  • Locations -
  • Study designs - Observational Model: Cohort|Time Perspective: Prospective
  • Enrollment - 50
  • Age - 18 Years to 65 Years   (Adult, Older Adult)
  • Outcome measures - Covid-19 positive
NCT04340349 Low-dose Hydroxychloroquine and Bromhexine: a Novel Regimen for COVID-19 Prophylaxis in Healthcare Professionals Enrolling by invitation Early Phase 1 Feb/01/2021 Jun/30/2021
  • Alternative id - 25/20
  • Interventions - Drug: Hydroxychloroquine Sulfate|Drug: Bromhexine 8 MG
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - National Institute of Rehabilitation, Luis Guillermo Ibarra Ibarra, Mexico City, Cdmx, Mexico
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Triple (Participant, Care Provider, Investigator)|Primary Purpose: Prevention
  • Enrollment - 214
  • Age - 18 Years to 59 Years   (Adult)
  • Outcome measures - Quantification of the expression of mRNA SARS-CoV-2 and presence or absence of antibodies anti-SARS-CoV-2
NCT04359680 Trial to Evaluate the Efficacy and Safety of Nitazoxanide (NTZ) for Pre- and Post Exposure Prophylaxis of COVID-19 and Other Viral Respiratory Illnesses (VRI) in Healthcare Workers and Others at Increased Risk of SARS-CoV-2 Infection Active, not recruiting Phase 3 May/13/2020 Mar/29/2021
  • Alternative id - RM08-3007
  • Interventions - Drug: Nitazoxanide|Drug: Placebo|Dietary Supplement: Vitamin Super B-Complex
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - HealthStar Research LLC, Hot Springs, Arkansas, United States|So Cal Clinical Research, Huntington Beach, California, United States|Long Beach Clinical Trials, LLC, Long Beach, California, United States|Meris Clinical Research, Brandon, Florida, United States|Invesclinica US LLC, Fort Lauderdale, Florida, United States|The Chappel Group Research, Kissimmee, Florida, United States|New Horizon Research Center, Miami, Florida, United States|Clinical Neuroscience Solutions, Inc., Orlando, Florida, United States|DMI Research, Pinellas Park, Florida, United States|Tampa General Hospital, Tampa, Florida, United States|Chicago Clinical Research Institute, Inc., Chicago, Illinois, United States|Chicago Medical Research Institute, Inc., Chicago, Illinois, United States|Quad Clinical Research, Chicago, Illinois, United States|Chicago Medical Research, LLC, Hazel Crest, Illinois, United States|Centex Studies, Inc., Lake Charles, Louisiana, United States|Vida Clinical Studies, Dearborn, Michigan, United States|Beacom Family Health Connection, Fremont, Nebraska, United States|North Jersey Community Research Initiative, Newark, New Jersey, United States|RH Medical Urgent Care Professional PLLC, Bronx, New York, United States|Integrative Clinical Trials LLC, Brooklyn, New York, United States|The New York Center for Travel and Tropical Medicine, New York, New York, United States|Centex Studies, Inc., Houston, Texas, United States|SMS Clinical Research LLC, Mesquite, Texas, United States|LinQ Research LLC, Pearland, Texas, United States|Rio Grande Valley Clinical Research Institute, Pharr, Texas, United States|BFHC Research, San Antonio, Texas, United States
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Triple (Participant, Care Provider, Investigator)|Primary Purpose: Prevention
  • Enrollment - 1407
  • Age - 18 Years to 120 Years   (Adult, Older Adult)
  • Outcome measures - The proportion of subjects with symptomatic laboratory-confirmed COVID-19 identified after start of treatment and before the end of the 6-week treatment period.|The proportion of subjects with symptomatic laboratory-confirmed VRI identified after the start of treatment and before the end of the 6-week treatment period.
NCT04456426 Characteristics of Patients and Healthcare Workers With COVID-19 in Meta State, Colombia Not yet recruiting Jul/01/2020 Aug/01/2020
  • Alternative id - GRIVI_2020_01COVID
  • Interventions -
  • Study type - Observational
  • Study results - No Results Available
  • Locations -
  • Study designs - Observational Model: Ecologic or Community|Time Perspective: Retrospective
  • Enrollment - 250
  • Age - up to 120 Years   (Child, Adult, Older Adult)
  • Outcome measures - Mortality|ICU admission|Mechanical ventilation|ICU length of stay|Hospital length of stay|Days of mechanical ventilation
NCT04779424 Prevalence and Incidence of Antibodies Against SARS-CoV-2 Among Primary Healthcare Providers in Belgium (COVID-19) Active, not recruiting Nov/15/2020 Jun/30/2022
  • Alternative id - OZ8478
  • Interventions - Other: POCT
  • Study type - Observational
  • Study results - No Results Available
  • Locations - Niels Adriaenssens, Wilrijk, Antwerp, Belgium
  • Study designs - Observational Model: Cohort|Time Perspective: Prospective
  • Enrollment - 5000
  • Age - Child, Adult, Older Adult
  • Outcome measures - Prevalence of antibodies against SARS-CoV-2 in primary health care providers - T1|Prevalence of antibodies against SARS-CoV-2 in primary health care providers - T2|Prevalence of antibodies against SARS-CoV-2 in primary health care providers - T3|Prevalence of antibodies against SARS-CoV-2 in primary health care providers - T4|Prevalence of antibodies against SARS-CoV-2 in primary health care providers - T5|Prevalence of antibodies against SARS-CoV-2 in primary health care providers - T6|Prevalence of antibodies against SARS-CoV-2 in primary health care providers - T7|Prevalence of antibodies against SARS-CoV-2 in primary health care providers - T8|Prevalence of antibodies against SARS-CoV-2 in primary health care providers - T9|Monthly incidence of antibodies against SARS-CoV-2 in primary health care providers|Annual incidence of antibodies against SARS-CoV-2 in primary health care providers|Longevity of antibodies against SARS-CoV-2 in primary health care providers|Proportion of asymptomatic cases among primary health care providers with antibodies against SARS-CoV-2|Determinants of of SARS-CoV-2 infection among primary health care providers|Validation of a self-administered and self-reported serological point of care test in a primary care setting|Familiarisation with a self-administered and self-reported serological point of care test among primary health care providers
NCT04936893 Effects of Mindfulness Practice on Healthcare Workers Active, not recruiting Not Applicable May/19/2020 Jul/31/2021
  • Alternative id - YaleNUS
  • Interventions - Behavioral: Mindfulness Practice|Behavioral: Cognitive training
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Yle-NUS College, Singapore, Singapore
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Single (Investigator)|Primary Purpose: Supportive Care
  • Enrollment - 80
  • Age - 21 Years to 60 Years   (Adult)
  • Outcome measures - Depression|Anxiety|Fear of COVID-19|Burnout, Compassion Satisfaction, and Secondary Traumatic Stress|Sleep Quality|Working Memory|PTSD symptoms|Trait Mindfulness|Self-Compassion
NCT04819165 Healthcare-associated Infections in Severe COVID-19 During 2020 Completed Mar/01/2020 Jan/31/2021
  • Alternative id - 5/2021
  • Interventions - Other: COVID-19
  • Study type - Observational
  • Study results - No Results Available
  • Locations - Sanatorio Anchorena de San Martin, San Martín, Buenos Aires, Argentina
  • Study designs - Observational Model: Cohort|Time Perspective: Retrospective
  • Enrollment - 252
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Incidence of health care associated infections in each group.|The most frequent pathogens in this population associated with Incidence of health care associated infections.|Possible factors associated with Incidence of health care associated infections.|mortality in UCI|Days of ICU stay|Days of mechanical ventilation
NCT04411576 Current and Past SARS-CoV-2 Infection and COVID-19 in Healthcare Completed Apr/23/2020 Dec/31/2020
  • Alternative id - COVID-19 Studien
  • Interventions - Diagnostic Test: Throat swab sample for measuring current infection with SARS-CoV-2|Diagnostic Test: Blood sample for serology to measure past infection with SARS-CoV-2
  • Study type - Observational
  • Study results - No Results Available
  • Locations - Karolinska University Hospital, Stockholm, Sweden
  • Study designs - Observational Model: Cohort|Time Perspective: Prospective
  • Enrollment - 26326
  • Age - 18 Years to 99 Years   (Adult, Older Adult)
  • Outcome measures - SARS-CoV-2 infection
NCT04341519 Psychological Burden in ICU Survivors of Severe COVID-19 Pneumonia, Their Relatives and Their Healthcare Providers Recruiting Apr/06/2020 Dec/31/2021
  • Alternative id - APHP200389
  • Interventions - Behavioral: PTSD|Behavioral: Burnout
  • Study type - Observational
  • Study results - No Results Available
  • Locations - Saint-Louis Hospital, Paris, Ile De France, France|Cochin, Paris, France|Pitié Salpetrière, Paris, France
  • Study designs - Observational Model: Cohort|Time Perspective: Prospective
  • Enrollment - 1464
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - PTSD Family members sup 22|PTSD Family members|PTSD Patients|PTSD healthcare providers|HADS Family members|HADS Patients|SF36 Patients|Questionnaire Family members|Questionnaire Patients|Questionnaire healthcare providers|MBI healthcare providers|Karasec instrument healthcare providers
NCT04344145 Exhaustion and Needs in Frontline COVID-19 Healthcare Workers: Cross-sectional Study in a Belgian Population Completed Apr/16/2020 May/29/2020
  • Alternative id - PSY-ENCOVID19
  • Interventions -
  • Study type - Observational
  • Study results - No Results Available
  • Locations - Hôpital de Warquignies, Boussu, Hainaut, Belgium|Hôpital de Jolimont, Haine-Saint-Paul, Hainaut, Belgium|Hôpital de Lobbes, Lobbes, Hainaut, Belgium|Hôpital de Mons, Mons, Hainaut, Belgium|Erasme Hospital CUB, Brussels, Belgium
  • Study designs - Observational Model: Case-Control|Time Perspective: Cross-Sectional
  • Enrollment - 693
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Burnout|Emotional Distress|Insomnia|Needs and difficulties in work situations
NCT04393818 Mobile Phone Based Intervention to Protect Mental Health in Healthcare Workers at Frontline Against COVID19 Completed Phase 3 May/05/2020 Aug/24/2020
  • Alternative id - COVID-19/06
  • Interventions - Behavioral: Intervention App
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Ignacio Ricci-Cabello, Palma De Mallorca, Balearic Islands, Spain
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Triple (Participant, Care Provider, Outcomes Assessor)|Primary Purpose: Supportive Care
  • Enrollment - 560
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Depression, anxiety and stress|Post-traumatic stress syndrome|Insomnia|Self Efficacy
NCT04346329 Immune Monitoring of Prophylactic Effect of Hydroxychloroquine in Healthcare Providers Highly Exposed to COVID-19 Withdrawn Phase 3 Mar/30/2020 Oct/30/2020
  • Alternative id - UNAL-COVID-CP
  • Interventions - Drug: Hydroxychloroquine|Drug: Placebo oral tablet
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Facultad de Medicina - Universidad Nacional de Colombia, Bogota, Cundinamarca, Colombia|Universidad Nacional de Colombia, Bogota, Cundinamarca, Colombia
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Double (Participant, Care Provider)|Primary Purpose: Prevention
  • Enrollment - 0
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Adverse effects|Immune-score|COVID-19 prevention|Clinical response
NCT04587245 The Provider Insurance Revenue Study in Healthcare Providers in the United States of America Recruiting Oct/01/2020 Oct/15/2022
  • Alternative id - PIRStudy
  • Interventions - Other: Online questionnaire and interviews
  • Study type - Observational
  • Study results - No Results Available
  • Locations - University of California Irvine Beall Applied Innovation, Irvine, California, United States
  • Study designs - Observational Model: Cohort|Time Perspective: Retrospective
  • Enrollment - 100
  • Age - Child, Adult, Older Adult
  • Outcome measures - Change in monthly income of healthcare Providers from baseline to 6, 9 and 12 months after the beginning of the COVID-related events|Differences in Accounts Receivable (AR) due to claim denials over 4 quarters: Differences in recoveries of AR.
NCT04350931 Application of BCG Vaccine for Immune-prophylaxis Among Egyptian Healthcare Workers During the Pandemic of COVID-19 Not yet recruiting Phase 3 Apr/20/2020 Dec/01/2020
  • Alternative id - FMASU P19a/ 2020
  • Interventions - Biological: intradermal injection of BCG Vaccine|Other: placebo
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Faculty of Medicine Ain Shams University Research Institute- Clinical Research Center, Cairo, Non-US, Egypt
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Single (Participant)|Primary Purpose: Prevention
  • Enrollment - 900
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - incidence of confirmed COVID-19|Effectiveness of BCG vaccine
NCT04703777 Relationship Between Social Status and Use of Healthcare Services During the Confinement Period Linked to the COVID-19 Epidemic Completed Apr/04/2020 Apr/04/2021
  • Alternative id - 7814
  • Interventions -
  • Study type - Observational
  • Study results - No Results Available
  • Locations - Adult Emergency Department - Strasbourg University Hospitals, Strasbourg, France
  • Study designs - Observational Model: Case-Only|Time Perspective: Retrospective
  • Enrollment - 500
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Retrospective study on the relationship between social status and use of healthcare services during the confinement period linked to the COVID-19 epidemic in Bas-Rhin, France
NCT04887116 Piloting Virtual Reality Environments to Treat PTSD in Healthcare Workers and Patients Consequent to the COVID-19 Pandemic Not yet recruiting Early Phase 1 Jun/01/2022 Dec/01/2022
  • Alternative id - 20-04021926
  • Interventions - Behavioral: Virtual Reality Exposure Therapy
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Weill Cornell Medicine, New York, New York, United States
  • Study designs - Allocation: N/A|Intervention Model: Single Group Assignment|Masking: None (Open Label)|Primary Purpose: Treatment
  • Enrollment - 20
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Change in Clinician Administered PTSD Score (CAPS-V)|Feasibility Indicator: Recruitment|Feasibility Indicator: Enrollment|Feasibility Indicator: Retention|Acceptability Indicator: Satisfaction|Change in Anxiety Symptoms measured by the Generalized Anxiety Disorder 7-Item Scale|Change in Depressive Symptoms measured by the Quick Inventory of Depressive Symptomatology|Change in score on the Pittsburgh Sleep Quality Index (PSQI)|Change in score on the PTSD Checklist for DSM-5 (PCL-5)|Change in Score on the Occupational Stress Inventory Revised (OSI-R)|Change in score on the Modified Moral Injury Events Scale|Change in score on the Sheehan Disability Scale (SDS)|Change in score on the Social Adjustment Scale (SAS)|Change in score on the Moral Distress Scale|Change in score on the Quality of Life Inventory
NCT05069389 Registry of Management Strategies for Patients With COVID-19 in Healthcare Establishments Recruiting Jun/02/2020 Dec/31/2022
  • Alternative id - EDS_2020_HOPICOV
  • Interventions - Other: Data collection
  • Study type - Observational
  • Study results - No Results Available
  • Locations - Hospital Center Emile Roux, Le Puy-en-Velay, France
  • Study designs - Observational Model: Cohort|Time Perspective: Retrospective
  • Enrollment - 2071
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Describe management strategies implemented by healthcare establishments for patients with covid-19, depending on the evolution of scientific knowledge and recommendations for specific treatments.|Describe management strategies to take care depending on the patient|Compare patients' clinical course who received different management strategies|Evaluate the cost of the care|Evaluate the effectiveness of the care
NCT05239429 Improving the Mental Health and Well Being of Healthcare Providers Through the Transcendental Meditation Technique Completed Not Applicable Jun/30/2020 Jun/30/2021
  • Alternative id - CCCR 01-2020
  • Interventions - Behavioral: Transcendental Meditation Technique
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - The Center for Clinical and Cosmetic Research, Aventura, Florida, United States
  • Study designs - Allocation: Non-Randomized|Intervention Model: Parallel Assignment|Masking: None (Open Label)|Primary Purpose: Supportive Care
  • Enrollment - 130
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Change in Maslach Burnout Inventory- Human Services Survey (MBI-HSS) Score from Baseline|Change from Baseline in Insomnia Severity Index (ISI) Score|Change from Baseline in Brief Symptom Inventory 18 (BSI 18) Score|Change in Warwick-Edinburgh Mental Well Being Scale (WEMWBS) Score from Baseline
NCT04701710 Prophylaxis Covid-19 in Healthcare Agents by Intensive Treatment With Ivermectin and Iota-carrageenan Completed Phase 1|Phase 2 Oct/15/2020 Dec/31/2020
  • Alternative id - 5076-410-CH2020
  • Interventions - Drug: Ivermectin / Iota-Carrageenan
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - SI.PRO.SA, Ministerio de Salud Pública, Tucumán, Argentina
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: None (Open Label)|Primary Purpose: Prevention
  • Enrollment - 300
  • Age - 18 Years to 60 Years   (Adult)
  • Outcome measures - Pearson's Chi-square and proportion test.|Odd Ratio, probabilistic test|Logistic regression test
NCT04337541 Reduction in COVID-19 Infection Using Surgical Facial Masks Outside the Healthcare System Completed Not Applicable Apr/02/2020 Jun/02/2020
  • Alternative id - 2020-04-02
  • Interventions - Other: Surgical facial mask
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Rigshospitalet, Copenhagen, Denmark
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: None (Open Label)|Primary Purpose: Prevention
  • Enrollment - 6000
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - The primary endpoint is the difference in SARS-CoV-2 infection between the two groups after 1 months and is a combined endpoint consisting of primary outcome components 1, 2 and/or 3:|Positive oropharyngeal/nasal swab (PCR);
NCT04483635 PRevention of COVID-19 With Oral Vitamin D Supplemental Therapy in Essential healthCare Teams Terminated Phase 3 Feb/08/2021 May/25/2021
  • Alternative id - MP-21-2021-3044
  • Interventions - Dietary Supplement: Placebo|Dietary Supplement: Vitamin D
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - CHUM, Montreal, Quebec, Canada|CHU Sainte-Justine (CHUSJ), Montreal, Quebec, Canada
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)|Primary Purpose: Prevention
  • Enrollment - 34
  • Age - 18 Years to 69 Years   (Adult, Older Adult)
  • Outcome measures - Change in incidence of laboratory-confirmed COVID-19 infection|Distribution of disease severity|Duration of symptoms in COVID-19 positive participants|Number of participants with COVID-19 positive IgG serology|Number of workday absences due to COVID-19 suspected/confirmed infection|Number of workday absences for any reason|Adverse health events
NCT05037253 COVID-19 Morbidity in Healthcare Workers and Vitamin D Supplementation Completed Phase 4 Oct/30/2020 May/30/2021
  • Alternative id - 0811-20-01C
  • Interventions - Drug: Vitamin D
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health of the Russian Federation, Saint Petersburg, Russian Federation
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: None (Open Label)|Primary Purpose: Treatment
  • Enrollment - 128
  • Age - 18 Years to 65 Years   (Adult, Older Adult)
  • Outcome measures - SARS-CoV-2 antibodies (IgG)|Positive PCR test|Serum 25(OH)D level|COVID-19 clinical features|CT data
NCT04979208 Impact of Changes in the Use of Care and Reorganization of the Healthcare System Linked to the Covid-19 Outbreak on the Quality of Care Pathways of Patients Suffering From Acute Myocardial Infarction and Stroke in Aquitaine (AVICOVID) Completed Jul/15/2020 Jul/09/2021
  • Alternative id - CHUBX 2020/39
  • Interventions -
  • Study type - Observational
  • Study results - No Results Available
  • Locations - CHU Bordeaux, Bordeaux, France
  • Study designs - Observational Model: Cohort|Time Perspective: Retrospective
  • Enrollment - 9218
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Delay for AMI patient|Delay for stroke patient
NCT05114655 Aromatherapy for Stress and Burnout Among Healthcare Providers Recruiting Not Applicable Nov/11/2021 Jan/31/2022
  • Alternative id - 21-10-110
  • Interventions - Other: Herbaceous Essential Oil Blend|Other: Citrus Essential Oil Blend|Other: Inert Oil
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Franklin Health Research Center, Franklin, Tennessee, United States
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Double (Participant, Care Provider)|Primary Purpose: Supportive Care
  • Enrollment - 125
  • Age - 20 Years to 59 Years   (Adult)
  • Outcome measures - Post-intervention score on the Maslach Burnout Inventory for Health Personnel on day 7|Post-intervention score on the Profile of Mood States, abbreviated version on day 7|Post-intervention score on the Depression Anxiety Stress Scale (DASS) on day 7
NCT04333225 Hydroxychloroquine in the Prevention of COVID-19 Infection in Healthcare Workers Completed Phase 2 Apr/03/2020 Jun/30/2020
  • Alternative id - 020-132
  • Interventions - Drug: Hydroxychloroquine
  • Study type - Interventional
  • Study results - Has Results
  • Locations - Baylor University Medical Center, Dallas, Texas, United States
  • Study designs - Allocation: Non-Randomized|Intervention Model: Parallel Assignment|Masking: None (Open Label)|Primary Purpose: Prevention
  • Enrollment - 221
  • Age - 18 Years to 75 Years   (Adult, Older Adult)
  • Outcome measures - Number of Participants Infected With COVID-19 or COVID-19 Like Illness During the Trial|Time From Study Initiation Until the Occurrence of COVID-19 or COVID-19 Like Illness or Being Censored
NCT04413058 Menstrual Cycle Characteristics of Healthcare Professionals Completed Apr/10/2020 Sep/10/2020
  • Alternative id - HNEAH KAEK 2020/KK/|Ministry of Health
  • Interventions -
  • Study type - Observational
  • Study results - No Results Available
  • Locations - University of Health Sciences Turkey, Istanbul, Turkey
  • Study designs - Observational Model: Case-Crossover|Time Perspective: Prospective
  • Enrollment - 260
  • Age - 18 Years to 47 Years   (Adult)
  • Outcome measures - Rate of irregular menstrual cycle|Length of cycle|Rate of prolonged bleeding|Amount of flow|Rate of dysmenorrhea|The number of difference in menstrual cycle length|The number of difference in bleeding days|The number of difference in amount of flow
NCT04728594 Emails Promoting COVID-19 Vaccination Among Healthcare Workers Completed Not Applicable Jan/15/2021 Jan/20/2021
  • Alternative id - 2021-0128
  • Interventions - Behavioral: Social Proof|Behavioral: Reframing|Behavioral: Scarcity Message
  • Study type - Interventional
  • Study results - Has Results
  • Locations - Geisinger, Danville, Pennsylvania, United States
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Double (Participant, Care Provider)|Primary Purpose: Prevention
  • Enrollment - 9566
  • Age - Child, Adult, Older Adult
  • Outcome measures - Number of Employees Who Scheduled Vaccination Appointments After 3 Days|Number of Employees Who Opened Emails After 3 Days|Number of Employees Who Clicked Scheduling Links After 3 Days
NCT04766333 New Jersey Healthcare Essential Worker Outreach and Education Study - Testing Overlooked Occupations Recruiting Not Applicable May/03/2021 Aug/01/2022
  • Alternative id - 2020002549
  • Interventions - Behavioral: Healthcare Worker Focused Outreach|Behavioral: Community Organization Led Outreach
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Rutgers University, New Brunswick, New Jersey, United States
  • Study designs - Allocation: Non-Randomized|Intervention Model: Parallel Assignment|Masking: None (Open Label)|Primary Purpose: Health Services Research
  • Enrollment - 2000
  • Age - 4 Years and older   (Child, Adult, Older Adult)
  • Outcome measures - Number of participants who complete COVID-19 testing
NCT04327206 BCG Vaccination to Protect Healthcare Workers Against COVID-19 Active, not recruiting Phase 3 Mar/30/2020 Mar/30/2022
  • Alternative id - 62586|U1111-1256-4104|INV-017302
  • Interventions - Drug: BCG Vaccine|Drug: 0.9%NaCl
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - St Vincent's Hospital, Sydney, Sydney, New South Wales, Australia|Prince of Wales Hospital, Sydney, New South Wales, Australia|Sydney Children's Hospital, Randwick, Sydney, New South Wales, Australia|The Children's Hospital at Westmead, Sydney, New South Wales, Australia|Westmead Hospital, Sydney, New South Wales, Australia|Royal Adelaide Hospital, Adelaide, South Australia, Australia|Women's and Children's Hospital, North Adelaide, South Australia, Australia|Royal Children's Hospital, Melbourne, Victoria, Australia|Epworth Richmond, Melbourne, Victoria, Australia|Monash Health- Monash Medical Centre, Melbourne, Victoria, Australia|Fiona Stanley Hospital, Murdoch, Western Australia, Australia|Perth Children's Hospital, Perth, Western Australia, Australia|Sir Charles Gairdner Hospital, Perth, Western Australia, Australia|Fundação de Medicina Tropical Dr Heitor Vieira Dourado (FMT-HVD), Manaus, Amazonas, Brazil|Santa Casa Hospital, Campo Grande, Mato Grosso Do Sul, Brazil|CASSEMS Hospital, Campo Grande, Mato Grosso Do Sul, Brazil|Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso Do Sul, Brazil|Hospital Regional de Mato Grosso do Sul, Campo Grande, Mato Grosso Do Sul, Brazil|Centro de Estudos da Saúde do Trabalhador e Ecologia Humana, Rio de Janeiro, RJ, Brazil|Centro de Referência Prof Hélio Fraga, Rio de Janeiro, RJ, Brazil|Noord West Ziekenhuis, Alkmaar, Netherlands|Rijnstate Hospital, Arnhem, Netherlands|Amphia Hospital, Breda, Netherlands|St Antonius Hospital, Nieuwegein, Netherlands|Radboud UMC, Nijmegen, Netherlands|University hospital in Utrecht (UMCU), Utrecht, Netherlands|University Hospital German Trias I Pujol, Badalona, Barcelona, Spain|Mutua Terrassa Univeristy Hospital, Terrassa, Barcelona, Spain|University Hospital Cruces, Barakaldo, Bizkaia, Spain|Marqués de Valdecilla University Hospital, Santander, Spain|University Hospital Virgen Macarena, Sevilla, Spain|Teign Estuary Medical Group, Teignmouth, Devon, United Kingdom|Ide Lane Surgery, Alphington, Exeter, United Kingdom|St Leonard's Practice, St Leonards, Exeter, United Kingdom|Travel Clinic, Exeter, United Kingdom|Royal Devon and Exeter NHS Foundation Trust, Exeter, United Kingdom
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Double (Participant, Outcomes Assessor)|Primary Purpose: Prevention
  • Enrollment - 10078
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - COVID-19 disease incidence|Severe COVID-19 disease incidence|COVID-19 incidence by 12 months|Severe COVID-19 incidence by 12 months|Time to first symptom of COVID-19|Episodes of COVID-19|Asymptomatic SARS-CoV-2 infection|Work absenteeism due to COVID-19|Bed confinement due to COVID-19|Symptom duration of COVID-19|SARS-CoV-2 pneumonia|Oxygen therapy with SARS-CoV-2|Critical care admissions with SARS-CoV-2|Critical care admission duration with SARS-CoV-2|Mechanical ventilation with SARS-CoV-2|Mechanical ventilation duration with SARS-CoV-2|Hospitalisation duration with COVID-19|Mortality with SARS-CoV-2|Fever or respiratory illness|Episodes of fever or respiratory illness|Work absenteeism due to fever or respiratory illness|Bed confinement due to fever or respiratory illness|Symptom duration of fever or respiratory illness|Pneumonia|Oxygen therapy|Critical care admissions|Mechanical ventilation|Mortality|Hospitalisation duration with fever or respiratory illness|Unplanned work absenteeism|Local and systemic adverse events to BCG vaccination in healthcare workers
NCT04345653 Hydroxychloroquine as Chemoprevention for COVID-19 for High Risk Healthcare Workers Completed Phase 2 Apr/14/2020 May/10/2021
  • Alternative id - Pro2020-0356
  • Interventions - Drug: Hydroxychloroquine Sulfate (HCQ)
  • Study type - Interventional
  • Study results - Has Results
  • Locations - Hackensack Meridian Health - JFK Medical Center, Edison, New Jersey, United States
  • Study designs - Allocation: N/A|Intervention Model: Single Group Assignment|Masking: None (Open Label)|Primary Purpose: Prevention
  • Enrollment - 48
  • Age - 18 Years to 99 Years   (Adult, Older Adult)
  • Outcome measures - Recruitment Feasibility|Resource Utilization|Safety as Reflected on the Number and Severity of Adverse Events and Serious Adverse Events|Early Feasibility as Reflected on the Number of Participants Contracting COVID-19 (10% or Less) in Comparison to the Expected 30% as Per CDC.
NCT04845984 Evaluation of the Prevalence of SARS-CoV-2 Infection in the Healthcare Workers (HCWs) in Four Hospital of the Alpine Region Completed Sep/01/2020 Jan/15/2021
  • Alternative id - 20-12
  • Interventions -
  • Study type - Observational
  • Study results - No Results Available
  • Locations - Ch Annecy Genevois, Pringy, France
  • Study designs - Observational Model: Cohort|Time Perspective: Retrospective
  • Enrollment - 3500
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - SARS-CoV-2 prevalency among hospital health care professionals
NCT04374942 Does Hydroxychloroquine Before & During Patient Exposure Protect Healthcare Workers From Coronavirus? Terminated Phase 3 Apr/30/2020 Mar/31/2021
  • Alternative id - HEROs Protocol 1.5|ISRCTN14326006
  • Interventions - Drug: Hydroxychloroquine|Drug: Placebo oral tablet
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - University Health Network, Toronto, Ontario, Canada
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)|Primary Purpose: Prevention
  • Enrollment - 13
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Microbiologically confirmed COVID-19 (SARS-CoV-2 infection)|Adverse events|Symptom duration of COVID-19|Days of hospitalization attributable to COVID-19|Respiratory failure requiring ventilatory support attributable to COVID-19|Mortality|Impact on work eligibility|Seropositivity|Short-term psychological impact
NCT04452773 Clinical Trial to Evaluate the Efficacy of Food Supplement Manremyc® Against SARS- COV-2 Infection (COVID-19) in Healthcare Workers Recruiting Not Applicable Jul/14/2020 Dec/01/2021
  • Alternative id - MANRECOVID19
  • Interventions - Dietary Supplement: Manremyc|Dietary Supplement: Placebo
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - CAP Cornellà (La Gavarra), Cornellà De Llobregat, Barcelona, Spain|CAP Maresme, Mataró, Barcelona, Spain|Cap Sant Fèlix, Sabadell, Barcelona, Spain|EAP Riu Nord, Santa Coloma De Gramenet, BArcelona, Spain|Hospital Universitari Germans Trias i Pujol UBP Riscos Laborals, Badalona,, Badalona, Spain
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)|Primary Purpose: Prevention
  • Enrollment - 315
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Documented cumulative incidence of SARS-CoV-2 infection|Documented sick leave for SARS-CoV-2|days off work due to the quarantine|Quarantine imposed by close contact outside the center with SARS-CoV-2 positive|Fever|Cumulative incidence of self-reported acute respiratory symptoms|Number of days of self-reported acute respiratory symptoms|Incidence of pneumonia|Cumulative incidence of death from documented SARS-CoV-2 infection|Incidence of admission to ICU|Days in IUC|Incidence of mechanical ventilation|Incidence of hospital admissions|Days of hospitalization|Levels of IgG|Levels of IgM|Levels of SARS-CoV-2 antibodies at the end of the study period
NCT04980326 A Scalable Psychological Intervention to Reduce Psychological Distress Among Healthcare Workers Recruiting Not Applicable Nov/01/2021 Aug/31/2022
  • Alternative id - RESPOND WP4 RCT
  • Interventions - Behavioral: Doing What Matters (DWM)|Behavioral: Problem Management Plus (PM+)|Behavioral: Psychological First Aid (PFA)
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Parc Sanitari Sant Joan de Déu, Sant Boi De Llobregat, Barcelona, Spain|Hospital Universitario La Paz, Madrid, Spain
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Single (Outcomes Assessor)|Primary Purpose: Supportive Care
  • Enrollment - 212
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Patient Health Questionnaire Anxiety and Depression Scale (PHQ-ADS)|Patient Health Questionnaire (PHQ-9)|Generalized Anxiety Disorder (GAD-7) scale|Posttraumatic Stress Disorder (PTSD) Checklist for Diagnostic and Statistical Manual of Mental Disorders (DSM-5) (PCL-5) - 8-item version|EuroQol 5-dimensional descriptive system - 5-level version (EQ-5D-5L)|Client Service Receipt Inventory (CSRI) - RESPOND adaptation
NCT05175963 Surveillance Among Healthcare Workers for SARS-Coronavirus-2 Infection Recruiting Apr/22/2020 Apr/30/2022
  • Alternative id - 200405
  • Interventions -
  • Study type - Observational
  • Study results - No Results Available
  • Locations - Chris Hani Baragwanath Academic Hospital, Johannesburg, GP, South Africa
  • Study designs - Observational Model: Cohort|Time Perspective: Prospective
  • Enrollment - 1000
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - To determine the prevalence of symptomatic and asymptomatic SARS-CoV-2 infections among HCW.|To define the duration of viral "shedding".|To do sero-epidemiology assessment.|To analyse immune responses to SARS-CoV-2 infection.|To investigate the possibility of viral re-infection in this population during the study period.|To establish if common cold coronaviruses (CCCV) immunity confers protection against SARS-CoV-2 infection or disease severity|To evaluate COVID-19 vaccine effectiveness (VE) amongst HCWs, against any PCR-confirmed SARS-CoV-2 infection.|To measure humoral and cell mediated immune responses to COVID-19 vaccines stratified by previous SARS-CoV-2 infection.
NCT04816708 A Self-directed Mobile Mindfulness Intervention to Address Distress and Burnout in Frontline Healthcare Workers Completed Not Applicable May/19/2021 Feb/04/2022
  • Alternative id - Pro00107657
  • Interventions - Behavioral: LIFT Mindfulness
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Duke University Medical Center, Durham, North Carolina, United States
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: None (Open Label)|Primary Purpose: Treatment
  • Enrollment - 102
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Intervention completion|Sessions completed|Survey completion|Change in Patient Health Questionnaire-9 Item scale (PHQ-9)|Change in Generalized Anxiety Disorder 7-item scale (GAD-7)|Change in Perceived Stress Scale (PSS-4)|Change in Maslach Burnout Index (MBI)
NCT04709003 Covid-19 Vaccine Effectiveness in Healthcare Personnel in Clalit Health Services in Israel (CoVEHPI) Recruiting Dec/23/2020 Jun/01/2022
  • Alternative id - 1051-20-RMC-C
  • Interventions - Diagnostic Test: Serologic test|Diagnostic Test: Respiratory swabs
  • Study type - Observational
  • Study results - No Results Available
  • Locations - Haemek Medical Center, Afula, Israel|Soroka Medical Center, Be'er Sheva, Israel|Meir Medical Center, Kefar Saba, Israel|Beilinson hospital, Petach Tikva, Israel|Schneider Children's Medical Center of Israel, Petah tikva, Israel|Kaplan Medical Center, Reẖovot, Israel
  • Study designs - Observational Model: Cohort|Time Perspective: Prospective
  • Enrollment - 4504
  • Age - 18 Years to 120 Years   (Adult, Older Adult)
  • Outcome measures - COVID-19 vaccine effectiveness (VE)|Symptomatic SARS-CoV-2 infection in vaccinated vs. unvaccinated healthcare workers|asymptomatic SARS-CoV-2 infection in vaccinated vs. unvaccinated healthcare workers|Duration of effectiveness of the vaccine|Vaccine Effectiveness by age|Vaccine Effectiveness by comorbidity|Vaccine effectiveness in persons previously infected with SARS-CoV-2 virus|VE by degree of exposure to COVID-19 patients|VE by different SARS-CoV-2 variants|Vaccine effectiveness of one dose compared to two doses|Compartive vaccine Effectiveness of different vaccine brands
NCT04453488 Clinical Trial to Evaluate the Efficacy of RUTI® Against SARS-COV-2 Infection (COVID-19) in Healthcare Workers Not yet recruiting Phase 3 Jul/30/2020 Dec/01/2020
  • Alternative id - RUTICOVID19
  • Interventions - Biological: RUTI® vaccine|Biological: Placebo
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Hospital Universitari Germans Trias i Pujol UBP Riscos Laborals, Badalona, Barcelona, Spain|Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)|Primary Purpose: Prevention
  • Enrollment - 315
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Documented cumulative incidence of SARS-CoV-2 infection|Sick leave for SARS-CoV-2|Days off work due to the quarantine|Quarantine imposed by close contact outside the center with SARS-CoV-2 positive|Professional category|Fever|Incidence of self-reported acute respiratory symptoms|Days of self-reported acute respiratory symptoms|Incidence of pneumonia|Incidence of death from SARS-CoV-2 infection|Incidence of admissions to Intensive Care Unit (ICU)|Days in ICU|Incidence of mechanical ventilation|Incidence of hospital admissions|Days of hospitalization|Incidence of SARS-CoV-2 antibodies|Types of antibodies detected|Levels of SARS-CoV-2 antibodies
NCT04352764 ANTIBODY BASED TESTS FOR SARSCoV-2 COVID-19) - Evaluation of Patients and Healthcare Providers in the Confines of Healthcare Settings Recruiting Mar/27/2020 Jan/31/2021
  • Alternative id - TCAI_COVID-19
  • Interventions - Diagnostic Test: CoronaCideTM COVID-19 IgM/IgG Rapid Test and Premier Biotech COVID-19 IgM/IgG Rapid Test
  • Study type - Observational
  • Study results - No Results Available
  • Locations - St. David's Medical Center, Austin, Texas, United States
  • Study designs - Observational Model: Case-Control|Time Perspective: Prospective
  • Enrollment - 5000
  • Age - Child, Adult, Older Adult
  • Outcome measures - prevalence of COVID-19 exposure|correlation between the test results with the presence or lack of COVID-19 symptoms or illness|correlate pre-existing risk factors with test results and baseline symptoms|correlate subsequent healthcare utilization with test results and baseline symptoms
NCT04913701 COVID-19 Epidemiological Surveillance on Healthcare Workers and Patients in a Rehabilitation Medicine Facility Completed Mar/21/2020 Dec/31/2020
  • Alternative id - 20/09
  • Interventions - Other: Observation group 1
  • Study type - Observational
  • Study results - No Results Available
  • Locations - IRCCS San Raffaele Pisana, Rome, Italy
  • Study designs - Observational Model: Cohort|Time Perspective: Prospective
  • Enrollment - 500
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Number of participants with positive RT-PCR against SARS-CoV2|Number of participants with qualitative IgM/IgG positive results
NCT04356560 COVID-19 Surveillance of Patients and Healthcare Workers in a Hospital Department Enrolling by invitation Mar/23/2020 Dec/31/2020
  • Alternative id - DT P-2020-353
  • Interventions - Diagnostic Test: COVID-19 test, polymerase chain reaction for SARS-CoV-2
  • Study type - Observational
  • Study results - No Results Available
  • Locations - Rigshospitalet University Hospital of Copenhagen, Copenhagen, Denmark
  • Study designs - Observational Model: Cohort|Time Perspective: Prospective
  • Enrollment - 300
  • Age - Child, Adult, Older Adult
  • Outcome measures - Incidence of healthcare workers with SARS-CoV-2|Incidence of ENT patients with SARS-CoV-2|Development of SARS-CoV-2 antibodies among healthcare workers|Sensitivity and specificity of a COVID-19 screening symptom questionnaire among healthcare workers|SARS CoV-2 and bacterial super infections in upper respiratory airways
NCT04452643 Efficacy of BACMUNE (MV130) in the Prevention of Disease Due to COVID-19 Infection in Healthcare Personnel Withdrawn Phase 3 Oct/01/2020 Dec/01/2021
  • Alternative id - MV130-SLG-037
  • Interventions - Biological: BACMUNE (MV130)|Other: Placebo
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Instituto Nacional de Enfermedades Respiratorias (INER), Ciudad de México, Mexico|Hospital General de Pachuca, Pachuca de Soto, Mexico|Hospital de Ciudad Valles, San Luis Potosí, Mexico
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Triple (Participant, Care Provider, Investigator)|Primary Purpose: Prevention
  • Enrollment - 0
  • Age - 18 Years to 65 Years   (Adult, Older Adult)
  • Outcome measures - Incidence of subjects with COVID-19|Severity of COVID-19|Seroconversion to SARS-CoV-2|Subjects with symptoms|Hospital admission due to COVID-19|Admission to an intensive care unit due to COVID-19|Elapsed time until hospitalization|Elapsed time until admission into an care unit for COVID-19|Elapsed time until death not related to COVID-19
NCT04841759 The Effects of a Multi-factorial Rehabilitation Program for Healthcare Workers Suffering From Post-COVID-19 Fatigue Syndrome Completed Not Applicable Apr/01/2021 Dec/22/2021
  • Alternative id - 1181/2021
  • Interventions - Other: Exercise
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Medical University of Vienna, Vienna, Austria
  • Study designs - Allocation: Non-Randomized|Intervention Model: Parallel Assignment|Masking: Single (Participant)|Primary Purpose: Supportive Care
  • Enrollment - 46
  • Age - 18 Years to 65 Years   (Adult, Older Adult)
  • Outcome measures - Change of maximum oxygen uptake (VO2max) over time-points (baseline - 4 weeks - 8 weeks) assessed during cardio-pulmonary exercise testing (CPET)|Change of walking distance during a six minutes walk test (6MWT) over time-points (baseline - 4 weeks - 8 weeks)|Change of numbers over time-points (baseline - 4 weeks - 8 weeks) how often someone can stand up and sit down on a chair within 30 seconds during a 30-seconds sit-to-stand test (30secSTS)|Change of absolute body fat over time-points (baseline - 4 weeks - 8 weeks) via Bioelectrical Impedance Analysis (BiA)|Change of body fat percentage over time-points (baseline - 4 weeks - 8 weeks) via Bioelectrical Impedance Analysis (BiA)|Change of absolute Lean Body Mass (LBM) over time-points (baseline - 4 weeks - 8 weeks) via Bioelectrical Impedance Analysis (BiA)|Change of realtive Lean Body Mass (LBM) over time-points (baseline - 4 weeks - 8 weeks) via Bioelectrical Impedance Analysis (BiA)|Change of generalized anxiety measured over time-points (baseline - 4 weeks - 8 weeks) via Generalized Anxiety Disorder Scale-7 (GAD-7)|Change of depression measured over time-points (baseline - 4 weeks - 8 weeks) via the Patient Health Questionnaire-9 (PHQ-9)|Change of mental stress measured over time-points (baseline - 4 weeks - 8 weeks) via Perceived Stress Scale (PSS-10)|Change of fatigue measured over time-points (baseline - 4 weeks - 8 weeks) via Brief Fatigue Inventory (BFI)|Change of resilience measured over time-points (baseline - 4 weeks - 8 weeks) via Brief Resilience Scale (BRS)|Change and time kinetics of handgrip strength (HGS) over time-points (baseline and before each exercise session) measured via handgrip Dynamometer.|Change and time kinetics of physical and functional limitations of COVID-19 survivors over time-points (baseline and before each exercise session) via Post-Covid-19-Functional Scale (PCFS)|Change of work ability over time-points (baseline, 4 weeks, 8 weeks) via Work Ability Index (WAI) questionnaire.|Change of troponin (TnT) over time-points (baseline - 4 weeks - 8 weeks) via blood sample.|Change of BNP over time-points (baseline - 4 weeks - 8 weeks) via blood sample.|Change of CK-MB over time-points (baseline - 4 weeks - 8 weeks) via blood sample.|Change of HS-CRP over time-points (baseline - 4 weeks - 8 weeks) via blood sample.|Change of IL-6 over time-points (baseline - 4 weeks - 8 weeks) via blood sample.|Change of cholesterol over time-points (baseline - 4 weeks - 8 weeks) via blood sample.|Change of triglycerides over time-points (baseline - 4 weeks - 8 weeks) via blood sample.|Change of distance walked in meters per day over time|Change of time of physical activity per day in minutes over time|Change of step count per day over time|Change of average heart rate per day over time|Change of maximum heart rate per day over time|Change of average oxygen saturation (in %) per day over time|Change of Mild Cognitive Impairment over time-points (baseline, 8 weeks) via Montreal Cognitive Assessment (MoCA)|Change of sleep quality over time points (baseline, 4 weeks, 8 weeks) via Insomnia Severity Index (ISI)
NCT04405271 TAF/FTC for Pre-exposure Prophylaxis of COVID-19 in Healthcare Workers (CoviPrep Study) Not yet recruiting Phase 3 Jul/31/2020 Nov/15/2020
  • Alternative id - 5616
  • Interventions - Drug: Emtricitabine/Tenofovir Alafenamide 200 MG-25 MG Oral Tablet|Drug: Placebo
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Sociedad Argentina de Infectología, A. J. Carranza 974, Ciudad Autonoma de Buenos Aires, Capital Federal, Argentina
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)|Primary Purpose: Prevention
  • Enrollment - 1378
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - COVID-19 incident cases|Number of asymptomatic SARS-CoV-2 (Covid-19) infections confirmed by serology|Severity of symptomatic COVID-19|Respiratory symptom duration in days|Relation between treatments and symptoms duration|Time course of specific IgM/IgG seroconversion
NCT04682197 Cereset Research In Healthcare Workers During COVID-19 Recruiting Not Applicable Dec/14/2021 Nov/01/2023
  • Alternative id - IRB00066997
  • Interventions - Device: Cereset Research
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Wake Forest Baptist Health, Winston-Salem, North Carolina, United States
  • Study designs - Allocation: Randomized|Intervention Model: Single Group Assignment|Masking: None (Open Label)|Primary Purpose: Supportive Care
  • Enrollment - 138
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Change in Perceived Stress Scale (PSS)|Change in Insomnia Severity Index (ISI)|Change in Generalized Anxiety Disorder-7 (GAD-7)
NCT04903184 Exploratory Study to Evaluate the Efficacy of RUTI® Against SARS-COV-2 Infection (COVID-19) in Healthcare Workers Recruiting Phase 2 Dec/09/2020 Jan/01/2022
  • Alternative id - RUTICOVID19-ARG
  • Interventions - Biological: RUTI® vaccine|Biological: Placebo
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Hospital General de Agudos Dr. Ignacio Pirovano, Buenos Aires, Argentina|Hospital Italiano de Buenos Aires, Buenos Aires, Argentina|Hospital General, Mendoza, Argentina|Hospital José Néstor Lencinas, Mendoza, Argentina|Hospital Materno Infantil "Dr. Héctor Quintana", San Salvador De Jujuy, Argentina|Hospital de Clínicas Presidente Dr. Nicolás Avellaneda, Tucumán, Argentina
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)|Primary Purpose: Prevention
  • Enrollment - 369
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Documented cumulative incidence of SARS-CoV-2 infection|Sick leave for SARS-CoV-2|Days off work due to the quarantine|Quarantine imposed by close contact outside the center with SARS-CoV-2 positive|Fever|Incidence of self-reported acute respiratory symptoms|Days of self-reported acute respiratory symptoms|Incidence of pneumonia|Incidence of death from SARS-CoV-2 infection|Incidence of admissions to Intensive Care Unit (ICU)|Days in ICU|Incidence of mechanical ventilation|Incidence of hospital admissions|Days of hospitalization|Incidence of SARS-CoV-2 antibodies|Types of antibodies detected|Levels of SARS-CoV-2 antibodies
NCT05248217 Burnout, Covid 19, Smarthphone Addiction Completed Not Applicable Feb/25/2021 Oct/27/2021
  • Alternative id - burnout smarthphone1
  • Interventions - Behavioral: healthcare workers
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Recep Tayyip Erdogan University, Rize, None Selected, Turkey
  • Study designs - Allocation: N/A|Intervention Model: Single Group Assignment|Masking: None (Open Label)|Primary Purpose: Health Services Research
  • Enrollment - 183
  • Age - Child, Adult, Older Adult
  • Outcome measures - maslach burnout scale|smarthphone addiction scale
NCT05248412 The Long-term Spill-over Impact of COVID-19 on Health and Healthcare of People With Non-communicable Diseases Recruiting Jun/21/2021 Jun/30/2026
  • Alternative id - UW21-297
  • Interventions - Other: COVID-19 outbreaks
  • Study type - Observational
  • Study results - No Results Available
  • Locations - Department of Family Medicine & Primary Care, LKS Faculty of Medicine, University of Hong Kong, Hong Kong, Hong Kong, China
  • Study designs - Observational Model: Cohort|Time Perspective: Retrospective
  • Enrollment - 250000
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Health outcomes|Healthcare service utilization
NCT04681365 Evaluating Bubble-PAPR for Healthcare Workers Completed Feb/24/2021 Dec/31/2021
  • Alternative id - B00991
  • Interventions - Other: Staff will wear and evaluate Bubble-PAPR (non-CE marked PAPR)
  • Study type - Observational
  • Study results - No Results Available
  • Locations - Manchester University NHS Foundation Trust, Manchester, United Kingdom
  • Study designs - Observational Model: Cohort|Time Perspective: Prospective
  • Enrollment - 106
  • Age - 18 Years to 70 Years   (Adult, Older Adult)
  • Outcome measures - The primary endpoint is that participating staff rate Bubble PAPR to be more comfortable than current PPE.|Staff rate Bubble PAPR as safer than current PPE|Staff rate Bubble PAPR as easier to communicate with colleagues than existing PPE|Staff rate Bubble PAPR as easier to communicate with patients than existing PPE
NCT04363450 Hydroxychloroquine as Prophylaxis for COVID-19 in Healthcare Workers (HCQPreP) Recruiting Phase 3 Apr/27/2020 Jun/01/2021
  • Alternative id - LSU NO HSC IRB 20-050
  • Interventions - Drug: Hydroxychloroquine|Drug: Placebo
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Lafayette General Medical Center, Lafayette, Louisiana, United States|University Hospital and Clinics, Lafayette, Louisiana, United States
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)|Primary Purpose: Prevention
  • Enrollment - 1700
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Incidence of symptomatic COVID-19 infection in healthcare workers|Absenteeism from work due to COVID-19|Severity of COVID-19 infection
NCT04531774 RECHARGE: A Brief Psychological Intervention to Build Resilience in Healthcare Workers During COVID-19 Recruiting Not Applicable Aug/28/2020 Jun/01/2021
  • Alternative id - BASEC-Nr.2020-00796
  • Interventions - Behavioral: RECHARGE|Behavioral: Self Study
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Klinik für Konsiliarpsychiatrie und Psychosomatik, Zürich, Switzerland
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: None (Open Label)|Primary Purpose: Prevention
  • Enrollment - 160
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Change from Baseline in psychological distress Kessler Psychological Distress Scale (K10) at Week 5 and Week 13|Fewer worries in intervention group than in active control group|Less anxiety symptoms in intervention group than in active control group|Fewer depression symptoms in intervention group than in active control group|Lower level of burnout in intervention group than in active control group|Less traumatic stress in intervention group than in active control group|Lower level of distress due to perceived moral injury in intervention group than in active control group|Higher work performance in intervention group than in active control group
NCT04334148 Healthcare Worker Exposure Response and Outcomes of Hydroxychloroquine Completed Phase 3 Apr/22/2020 Jan/09/2021
  • Alternative id - Pro00105274
  • Interventions - Drug: Hydroxychloroquine|Drug: Placebo oral tablet
  • Study type - Interventional
  • Study results - Has Results
  • Locations - Children's Hospital Colorado/University of Colorado Denver, Aurora, Colorado, United States|University of Florida, Gainesville, Florida, United States|University of Florida Jacksonville, Jacksonville, Florida, United States|University of Florida Health Central Florida, Leesburg, Florida, United States|University of Miami Florida, Miami, Florida, United States|Advent Health, Orlando, Florida, United States|University of South Florida, Tampa, Florida, United States|Northwestern Medicine, Chicago, Illinois, United States|Rush University, Chicago, Illinois, United States|University of Iowa, Iowa City, Iowa, United States|University of Kansas Medical Center, Kansas City, Kansas, United States|University Medical Center New Orleans, New Orleans, Louisiana, United States|Ochsner Clinic Foundation, New Orleans, Louisiana, United States|Johns Hopkins, Baltimore, Maryland, United States|University of Michigan, Ann Arbor, Michigan, United States|Allina Health, Minneapolis, Minnesota, United States|Mayo Clinic Hospital Rochester, Rochester, Minnesota, United States|University of Missouri-Columbia, Columbia, Missouri, United States|University of Nebraska Medical Center, Omaha, Nebraska, United States|Hospital for Special Surgery, New York, New York, United States|Columbia University, Irving Medical Center, New York, New York, United States|Weill Cornell Medicine, New York, New York, United States|University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States|Duke University Medical Center, Durham, North Carolina, United States|Wake Forest Baptist Health Sciences, Winston-Salem, North Carolina, United States|The Ohio State University Wexner Medical Center, Columbus, Ohio, United States|Temple University Hospital, Philadelphia, Pennsylvania, United States|University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States|Clinical Trials Center of Middle Tennessee, Franklin, Tennessee, United States|Vanderbilt University Medical Center, Nashville, Tennessee, United States|University of Texas Southwestern Medical Center, Dallas, Texas, United States|Baylor Scott & White Medical Center-Temple, Temple, Texas, United States|Seattle Children's Hospital, Seattle, Washington, United States|Marshfield Clinic Health System, Marshfield, Wisconsin, United States
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Triple (Participant, Care Provider, Investigator)|Primary Purpose: Prevention
  • Enrollment - 1360
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Number of Participants With Clinical Infection With COVID-19 Infection|Number of Participants With COVID-19 Viral Shedding|Number of Participants With Serious Adverse Events (SAEs) or Hydroxychloroquine-Associated Events of Special Interest (EOSIs)
NCT04348214 Screening & Risk Assessment of Healthcare Workers & Infection Control in University & COVID-19 Quarantine Hospitals Completed Apr/22/2020 Dec/01/2020
  • Alternative id - FMASU P18a/ 2020
  • Interventions -
  • Study type - Observational
  • Study results - No Results Available
  • Locations - Faculty of Medicine Ain Shams University Research Institute- Clinical Research Center, Cairo, Non-US, Egypt
  • Study designs - Observational Model: Cohort|Time Perspective: Prospective
  • Enrollment - 4040
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Risk categorization of healthcare workers|COVID-19 infection rate among health care workers|Risk factors for COVID-19 among health care workers|Adherence of health care workers to infection prevention|Validity of the available rapid serological test for detecting COVID-19 virus infection|Clinical spectrum of COVID-19|Effectiveness of infection prevention in the health care facility|Emergency infection prevention and control needs|Isolation rate and emergency health care worker replacement needs|Rate of seroconversion
NCT04626076 International Registry of Healthcare Workers Exposed to COVID-19 Patients Recruiting Aug/13/2020 Oct/31/2021
  • Alternative id - CER-HCW-001
  • Interventions - Other: Comparative Observational Cohort Study
  • Study type - Observational
  • Study results - No Results Available
  • Locations - Aga Khan University, Karachi, Pakistan
  • Study designs - Observational Model: Other|Time Perspective: Prospective
  • Enrollment - 10000
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Occurrence of SARS-CoV-2 infection among HCWs caring for COVID-19 patients, in terms of time, geography, healthcare setting, type of HCW.|Occurrence of SARS-CoV-2 uninfected HCWs|Occurrence of SARS-CoV-2 infection with ambulatory status and no limitation of activities|Occurrence of SARS-CoV-2 infection with ambulatory status and limitation of activities|Occurrence of hospitalization due to COVID-19 illness with mild disease|Occurrence of hospitalization due to COVID-19 illness with severe disease|Occurrence of all-cause mortality|Type of prophylactic treatments by dose, frequency and duration, overall and by country/region/site
NCT04834739 Comparison of Functional Capacities of Healthcare Workers With and Without Covid-19 Completed Not Applicable Jan/04/2021 Apr/30/2021
  • Alternative id - 208
  • Interventions - Other: 6 minute walk test|Other: 1 minute Sit to Stand Test|Other: Fatigue Severity Scale|Other: Medical Research Council (MRC) dyspnea scale|Other: SF-12|Other: Beck Depression Inventory|Other: Beck Anxiety Inventory|Other: 5 times sit to stand test|Other: 6 point Likert Scale
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Gaziosmanpasa Training and Research Hospital, Istanbul, Turkey
  • Study designs - Allocation: Non-Randomized|Intervention Model: Parallel Assignment|Masking: Single (Outcomes Assessor)|Primary Purpose: Health Services Research
  • Enrollment - 60
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - 1 minute sit to stand test|5 times sit to stand test|6 minute walk test|Medical Research Council (MRC) dyspnea scale|6 point Likert Scale|Fatigue Severity Scale|Beck Depression Inventory|Beck Anxiety Scale|Short form 12
NCT04370821 COVID-19 CHAMPS Study of Healthcare, First Responder and Service Workers Active, not recruiting May/09/2020 Jun/05/2024
  • Alternative id - IRB FY2020-215
  • Interventions -
  • Study type - Observational
  • Study results - No Results Available
  • Locations - Villanova University, Villanova, Pennsylvania, United States
  • Study designs - Observational Model: Cohort|Time Perspective: Prospective
  • Enrollment - 2600
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Sample Size of enrolled CHAMPS Study participants by demographic characteristics during the first two years of the study|Exposure to SARS-CoV-2 based on models computed from participant baseline data and community variables, if available.|Infectious disease and chronic disease incidence rates by demographic characteristics|Completeness of data by demographic characteristics.|Participation rates in ancillary and sub-studies within the CHAMPS registry.|Number of participants enrolled in randomized trials based on the CHAMPS registry
NCT05120869 Healthcare Provider Human Papillomavirus Education and Professional Skills Intervention Not yet recruiting Not Applicable Feb/01/2022 Dec/01/2022
  • Alternative id - 8321|2U54MD007592-26
  • Interventions - Behavioral: Tailored HPV Education and Professional Skills Intervention Group|Behavioral: General HPV Education and Communication Skills Control Group
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Burrell College of Osteopathic Medicine, Las Cruces, New Mexico, United States|The University of Texas at El Paso, Border Biomedical Research Center, El Paso, Texas, United States
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Double (Participant, Outcomes Assessor)|Primary Purpose: Other
  • Enrollment - 150
  • Age - 18 Years to 65 Years   (Adult, Older Adult)
  • Outcome measures - Between-group changes in proportions from baseline scores on the Healthcare Provider (HCP) Practices scale and post-intervention scores of the Healthcare Personnel Survey|Between-group changes in proportions from baseline scores on the Human Papillomavirus (HPV) Vaccine Attitudes scale and post-intervention scores of the Healthcare Personnel Survey|Between-group changes in proportions from baseline scores on the Human Papillomavirus (HPV) Knowledge scale and post-intervention scores of the Healthcare Personnel Survey|Between-group changes in proportions from baseline scores on the Healthcare Provider (HCP) Communication scale and post-intervention scores on the Provider Educational/Skills Activity Assessment of the Healthcare Personnel Survey|Between-group changes in proportions from baseline scores on the Self-practice Human Papillomavirus (HPV) vaccine/screening and Intentions scale and post-intervention scores of the Healthcare Personnel Survey|Between-group differences of Personal/Family Human Papillomavirus (HPV) Attitudes scale of the Healthcare Personnel Survey
NCT04350450 Hydroxychloroquine Treatment of Healthcare Workers With COVID19 Illness at Montefiore Withdrawn Phase 2 Apr/01/2020 Aug/01/2020
  • Alternative id - 2020-11445
  • Interventions - Drug: Hydroxychloroquine
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Montefiore Medical Center, Bronx, New York, United States
  • Study designs - Allocation: Non-Randomized|Intervention Model: Parallel Assignment|Masking: None (Open Label)|Primary Purpose: Treatment
  • Enrollment - 0
  • Age - 18 Years to 99 Years   (Adult, Older Adult)
  • Outcome measures - Time to resolution of symptoms|Number of days from onset of illness to symptom resolution|Number of days to return to work|Rate of hospital admission in treated and untreated healthcare workers|Adverse effect of HCQ during treatment
NCT04626050 General Psychological Distress, PTSD, and Co-Morbidities in Healthcare Workers Consequent to COVID-19 Recruiting Not Applicable Jan/20/2022 Jul/01/2022
  • Alternative id - 20-04021913
  • Interventions - Behavioral: Medical Music|Behavioral: Narrative Writing|Behavioral: Prolonged Exposure Therapy|Behavioral: Interpersonal Psychotherapy
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Weill Cornell Medicine, New York, New York, United States
  • Study designs - Allocation: Randomized|Intervention Model: Sequential Assignment|Masking: Single (Outcomes Assessor)|Primary Purpose: Treatment
  • Enrollment - 120
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Feasibility Indicator: Recruitment (Phase I)|Feasibility Indicator: Recruitment (Phase II)|Feasibility Indicator: Enrollment (Phase I)|Feasibility Indicator: Enrollment (Phase II)|Feasibility Indicator: Retention (Phase I)|Feasibility Indicator: Retention (Phase II)|Acceptability Indicator: Satisfaction (Phase I)|Acceptability Indicator: Satisfaction (Phase II)|Preliminary Efficacy as Measured by Change in Clinician-Administered PTSD Scale Score (Phase I)|Preliminary Efficacy as Measured by Change in Clinician-Administered PTSD Scale Score (Phase II)|Change in Anxiety Symptoms measured by the Generalized Anxiety Disorder 7-Item Scale (Phase I)|Change in Anxiety Symptoms measured by the Generalized Anxiety Disorder 7-Item Scale (Phase II)|Change in Depressive Symptoms measured by the Beck Depression Inventory-II (Phase I)|Change in Depressive Symptoms measured by the Beck Depression Inventory-II (Phase II)|Change in score on the Pittsburgh Sleep Quality Index (PSQI) (Phase I)|Change in score on the Pittsburgh Sleep Quality Index (PSQI) (Phase II)|Change in score on the Moral Distress Scale (Phase I)|Change in score on the Moral Distress Scale (Phase II)|Change in score on the Modified Moral Injury Events Scale (Phase I)|Change in score on the Modified Moral Injury Events Scale (Phase II)|Change in score on the PTSD Checklist for DSM-5 (PCL-5) (Phase I)|Change in score on the PTSD Checklist for DSM-5 (PCL-5) (Phase II)|Change in score on the Sheehan Disability Scale (SDS) (Phase I)|Change in score on the Sheehan Disability Scale (SDS) (Phase II)|Change in score on the World Health Organization Quality of Life Scale - Brief (Phase I)|Change in score on the World Health Organization Quality of Life Scale - Brief (Phase II)|Change in score on the Social Adjustment Scale (SAS) (Phase I)|Change in score on the Social Adjustment Scale (SAS) (Phase II)|Change in Score on the Occupational Stress Inventory Revised (OSI-R) (Phase I)|Change in Score on the Occupational Stress Inventory Revised (OSI-R) (Phase II)|Change in Score on the Multidimensional Scale of Perceived Social Support (MSPSS) (Phase I)|Change in Score on the Multidimensional Scale of Perceived Social Support (MSPSS) (Phase II)|Change in score on the Posttraumatic Cognitions Inventory (Phase I)|Change in score on the Posttraumatic Cognitions Inventory (Phase II)|Change in score on the Difficulties in Emotion Regulation Scale (DERS) (Phase I)|Change in score on the Difficulties in Emotion Regulation Scale (Phase II)
NCT04371523 Hydroxychloroquine to Prevent COVID-19 Disease Amongst Healthcare Workers Withdrawn Phase 3 May/01/2020 Aug/30/2020
  • Alternative id - 3190
  • Interventions - Drug: Apo-Hydroxychloroquine|Drug: Matched Placebo
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - St. Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)|Primary Purpose: Prevention
  • Enrollment - 0
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Positive for SARS-CoV-2|Hospital admissions|Intensive care unit admissions|Intubation and mechanical ventilation|ICU length of stay|Hospital length of stay|Mortality|Incidence of adverse events
NCT04370015 Hydroxychloroquine Chemoprophylaxis for COVID-19 Infection in High-risk Healthcare Workers. Not yet recruiting Not Applicable May/15/2020 Oct/15/2020
  • Alternative id - 16082019
  • Interventions - Drug: Hydroxychloroquine|Drug: Placebo oral tablet
  • Study type - Interventional
  • Study results - No Results Available
  • Locations -
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)|Primary Purpose: Prevention
  • Enrollment - 374
  • Age - 18 Years to 60 Years   (Adult)
  • Outcome measures - Prevention of SARS-CoV-2 as determined by negative RT-PCR at the end of 12 week study period|Safety as determined by presence or absence of any adverse event related with hydroxychloroquine treatment|Confirmed SARS-CoV-2 infection based on symptoms and confirmed by RT-PCR|Clinical disease severity in confirmed SARS-CoV-2 participants|Incidence of any acute respiratory infection
NCT04918160 Evaluation of the Sanitary Safety of a Healthcare Professional Conference Held 9-11 June 2021 in Paris Completed Jun/08/2021 Jul/02/2021
  • Alternative id - 2021-A01185-36
  • Interventions - Other: Exposure to the FICS annual meeting (June 9-11 2021, Paris Congress Center)
  • Study type - Observational
  • Study results - No Results Available
  • Locations - Centre des Congres, Paris, France
  • Study designs - Observational Model: Case-Control|Time Perspective: Prospective
  • Enrollment - 711
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Conference attendees COVID-19 prevalence at D7|Controls COVID-19 prevalence at D7|Proportion of conference attendees with COVID-19 symptoms at D21|Proportion of conference attendees with COVID-19-related medical consultation at D21|Proportion of conference attendees with COVID-19-related emergency department visit at D21|Proportion of conference attendees with COVID-19-related hospitalisation at D21
NCT04728958 Reflective Tasks With Healthcare Workers During COVID-19 Not yet recruiting Not Applicable Jul/01/2021 Sep/01/2022
  • Alternative id - 170732
  • Interventions - Behavioral: Gratitude
  • Study type - Interventional
  • Study results - No Results Available
  • Locations -
  • Study designs - Allocation: Randomized|Intervention Model: Factorial Assignment|Masking: Single (Participant)|Primary Purpose: Treatment
  • Enrollment - 219
  • Age - 18 Years to 65 Years   (Adult, Older Adult)
  • Outcome measures - Change in Anxiety Level|Change in Depression Level|Change in Stress Level|Change in Subjective Happiness Level|Change in Satisfaction with Life|Change in State Gratitude|State Gratitude Score|Change in Trait Gratitude|Trait Gratitude score
NCT05185232 Congenital Heart Initiative-Redefining Outcomes and Navigation to Adult Centered Care Not yet recruiting Apr/01/2022 Jun/30/2024
  • Alternative id - Pro00016403
  • Interventions - Other: Impact of gaps in care/loss to healthcare follow-up
  • Study type - Observational
  • Study results - No Results Available
  • Locations - University of California, San Francisco, California, United States|Children's Hospital Colorado, Aurora, Colorado, United States|Children's National Hospital, Washington, District of Columbia, United States|University of Miami, Coral Gables, Florida, United States|University of Florida, Gainesville, Florida, United States|Nicklaus Children's Hospital, Miami, Florida, United States|Louisiana Public Health Institute, New Orleans, Louisiana, United States|Ochsner, New Orleans, Louisiana, United States|Mount Sinai, New York, New York, United States|NYU Langone Health, New York, New York, United States|Columbia Presbyterian, New York, New York, United States|Weill Cornell Medicine, New York, New York, United States|Duke Coordinating Center, Durham, North Carolina, United States|Cincinnati Children's Hospital, Cincinnati, Ohio, United States|Nationwide Children's, Columbus, Ohio, United States|Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States
  • Study designs - Observational Model: Cohort|Time Perspective: Prospective
  • Enrollment - 3000
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Rates of healthcare use|Rates of comorbidities|Number of Participants with gaps in care
NCT05279443 Effect of Yoga-based Exercises of Healthcare Workers During COVID-19 Pandemic: Prospective Clinical Trial Completed Not Applicable Mar/10/2021 Sep/10/2021
  • Alternative id - Refiye000000000000000000000001
  • Interventions - Other: yoga-based exercises therapy
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Ankara City Hospital Physical Therapy and Rehabilitation Hospital, Ankara, Turkey
  • Study designs - Allocation: N/A|Intervention Model: Single Group Assignment|Masking: None (Open Label)|Primary Purpose: Treatment
  • Enrollment - 26
  • Age - 23 Years to 55 Years   (Adult)
  • Outcome measures - Six minute walk test|modified Medical Research Council (mMRC) dyspnoea scale|Beck Anxiety Inventory
NCT04422418 Impact of Burnout on Cardiovascular and Immune Biomarkers in Healthcare Professionals - Covid-19 Pandemic in Abu Dhabi Recruiting Jul/01/2020 Dec/31/2020
  • Alternative id - CPRA-2020-034
  • Interventions -
  • Study type - Observational
  • Study results - No Results Available
  • Locations - Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates|Mediclinic, Abu Dhabi, United Arab Emirates|Sheikh Khalifa Medical City, Abu Dhabi, United Arab Emirates|Sheikh Shakhbout Medical City, Abu Dhabi, United Arab Emirates
  • Study designs - Observational Model: Cohort|Time Perspective: Prospective
  • Enrollment - 200
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Change from Baseline Burnout at 2-3 months and 6 months|Change from Baseline Cardiovascular Risk Cardiovascular Risk Through Heart Rate Variability Markers at 2-3 months and 6 months|Change from Baseline Through Actigraphy at 2-3 months and 6 months|Change from Baseline Through Sleep Quality at 2-3 months and 6 months|Change from Baseline Cardiovascular Risk Through Fuster-BEWAT score at 2-3 months and 6 months|Change from Baseline Immune Dysfunction at 2-3 months and 6 months|Change from Baseline Cardio-Respiratory Fitness at 2-3 months and 6 months
NCT04705753 Assessment of the Clinical Effectiveness of a Herbal Extract (Cretan IAMA) in Patients With Viral Respiratory Infections, Including COVID-19, in Primary Healthcare Settings, and Co-assessment of Its Prophylactic Effect in People Cohabiting With These Patients Completed Phase 2|Phase 3 Apr/01/2020 Oct/15/2020
  • Alternative id - 78/26.03.2020
  • Interventions - Dietary Supplement: Cretan IAMA
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Cretan Medicare, Heraklion, Crete, Greece
  • Study designs - Allocation: N/A|Intervention Model: Single Group Assignment|Masking: None (Open Label)|Primary Purpose: Treatment
  • Enrollment - 20
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Number of patients with symptom resolution|Number of people cohabiting with a patient not developing VRI symptoms|Median time to full symptom resolution|Intensity of symptoms|Duration of symptoms|Number of patients whose symptoms never exceeded a score of 3-4 (mild)|Quality of life (QoL) of patients
NCT04303507 Chloroquine/ Hydroxychloroquine Prevention of Coronavirus Disease (COVID-19) in the Healthcare Setting Active, not recruiting Not Applicable Apr/29/2020 Mar/21/2022
  • Alternative id - VIR20001
  • Interventions - Drug: Chloroquine or Hydroxychloroquine|Drug: Placebo
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Centre Hospitalier et Universitaire de Zone Abomey-Calavi, Abomey-Calavi, Benin|Hospital De Zone Allada, Allada, Benin|University Hospital Center of Angre, Abidjan, Côte D'Ivoire|University Hospital Center of Bouake, Bouake, Côte D'Ivoire|Airlangga University Hospital (UNAIR), Surabaya, East Java, Indonesia|Husada Utama Hospital, Surabaya, East Java, Indonesia|Bunda Thamrin Hospital, Medan, North Sumatra, Indonesia|Murni Teguh Memorial Hospital, Medan, North Sumatra, Indonesia|Sardjito Hospital, Yogyakarta, Indonesia|Fountain Healthcare Hospital, Eldoret, Kenya|Mbagathi County Hospital, Nairobi, Kenya|The Bamako Hospital of Dermatology, Bamako, Mali|Hospital Of Mali, Bamako, Mali|B.P. Koirala Institute of Health Sciences, Dharān Bāzār, Nepal|The Aga Khan University Hospital, Karachi, Pakistan|Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand|University Hospitals Of Morecambe Bay NHS Foundation Trust, Kendal, Cumbria, United Kingdom|The Dudley Group NHS Foundation Trust, Dudley, West Midlands, United Kingdom|Birmingham & Solihull Mental Health NHS Trust, Birmingham, United Kingdom|Brighton and Sussex University Hospitals NHS Trust, Brighton, United Kingdom|University Hospitals Coventry and Warwickshire NHS Trust, Coventry, United Kingdom|Rotherham, Doncaster And South Humber NHS Foundation Trust, Doncaster, United Kingdom|Imperial College Healthcare NHS Trust, London, United Kingdom|Oxford University Hospital NHS Foundation Trust, Oxford, United Kingdom|Zambart, Lusaka, Zambia
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Double (Participant, Investigator)|Primary Purpose: Prevention
  • Enrollment - 40000
  • Age - 16 Years and older   (Child, Adult, Older Adult)
  • Outcome measures - Number of symptomatic COVID-19 infections|Symptoms severity of COVID-19|Number of asymptomatic cases of COVID-19|Number of symptomatic acute respiratory illnesses|Severity of symptomatic acute respiratory illnesses
NCT04461379 Prevention, Efficacy and Safety of BCG Vaccine in COVID-19 Among Healthcare Workers Active, not recruiting Phase 3 Jul/21/2020 Jan/01/2021
  • Alternative id - EN20-00011
  • Interventions - Biological: BCG vaccine|Other: Placebo
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Hospital Universitario "José E. González", Monterrey, Nuevo León, Mexico
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Triple (Participant, Care Provider, Outcomes Assessor)|Primary Purpose: Prevention
  • Enrollment - 908
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Demonstrate COVID- 19 disease incidence among Health care workers:|Demonstrate cumulative incidence of hospitalization for COVID-19 among Health care workers:|Demonstrate the Incidence of specific Antibodies against SARS-CoV-2 at 3 and 6 months in health care workers|Hospitalization of severe disease COVID-19|Oxygen supplementation in severe disease COVID-19|Need for intubation or non-invasive ventilation for the patient.|Critical care admission with SARS-CoV2|Mortality associated to progressive pulmonary disease|Evaluate the safety of the vaccine by measuring the incidence rates of local and systemic adverse effects that occur after one month its application.|Calculate the incidence of COVID-19 complications|Determine the mean days of hospitalization and days in intensive care unit by COIVD-19|Calculate the cost associated with in-hospital medical care|Determine the scores of the Clinical Prediction Rules associated with mortality using Sequential Organ Failure Assessment (SOFA score) at the patient's hospital admission:|Determine the scores of the Clinical Prediction Rules associated with mortality using Acute Physiology and Chronic Health disease Classification System (APACHE) at the patient's hospital admission:|Evaluate and determine the alteration profile in laboratory studies at the patient's hospital admission|Registration of chronic medications|Need for vasopressors
NCT04648800 Clinical Trial Evaluating the Effect of BCG Vaccination on the Incidence and Severity of SARS-CoV-2 Infections Among Healthcare Professionals During the COVID-19 Pandemic in Poland Recruiting Phase 3 Jul/07/2020 Apr/01/2021
  • Alternative id - BCG/COVID-19/UR/04/2020|2020-002111-22
  • Interventions - Drug: BCG-10 vaccine|Drug: 0.9% saline
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Department of Anesthesiology and Intensive Care, University Clinical Center, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland|Stefan Żeromski Specialist Hospital, Kraków, Poland|Voivodeship Hospital nr 2 in the Name of The Saint Queen Jadwiga, University of Rzeszów, Poland, Rzeszów, Poland|Saint Jadwiga Śląska Hospital, Trzebnica, Poland|Department of Pediatrics, Bielanski Hospital,, Warsaw, Poland|Praski Hospital, Warsaw, Poland
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Triple (Participant, Investigator, Outcomes Assessor)|Primary Purpose: Prevention
  • Enrollment - 1000
  • Age - 25 Years and older   (Adult, Older Adult)
  • Outcome measures - death and life- or health-threatening condition (cardiac arrest with effective resuscitation, shock, severe respiratory failure, severe renal failure, stroke/transient cerebral ischaemia)|Onset of clinical symptoms of COVID-19|asymptomatic SARS-CovV-2 infection|Hospitalisation|ICU Hospitalisation|Dyspnoea
NCT04870307 Community-engaged Approaches to Testing in Community and Healthcare Settings for Underserved Populations Recruiting Not Applicable Sep/30/2020 Sep/01/2023
  • Alternative id - 12582|U54GM104938-08S1
  • Interventions - Other: Dissemination and Implementation Research
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Oklahoma Clinical and Translational Science Institute, Oklahoma City, Oklahoma, United States
  • Study designs - Allocation: N/A|Intervention Model: Single Group Assignment|Masking: None (Open Label)|Primary Purpose: Other
  • Enrollment - 780
  • Age - Child, Adult, Older Adult
  • Outcome measures - Change in SARS-CoV-2 Testing Rate (Practices)|Change in SARS-CoV-2 Test Positivity Rate (Community Sites)|Barriers to SARS-CoV-2 Testing (Practices)|Change in Influenza Vaccination Rate (NQF #41)|Change in Pneumococcal Vaccination Rate (NQF #127)|Change in Zoster Vaccination Rate|COVID-19 Referrals
NCT05246124 The Effect of Demographic, Mental, and Physical Activity Profiles Towards Burnout in Frontline Healthcare Workers Facing COVID-19 Pandemics in Dr. Soetomo General Hospital Surabaya Completed Not Applicable May/25/2020 Jun/13/2020
  • Alternative id - 0006/KEPK/V/2020
  • Interventions - Other: Zumba dance exercise
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Dr. Soetomo General Hospital, Surabaya, East Java, Indonesia
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Triple (Care Provider, Investigator, Outcomes Assessor)|Primary Purpose: Prevention
  • Enrollment - 61
  • Age - Child, Adult, Older Adult
  • Outcome measures - State-Trait Anxiety Inventory (STAI)|Brief Resiliency Scale (BRS)|Maslach Burnout Inventory (MBI)|Cortisol|CD4|Interleukin-6 (IL-6)|Neutrophil to lymphocyte ratio (NLR)
NCT04880668 Impact of Aerosol Box Use on Healthcare Provider Contamination Not yet recruiting Not Applicable Jul/01/2021 Jul/01/2023
  • Alternative id - REB20-0893
  • Interventions - Device: Aerosol Box (Splashguard)
  • Study type - Interventional
  • Study results - No Results Available
  • Locations -
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: None (Open Label)|Primary Purpose: Other
  • Enrollment - 132
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Change in Integrated Density (Pre vs Post Doffing)|Change in Area of contamination (Pre vs Post Doffing)|Time to task completion|First pass success rate|Number of healthcare providers contaminated|Number of different body parts contaminated|Environmental Contamination|Provider Workload|Quality of intubation performance|Provider opinions on aerosol box
NCT04429828 COVID-19 Psychological Wellbeing for Healthcare Students Completed Not Applicable Jun/13/2020 Dec/30/2020
  • Alternative id - PoWerS_June2020
  • Interventions - Other: COVID-19 e-package: Psychological wellbeing for healthcare workers
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - University of Nottingham, Nottingham, United Kingdom
  • Study designs - Allocation: N/A|Intervention Model: Single Group Assignment|Masking: None (Open Label)|Primary Purpose: Supportive Care
  • Enrollment - 42
  • Age - Child, Adult, Older Adult
  • Outcome measures - Qualitative Interviews with Healthcare Students|Warwick-Edinburgh Mental Wellbeing Scale|Single Item Measure of Global Job Stressfulness (Houdmont et al, 2019)|Single Item Global Job Satisfaction Measure (Dolbier et al, 2005)|Single Item Measure of Presenteeism (Aronsson & Gustafsson, 2004)|Single Item Measure of Turnover intentions|Work Engagement (Shaufeli et al, 2006)
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