Other substances

7-bromo-5-chloro-8-hydroxyquinoline

A hydroxyquinoline.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Experimental

1
 Supporting references
0
 Contradictory references
1
 AI-suggested references
0
 Clinical trials

General information

7-bromo-5-chloro-8-hydroxyquinoline is a clioquinol derivative.

7-bromo-5-chloro-8-hydroxyquinoline on PubChem

 

Structure image - 7-bromo-5-chloro-8-hydroxyquinoline

C1=CC2=C(C(=C(C=C2Cl)Br)O)N=C1

Supporting references

Link Tested on Impact factor Notes Publication date
Discovery of Clioquinol and analogues as novel inhibitors of Severe Acute Respiratory Syndrome Coronavirus 2 infection, ACE2 and ACE2 - Spike protein interaction in vitro
Spike protein ACE2 Enzyme assay In vitro 		in vitro binding assay; in vitro enzyme assay; Vero E6 cells; SARS-CoV-2 strain USA_WA1/2020

The compound inhibited SARS-CoV-2-induced cytopathic effect in Vero E6 cells with an IC50 of 14.69 μM. It was shown to block the interaction between Spike protein RBD and a recombinant form of human ACE2 receptor. It also impeded ACE2’s exopeptidase activity in vitro.

 Mar/11/2021

AI-suggested references

Link Publication date
Inhibitory mechanism of clioquinol and its derivatives at the exopeptidase site of human angiotensin-converting enzyme-2 and receptor binding domain of SARS-CoV-2 viral spike.
Oct/30/2021
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