5-(((4-nitrophenoxy)carbonyl)amino)-2-methyl-N-[(1R)-1-naphthalen-1-ylethyl]benzamide
A naphtalene derivative.
General information
5-(((4-nitrophenoxy)carbonyl)amino)-2-methyl-N-[(1R)-1-naphthalen-1-ylethyl]benzamide is an experimental SARS-CoV-2 Papain-like protease inhibitor (Osipiuk et al., 2021).
(Structure image generated in SwissSimilarity)
C[C@@H](NC(=O)C1=C(C)C=CC(NC(=O)OC2=CC=C(C=C2)n(:o):o)=C1)C1=CC=CC2=CC=CC=C12
Supporting references
Link | Tested on | Impact factor | Notes | Publication date |
---|---|---|---|---|
Structure of papain-like protease from SARS-CoV-2 and its complexes with non-covalent inhibitors
PapainLpro Small molecule Enzyme assay In vitro |
in vitro enzyme assay; Vero E6 cells; SARS-CoV-2 astrain nCoV/Washington/1/2020 | 12.12 | Inhibits SARS-CoV-2 Papain-like protease in vitro with IC50 of ca. 7 μM. |
Feb/02/2021 |