Other substances

4-[(pyridin-3-ylmethyl) amino]-2H-chromen-2-one

A 4-hydroxycoumarin derivate.

Phase of research

Potential treatment - theoretical effect

How it helps

Antiviral

Drug status

Experimental

1
 Supporting references
0
 Contradictory references
1
 AI-suggested references
37
 Clinical trials

General information

4-[(pyridin-3-ylmethyl) amino]-2H-chromen-2-one on PubChem

Synonyms

LTA

 

Structure image - 4-[(pyridin-3-ylmethyl) amino]-2H-chromen-2-one

C1=CC=C2C(=C1)C(=CC(=O)O2)NCC3=CN=CC=C3

Supporting references

Link Tested on Impact factor Notes Publication date
Crystal structure, chemical reactivity, kinetic and thermodynamic studies of new ligand derived from 4-hydroxycoumarin: Interaction with SARS-CoV-2
3CLpro Small molecule In silico 		in silico 2.46

Predicted to inhibit the SARS-CoV-2 3C-like protease.

 Jul/16/2020

AI-suggested references

Link Publication date
Novel Biomimetic Human TLR2-Derived Peptides for Potential Targeting of Lipoteichoic Acid: An In Silico Assessment.
Aug/21/2021

Clinical trials

ID Title Status Phase Start date Completion date
NCT04395872 Psychiatric Consultation for COVID-19 Patients Not yet recruiting May/28/2020 Dec/31/2020
  • Alternative id - CR-20-062
  • Interventions - Behavioral: Psychiatric counseling
  • Study type - Observational
  • Study results - No Results Available
  • Locations -
  • Study designs - Observational Model: Case-Only|Time Perspective: Retrospective
  • Enrollment - 54
  • Age - Child, Adult, Older Adult
  • Outcome measures - Change of PHQ-9 (Patient Health Questionnaire-9)|Change of GAD-7 (Patient Health Questionnaire-9)|Change of PC-PTSD-5 (Primary Care PTSD Screen for DSM-5)|Change of AIS (Athens Insomnia Scale)|Change of P4 (P4 Suicidality Screener)|Change of SF-36 (Short Form Health Survey Questionnaire)|Change of SCL-90-R
NCT04516915 IMU-838 and Oseltamivir in the Treatment of COVID-19 Recruiting Phase 2 Jun/15/2020 Jul/01/2021
  • Alternative id - RA486120
  • Interventions - Drug: IMU-838|Drug: Oseltamivir
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - University Hospital Coventry and Warwickshire NHS Trust, Coventry, West Midlands, United Kingdom
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: None (Open Label)|Primary Purpose: Treatment
  • Enrollment - 120
  • Age - 18 Years to 90 Years   (Adult, Older Adult)
  • Outcome measures - To evaluate whether time-to-improvement is significantly better in IMU-838 plus Oseltamivir (IONIC Intervention) vs. Oseltamivir alone in adult subjects with COVID-19|To evaluate safety (number of adverse events) and tolerability (laboratory abnormalities) of IMU 838 + Oseltamivir vs. Oseltamivir alone in adult subjects with COVID-19.|To determine the effects of IONIC Intervention on improvement of at least two points in clinical status scale (from 0 to 8; with 8 being no evidence of clinical infection and 8 being death)|To assess the effects of IONIC Intervention vs. Oseltamivir on the need for invasive ventilation, renal replacement therapy or ECMO|To assess the effects of IONIC Intervention vs. Oseltamivir on the length of hospital and intensive care unit (ICU) stay|To assess the effects of IONIC Intervention vs. Oseltamivir on the time from treatment initiation to death
NCT04385108 Predictive Immune Biomarkers for COVID-19 Pathogenesis Recruiting Not Applicable Mar/04/2020 Dec/31/2021
  • Alternative id - RC31/20/0162
  • Interventions - Biological: Blood collection on admission and longitudinally|Biological: Blood collection on their first consultation and 10 to 14 days later
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Purpan University Hospital, Toulouse, France
  • Study designs - Allocation: Non-Randomized|Intervention Model: Parallel Assignment|Masking: None (Open Label)|Primary Purpose: Basic Science
  • Enrollment - 400
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Immune signature|Dosage of cytokines and chemokines in plasma samples|Analysis of the early dynamics of SARS-CoV-2-specific humoral immunity
NCT04482387 DigiVis: Self-testing Vision App for Telephone Consultations Recruiting Not Applicable Jul/24/2020 Jul/01/2021
  • Alternative id - IRAS196573
  • Interventions - Device: DigiVis visual acuity app
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Cambridge University Hospitals NHS Trust, Cambridge, Cambs, United Kingdom
  • Study designs - Allocation: N/A|Intervention Model: Sequential Assignment|Masking: None (Open Label)|Primary Purpose: Diagnostic
  • Enrollment - 250
  • Age - 5 Years to 85 Years   (Child, Adult, Older Adult)
  • Outcome measures - Comparison of visual acuity measurement using DigiVis testing and standard visual acuity testing|Levels of Agreement between DigiVis testing and standard visual acuity testing|DigiVis test repeatability
NCT04341714 Efficiency and Satisfaction With Telephone Consultation in Neuro-urology: Experience of the COVID-19 Pandemic Completed Mar/16/2020 Jun/15/2020
  • Alternative id - GREEN GRC01
  • Interventions - Other: Satisfaction evaluation
  • Study type - Observational
  • Study results - No Results Available
  • Locations - Department of Neuro- Urology, Hôpital Tenon, Paris, France
  • Study designs - Observational Model: Cohort|Time Perspective: Prospective
  • Enrollment - 450
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Efficiency of the telephone consultation|Satisfaction of the telephone consultation
NCT02735707 Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia Recruiting Phase 3 Apr/11/2016 Dec/01/2025
  • Alternative id - U1111-1189-1653|2015-002340-14|602525|16/631|APP1101719|158584
  • Interventions - Drug: Ceftriaxone|Drug: Moxifloxacin or Levofloxacin|Drug: Piperacillin-tazobactam|Drug: Ceftaroline|Drug: Amoxicillin-clavulanate|Drug: Standard course macrolide|Drug: Extended course macrolide|Other: No systemic corticosteroid|Drug: Fixed-duration Hydrocortisone|Drug: Shock-dependent hydrocortisone|Drug: Fixed-duration higher dose Hydrocortisone|Other: No antiviral agent for influenza|Drug: Five-days oseltamivir|Drug: Ten-days oseltamivir|Other: No antiviral agent for COVID-19|Drug: Lopinavir / Ritonavir|Drug: Hydroxychloroquine|Drug: Hydroxychloroquine + lopinavir/ritonavir|Drug: Ivermectin|Other: No immune modulation for COVID-19|Drug: Interferon beta-1a|Drug: Anakinra|Drug: Tocilizumab|Drug: Sarilumab|Drug: Local standard venous thromboprophylaxis|Drug: Therapeutic anticoagulation|Drug: Conventional low dose thromboprophylaxis|Drug: Intermediate dose thromboprophylaxis|Drug: Continuation of therapeutic dose anticoagulation|Other: No immunoglobulin|Biological: Convalescent plasma|Biological: Delayed administration of convalescent plasma|Other: No vitamin C|Drug: Vitamin C|Other: No antiplatelet|Drug: Aspirin|Drug: P2Y12 inhibitor|Other: No simvastatin|Drug: Simvastatin|Other: Placebo|Drug: Eritoran|Drug: Apremilast|Procedure: Clinician-preferred mechanical ventilation strategy|Procedure: Protocolised mechanical ventilation strategy|Other: No renin-angiotensin system inhibitor|Drug: Angiotensin converting enzyme inhibitor|Drug: Angiotensin Receptor Blockers|Drug: ARB + DMX-200|Other: No cysteamine|Drug: Cysteamine
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - University of Florida, Jacksonville, Florida, United States|Augusta University, Augusta, Georgia, United States|University of Illinois Health, Chicago, Illinois, United States|Tulane Medical Center, New Orleans, Louisiana, United States|University of Michigan, Ann Arbor, Michigan, United States|Memorial Sloan Kettering Cancer Center, New York, New York, United States|Wake Forest Baptist Health, Winston-Salem, North Carolina, United States|The Ohio State University Wexner Medical Center, Columbus, Ohio, United States|Oregon Health and Science University, Portland, Oregon, United States|University of Pittsburgh Medical Centre, Pittsburgh, Pennsylvania, United States|Brown University - Rhode Island Hospital, Providence, Rhode Island, United States|Canberra Hospital, Canberra, Australian Capital Territory, Australia|Bankstown-Lidcombe Hospital, Bankstown, New South Wales, Australia|Blacktown Hospital, Blacktown, New South Wales, Australia|Campbelltown Hospital, Campbelltown, New South Wales, Australia|Sutherland Hospital, Caringbah, New South Wales, Australia|Concord Hospital, Concord, New South Wales, Australia|Dubbo Base Hospital, Dubbo, New South Wales, Australia|Northern Beaches Hospital, Frenchs Forest, New South Wales, Australia|Nepean Hospital, Kingswood, New South Wales, Australia|St. George Hospital, Kogarah, New South Wales, Australia|Liverpool Hospital, Liverpool, New South Wales, Australia|John Hunter Hospital, Newcastle, New South Wales, Australia|Orange Health Service, Orange, New South Wales, Australia|St Vincent's Hospital Sydney, Sydney, New South Wales, Australia|Prince of Wales Hospital, Sydney, New South Wales, Australia|Royal Prince Alfred Hospital, Sydney, New South Wales, Australia|Royal North Shore Hospital, Sydney, New South Wales, Australia|Wollongong Hospital, Sydney, New South Wales, Australia|Wagga Wagga Base Hospital, Wagga Wagga, New South Wales, Australia|Westmead Hospital, Westmead, New South Wales, Australia|Royal Darwin Hospital,, Darwin, Northern Territory, Australia|Sunshine Coast University Hospital, Birtinya, Queensland, Australia|The Prince Charles Hospital, Brisbane, Queensland, Australia|Mater Hospital Brisbane, Brisbane, Queensland, Australia|Princess Alexandra Hospital, Brisbane, Queensland, Australia|Caboolture Hospital, Caboolture, Queensland, Australia|Queen Elizabeth II Jubilee Hospital, Coopers Plains, Queensland, Australia|Logan Hospital, Logan, Queensland, Australia|Redcliffe Hospital, Redcliffe, Queensland, Australia|Rockhampton Hospital, Rockhampton, Queensland, Australia|Gold Coast University Hospital, Southport, Queensland, Australia|Toowoomba Hospital, Toowoomba, Queensland, Australia|Townsville Hospital, Townsville, Queensland, Australia|Royal Adelaide Hospital, Adelaide, South Australia, Australia|The Queen Elizabeth Hospital, Adelaide, South Australia, Australia|Lyell McEwin Hospital, Adelaide, South Australia, Australia|Flinders Medical Centre, Bedford Park, South Australia, Australia|Launceston Hospital, Launceston, Tasmania, Australia|Ballarat Base Hospital, Ballarat, Victoria, Australia|Bendigo Hospital, Bendigo, Victoria, Australia|Casey Hospital, Berwick, Victoria, Australia|Box Hill Hospital, Box Hill, Victoria, Australia|Monash Medical Centre, Clayton, Victoria, Australia|Dandenong Hospital, Dandenong, Victoria, Australia|Angliss Hospital, Ferntree Gully, Victoria, Australia|Footscray Hospital, Footscray, Victoria, Australia|University Hosptial Geelong, Geelong, Victoria, Australia|The Alfred Hospital, Melbourne, Victoria, Australia|Royal Melbourne Hospital, Melbourne, Victoria, Australia|St Vincent's Hospital Melbourne, Melbourne, Victoria, Australia|Maroondah Hospital, Ringwood East, Victoria, Australia|Sunshine Hospital, Sunshine, Victoria, Australia|Werribee Mercy Hospital, Werribee, Victoria, Australia|St John of God Hospital Midland, Midland, Western Australia, Australia|St John of God Hospital Murdoch, Murdoch, Western Australia, Australia|Royal Perth Hospital, Perth, Western Australia, Australia|Sir Charles Gairdner Hospital, Perth, Western Australia, Australia|Fiona Stanley Hospital, Perth, Western Australia, Australia|St John of God Subiaco, Subiaco, Western Australia, Australia|AZ Sint-Jan, Brugge, Belgium|CHU de Charleroi - Hôpital Civil Marie Curie, Charleroi, Belgium|Universitair Ziekenhuis Antwerp, Edegem, Belgium|Universitair Ziekenhuis Gent, Gent, Belgium|Foothills Medical Centre, Calgary, Alberta, Canada|Peter Lougheed Centre, Calgary, Alberta, Canada|Rockyview General Hospital, Calgary, Alberta, Canada|South Health Campus, Calgary, Alberta, Canada|Royal Alexandra Hospital, Alberta, Edmonton, Alberta, Canada|University of Alberta Hospital, Edmonton, Alberta, Canada|Surrey Memorial Hospital, Surrey, British Columbia, Canada|St Boniface General Hospital, Winnipeg, Manitoba, Canada|Health Sciences Centre Winnipeg, Winnipeg, Manitoba, Canada|Grace Hospital, Winnipeg, Manitoba, Canada|Dr. Everett Chalmers Regional Hospital, Fredericton, New Brunswick, Canada|The Moncton Hospital, Fredericton, New Brunswick, Canada|The Saint John General Hospital, Fredericton, New Brunswick, Canada|William Osler Health System, Brampton, Ontario, Canada|Brantford General Hospital, Brantford, Ontario, Canada|Hamilton general Hospital, Hamilton, Ontario, Canada|Juravinski Hospital, Hamilton, Ontario, Canada|St. Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada|Kingston Health Sciences Centre, Kingston, Ontario, Canada|Grand River Hospital, Kitchener, Ontario, Canada|St Mary's General Hospital, Kitchener, Ontario, Canada|The Ottawa Hospital, Ottawa, Ontario, Canada|Niagara Health, Saint Catharines, Ontario, Canada|Thunder Bay General Hospital, Thunder Bay, Ontario, Canada|Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada|St. Michael's Hospital Unity Health Toronto, Toronto, Ontario, Canada|Mount Sinai Hospital, Toronto, Ontario, Canada|Toronto General Hospital, Toronto, Ontario, Canada|Toronto Western Hospital, Toronto, Ontario, Canada|St Joseph's Health Centre, Toronto, Ontario, Canada|CIUSS Chaudieres-Appalaches (Levis), Lévis, Quebec, Canada|Hospital Maisonneuve-Rosemont, Montréal, Quebec, Canada|Hôpital Fleury, Montréal, Quebec, Canada|Centre Hospitalier de l'Universite de Montreal, Montréal, Quebec, Canada|McGill University Health Centre, Montréal, Quebec, Canada|Hopital du Sacre-Coeur de Montreal, Montréal, Quebec, Canada|CHU de Québec - Université Laval, Québec, Quebec, Canada|IUCPQ-UL, Québec, Quebec, Canada|Centre Hospitalier de l'Université de Sherbrooke, Sherbrooke, Quebec, Canada|Regina General Hospital, Saskatoon, Saskatchewan, Canada|Universidad de La Sabana, Chía, Cundinamarca, Colombia|General County Hospital Požega, Požega, Croatia|University Hospital Centre Zagreb, Zagreb, Croatia|University Hospital for Infectious Diseases, Zagreb, Croatia|Charité - Universitätsmedizin Berlin - Infektiologie und Pneumologie, Berlin, Germany|Charité - Universitätsmedizin Berlin - Nephrologie, Berlin, Germany|Vivantes Klinikum Neukölln, Berlin, Germany|Universitätsklinikum Köln, Cologne, Germany|Universitätsklinikum Frankfurt, Frankfurt, Germany|University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany|Medizinische Hochschule Hannover, Hannover, Germany|Universitätsklinikum Jena, Jena, Germany|Universitätsklinikum Leipzig, Leipzig, Germany|Universitäts Klinikum Tübingen, Tübingen, Germany|Universitätsklinikum Würzburg, Würzburg, Germany|Jósa András County Hospital, Nyíregyháza, Hungary|Csolnoky Ferenc Kórház - Veszprem County Hospital, Veszprém, Hungary|Almási Balogh Pál Kórház, Ózd, Hungary|Apollo Main Hospital, Chennai, Tamil Nadu, India|Apollo First Med Hospital, Chennai, Tamil Nadu, India|Apollo Vanagaram Hospital, Chennai, Tamil Nadu, India|Apollo Speciality Hospital - OMR, Chennai, Tamil Nadu, India|Beaumont Hospital, Dublin, Ireland|St. Vincent's University Hospital, Dublin, Ireland|University Hospital Galway, Galway, Ireland|St Marianna University School of Medicine, Kawasaki, Kanagawa, Japan|Yokohama City University Hospital, Yokohama, Kanagawa, Japan|St. Marianna University Yokohama City Seibu Hospital, Yokohama, Kanagawa, Japan|Saiseikai Kumamoto Hospital, Minami, Kumamoto, Japan|Osaka City General Hospital, Osaka, Japan|Nerima Hikarigaoka Hospital, Tokyo, Japan|Tokyo Metropolitan Bokutoh Hospital, Tokyo, Japan|Itabashi Chuo Medical Center, Tokyo, Japan|Tokyo bay Urayasu-Ichikawa Medical Center, Tokyo, Japan|Wakayama Medical University, Wakayama, Japan|Chitwan Medical College, Bharatpur, Nepal|Grande International Hospital, Kathmandu, Nepal|Hospital for Advanced Medicine and Surgery (HAMS), Kathmandu, Nepal|Nepal Mediciti, Kathmandu, Nepal|Meander Medisch Centrum, Amersfoort, Netherlands|Jeroen Bosch Ziekenhuis, Den Bosch, Netherlands|Martini Hospital Groningen, Groningen, Netherlands|University Medical Center Groningen, Groningen, Netherlands|Leiden University Medical Center, Leiden, Netherlands|Canisius Wilhelmina Ziekenhuis, Nijmegen, Netherlands|Radboud University Medical Center, Nijmegen, Netherlands|University Medical Center Utrecht, Utrecht, Netherlands|North Shore Hospital, Auckland, New Zealand|CVICU, Auckland City Hospital, Auckland, New Zealand|DCCM, Auckland City Hospital, Auckland, New Zealand|Middlemore Hospital, Auckland, New Zealand|Christchurch Hospital, Christchurch, New Zealand|Waikato Hospital, Hamilton, New Zealand|Taranaki Base Hospital, New Plymouth, New Zealand|Rotorua Hospital, Rotorua, New Zealand|Tauranga Hospital, Tauranga, New Zealand|Wellington Regional Hospital, Wellington, New Zealand|Whangarei Hospital, Whangarei, New Zealand|Ziauddin University Hospital Clifton Campus, Karachi, Sindh, Pakistan|Abbasi Shaheed Hospital, Karachi, Sindh, Pakistan|National Institute of Cardiovascular Diseases, Karachi, Karachi, Sindh, Pakistan|South City Hospital, Karachi, Karachi, Sindh, Pakistan|Ziauddin University North Nazimabad Campus, Karachi, Sindh, Pakistan|Centro Hospitalar do Medio Tejo, Abrantes, Portugal|Hospital Lusíadas Lisbon, Lisboa, Portugal|Clinical Hospital of Infectious and Tropical Diseases "Dr. Victor Babes", Bucharest, Romania|King Abdulaziz Medical City, Riyadh, Saudi Arabia|Institut Hospital del Mar d'Investigacions Mèdiques, Barcelona, Spain|Hospital Universitario Reina Sofia, Córdoba, Spain|Basildon Hospital, Basildon, England, United Kingdom|Basingstoke and North Hampshire Hospital, Basingstoke, England, United Kingdom|Royal United Hospital, Bath, Bath, England, United Kingdom|Queen Elizabeth Hospital Birmingham, Birmingham, England, United Kingdom|Birmingham City Hospital, Birmingham, England, United Kingdom|Blackburn Hospital, Blackburn, England, United Kingdom|Pilgrim's Hospital, Boston, England, United Kingdom|Royal Bournemouth Hospital, Bournemouth, England, United Kingdom|Royal Sussex County Hospital, Brighton, England, United Kingdom|Southmead Hospital, Bristol, England, United Kingdom|Bristol Royal Hospital, Bristol, England, United Kingdom|Queen's Hospital, Burton, Burton on Trent, England, United Kingdom|Royal Papworth Hospital, Cambridge, England, United Kingdom|Addenbrookes Hospital, Cambridge, England, United Kingdom|Cumberland Royal Infirmary, Carlisle, England, United Kingdom|Ashford & St Peters Hospital Trust, Chertsey, England, United Kingdom|Chesterfield Royal Hospital, Chesterfield, England, United Kingdom|Countess of Chester Hospital, Chester, England, United Kingdom|Colchester Hospital, Colchester, England, United Kingdom|University Hospital Coventry, Coventry, England, United Kingdom|North Manchester General Hospital, Crumpsall, England, United Kingdom|Darlington Memorial Hospital, Darlington, England, United Kingdom|Darent Valley Hospital, Dartford, England, United Kingdom|Russells Hall Hospital, Dudley, England, United Kingdom|University Hospital of North Durham, Durham, England, United Kingdom|Royal Devon and Exeter Hospital, Exeter, England, United Kingdom|Frimley Park Hospital, Frimley, England, United Kingdom|Queen Elizabeth Hospital, Gateshead, England, United Kingdom|Medway Maritime Hospital, Gillingham, England, United Kingdom|James Paget Kings Lynn Hospital, Great Yarmouth, England, United Kingdom|Royal Surrey County Hospital, Guildford, England, United Kingdom|Northwick Park Hospital, Harrow, England, United Kingdom|Hereford County Hospital, Hereford, England, United Kingdom|Barnet Hospital, High Barnet, England, United Kingdom|Huddersfield Hospital, Huddersfield, England, United Kingdom|King George Hospital, Ilford, England, United Kingdom|Ipswich Hospital, Ipswich, England, United Kingdom|Kettering Hospital, Kettering, England, United Kingdom|Leeds Teaching Hospitals NHS Trust, Leeds, England, United Kingdom|Leicester Royal Infirmary, Leicester, England, United Kingdom|Glenfield Hospital, Leicester, England, United Kingdom|Lincoln County Hospital, Lincoln, England, United Kingdom|Liverpool Heart and Chest Hospital, Liverpool, England, United Kingdom|Alder Hey Hospital, Liverpool, England, United Kingdom|Royal Liverpool Hospital, Liverpool, England, United Kingdom|University Hospital Aintree, Liverpool, England, United Kingdom|Croydon University Hospital, London, England, United Kingdom|Royal London Hospital, London, England, United Kingdom|Whipps Cross Hospital, London, England, United Kingdom|Newham Hospital, London, England, United Kingdom|St Barts Hosptial, London, England, United Kingdom|North Middlesex Hospital, London, England, United Kingdom|Royal Free Hospital, London, England, United Kingdom|St Thomas' Hospital, London, England, United Kingdom|Guy's Hospital, London, England, United Kingdom|King's College Hospital, London, England, United Kingdom|St George's Hospital, London, England, United Kingdom|Royal Marsden Hospital, London, England, United Kingdom|Ryal Brompton, London, England, United Kingdom|Hammersmith Hospital, London, England, United Kingdom|St Mary's Hospital, London, England, United Kingdom|Charing Cross Hospital, London, England, United Kingdom|Luton and Dunstable University Hospital, Luton, England, United Kingdom|Maidstone Hospital - Maidstone and Tunbridge Wells NHS Trust, Maidstone, England, United Kingdom|Manchester Royal Infirmary, Manchester, England, United Kingdom|The Christie Hospital, Manchester, England, United Kingdom|Wythenshawe Hospital, Manchester, England, United Kingdom|Queen Elizabeth Hospital, Woolwich, Margate, England, United Kingdom|The James Cook University Hospital, Middlesbrough, England, United Kingdom|Milton Keynes University Hospital, Milton Keynes, England, United Kingdom|Royal Victoria Infirmary, Newcastle, Newcastle, England, United Kingdom|Newcastle Freeman Hospital, Newcastle, England, United Kingdom|Northampton General Hospital, Northampton, England, United Kingdom|Norfolk and Norwich University Hospital, Norwich, England, United Kingdom|City Hospital Nottingham, Nottingham, England, United Kingdom|Queen's Medical Centre - Nottingham University Hospitals NHS Trust, Nottingham, England, United Kingdom|George Eliot Hospital, Nuneaton, England, United Kingdom|Royal Oldham Hospital, Oldham, England, United Kingdom|Princess Royal University Hospital, Orpington, England, United Kingdom|John Radcliffe Hospital, Oxford, England, United Kingdom|Derriford Hospital, Plymouth, England, United Kingdom|Poole Hospital NHS Foundation Trust, Poole, England, United Kingdom|Queen Alexandra Hospital - Portsmouth Hospitals NHS Trust, Portsmouth, England, United Kingdom|Whiston Hospital, Prescot, England, United Kingdom|Royal Preston Hospital, Preston, England, United Kingdom|Royal Berkshire Hospital, Reading, England, United Kingdom|Alexandra Hospital, Redditch, Redditch, England, United Kingdom|Queen's Hospital Romford, Romford, England, United Kingdom|Rotherham General Hospital, Rotherham, England, United Kingdom|Salford Royal Hospital, Salford, England, United Kingdom|Salisbury District Hospital, Salisbury, England, United Kingdom|Royal Hallamshire Hospital, Sheffield, England, United Kingdom|Northern General Hospital, Sheffield, England, United Kingdom|Wexham Park Hospital, Slough, England, United Kingdom|South Tyneside District Hospital, South Shields, England, United Kingdom|Southampton General Hospital, Southampton, England, United Kingdom|Stepping Hill Hospital, Stockport, England, United Kingdom|University Hospital of North Tees, Stockton-on-Tees, England, United Kingdom|Royal Stoke University Hospital, Stoke-on-Trent, England, United Kingdom|Sunderland Hospital, Sunderland, England, United Kingdom|King's Mill Hospital, Sutton In Ashfield, England, United Kingdom|Great Western Hospital, Swindon, England, United Kingdom|Western General Hospital, Swindon, England, United Kingdom|Musgrove Park Hospital, Taunton, England, United Kingdom|Torbay and South Devon Hospital, Torquay, England, United Kingdom|Royal Cornwall Hospital, Truro, England, United Kingdom|Tunbridge Wells Hospital - Maidstone and Tunbridge Wells NHS Trust, Tunbridge Wells, England, United Kingdom|Harefield Hospital, Uxbridge, England, United Kingdom|Watford General Hospital, Watford, England, United Kingdom|Southend University Hospital, Westcliff-on-Sea, England, United Kingdom|West Cumberland Hospital, Whitehaven, England, United Kingdom|Royal Albert Edward Infirmary, Wigan, England, United Kingdom|Royal Hampshire Hospital, Winchester, England, United Kingdom|Arrow Park Hospital, Wirral, England, United Kingdom|New Cross Hospital, Wolverhampton, England, United Kingdom|Worcester Royal Hospital, Worcester, England, United Kingdom|York Hospital, York, England, United Kingdom|York Hospital, York, England, United Kingdom|Antrim Area Hospital, Antrim, Northern Ireland, United Kingdom|Royal Victoria Hospital, Belfast, Belfast, Northern Ireland, United Kingdom|Mater Hospital, Belfast, Northern Ireland, United Kingdom|Belfast City Hospital, Belfast, Northern Ireland, United Kingdom|Altnagelvin Hospital, Derry, Northern Ireland, United Kingdom|Aberdeen Royal Infirmary, Aberdeen, Scotland, United Kingdom|Ninewells Hospital, Dundee, Scotland, United Kingdom|Royal Infirmary of Edinburgh, Edinburgh, Scotland, United Kingdom|Glasgow Royal Infirmary, Glasgow, Scotland, United Kingdom|Queen Elizabeth University Hospital, Glasgow, Glasgow, Scotland, United Kingdom|Royal Alexandra Hospital, Glasgow, Paisley, Scotland, United Kingdom|Neville Hall Hospital, Abergavenny, Wales, United Kingdom|Glan Clywd Hospital, Bodelwyddan, Wales, United Kingdom|Princess of Wales Hospital, Bridgend, Wales, United Kingdom|University Hospital of Wales, Cardiff, Wales, United Kingdom|Glangwilli Hospital, Carmarthen, Wales, United Kingdom|Grange University Hospital, Cwmbran, Wales, United Kingdom|Royal Gwent Hospital, Newport, Wales, United Kingdom|Royal Glamorgan Hospital, Pontyclun, Wales, United Kingdom|Morriston Hospital, Swansea, Wales, United Kingdom|Wrexham Maelor Hospital, Wrexham, Wales, United Kingdom
  • Study designs - Allocation: Randomized|Intervention Model: Factorial Assignment|Masking: None (Open Label)|Primary Purpose: Treatment
  • Enrollment - 10000
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - All-cause mortality|Days alive and not receiving organ support in ICU|ICU Mortality|ICU length of stay|Hospital length of stay|Ventilator free days|Organ failure free days|Health-related Quality of life assessment|Proportion of intubated patients who receive a tracheostomy|Destination at time of hospital discharge|Readmission to the index ICU during the index hospitalization|World Health Organisation 8-point ordinal scale outcome
NCT04344964 Endoscopy-related Phone Consultation During the COVID-19 Outbreak Completed Apr/15/2020 Jul/03/2020
  • Alternative id - 38839
  • Interventions - Other: None - NA
  • Study type - Observational
  • Study results - No Results Available
  • Locations - Austin Health, Melbourne, Victoria, Australia
  • Study designs - Observational Model: Case-Control|Time Perspective: Prospective
  • Enrollment - 186
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Failed to attend patients|Patient satisfaction with the phone consult|Consultant satisfaction with the phone consult
NCT04583865 Feasibility and Quality of TeleConsultation in Pediatric Anesthesia Active, not recruiting Oct/07/2020 Mar/14/2022
  • Alternative id - RC31/20/0220|2020-A02275-34
  • Interventions - Other: teleconsultation
  • Study type - Observational
  • Study results - No Results Available
  • Locations - UHToulouse, Toulouse, France
  • Study designs - Observational Model: Cohort|Time Perspective: Prospective
  • Enrollment - 400
  • Age - 1 Month to 18 Years   (Child, Adult)
  • Outcome measures - assess the feasibility of teleconsultation (TLC) in pediatric anesthesia in France in the context of the COVID 19 pandemic.
NCT04714138 Remote Video Consultation for Quality of Life Assessment in Patients Hospitalised After COVID-19 Infection Completed Jan/05/2021 Jun/15/2021
  • Alternative id - 2020-A03110-39
  • Interventions -
  • Study type - Observational
  • Study results - No Results Available
  • Locations - Groupe Hospitalier Du Havre, Montivilliers, Normandie, France
  • Study designs - Observational Model: Cohort|Time Perspective: Prospective
  • Enrollment - 157
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Health-related quality of life|Functional capacity|Independency
NCT04378244 CORONA: A Study Using DeltaRex-G Gene Therapy for Symptomatic COVID-19 Not yet recruiting Phase 1|Phase 2 Dec/12/2021 Mar/12/2022
  • Alternative id - AF20-203
  • Interventions - Drug: DeltaRex-G
  • Study type - Interventional
  • Study results - No Results Available
  • Locations -
  • Study designs - Allocation: N/A|Intervention Model: Single Group Assignment|Masking: None (Open Label)|Primary Purpose: Treatment
  • Enrollment - 18
  • Age - 18 Years to 100 Years   (Adult, Older Adult)
  • Outcome measures - Maximum Tolerated Dose|Survival|Hospital Stay|Ventilator Therapy|Intensive Care Unit Stay|Cytokine Pattern
NCT04558463 The Effectivity and Safety of Favipiravir Compared to Oseltamivir as Adjuvant Therapy for COVID-19 Recruiting Phase 3 Apr/16/2020 Oct/30/2020
  • Alternative id - 20-04-0455
  • Interventions - Drug: Favipiravir|Drug: Oseltamivir 75mg
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Cipto Mangunkusumo National Referral Hospital, Jakarta, DKI Jakarta, Indonesia
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: None (Open Label)|Primary Purpose: Treatment
  • Enrollment - 100
  • Age - 18 Years to 75 Years   (Adult, Older Adult)
  • Outcome measures - Clinical radiologic changes|Percentage of RT-PCR test convertion|Adverse event|Hospital length of stay (LOS)|Case Fatality Rate (CFR)
NCT05183672 Improving Post-acute Stroke Follow-up Care by Adopting Telecare Consultations in a Nurse-led Clinic Not yet recruiting Not Applicable Jul/01/2022 Jun/30/2025
  • Alternative id - A0036516
  • Interventions - Procedure: Telecare consultation|Procedure: Usual face-to-face consultation
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Queen Elizabeth Hospital, Kowloon, Hong Kong
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Single (Outcomes Assessor)|Primary Purpose: Health Services Research
  • Enrollment - 196
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Chang in Degree of disability after stroke|Incidence of the recurrence of stroke|Change of Quality of life, which measures an individual perception oftheir position in life. It includes physical and mental health.|Change of Post-stroke depression|Change of Medication adherence|Change of Social participation|Number of attendances at a general practitioners' office, emergency department, hospital, and general out-patient clinic
NCT04457609 Administration of Allogenic UC-MSCs as Adjuvant Therapy for Critically-Ill COVID-19 Patients Recruiting Phase 1 Jul/01/2020 Sep/01/2020
  • Alternative id - ISMMSCCOVID19
  • Interventions - Drug: Oseltamivir|Drug: Azithromycin|Biological: Umbilical Cord Mesenchymal Stem Cells
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Cipto Mangunkusumo General Hospital, Jakarta Pusat, DKI Jakarta, Indonesia|Persahabatan General Hospital, Jakarta, DKI Jakarta, Indonesia|Sulianti Saroso Center for Infectious Disease, Jakarta, DKI Jakarta, Indonesia|Universitas Indonesia Hospital, Depok, West Java, Indonesia
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Triple (Participant, Investigator, Outcomes Assessor)|Primary Purpose: Treatment
  • Enrollment - 40
  • Age - 18 Years to 95 Years   (Adult, Older Adult)
  • Outcome measures - Clinical improvement: Presence of dyspnea|Clinical improvement: presence of sputum|Clinical improvement: fever|Clinical improvement: ventilation status|Clinical improvement: blood pressure|Clinical improvement: heart rate|Clinical improvement: respiratory rate|Clinical improvement: oxygen saturation|General laboratory outcome from leukocyte level|General laboratory outcome from lymphocytes level|General laboratory outcome from blood pH|General laboratory outcome from blood level of CO2|General laboratory outcome from blood base excess level|General laboratory outcome from blood oxygen partial pressure|General laboratory outcome from blood level of HCO3|General laboratory outcome from blood level of O2 saturation|General laboratory outcome from level of CRP|General laboratory outcome from level of SGOT/SGPT (AST/ALT)|General laboratory outcome from the level of ureum/creatinine level|General laboratory outcome from the level of eGFR|General laboratory outcome from the level of sodium|General laboratory outcome from the level of potassium|General laboratory outcome from the level of chloride|Changes in procalcitonin level|General laboratory outcome from albumin level|General laboratory outcome from total bilirubin level|Changes in D-Dimer level|Changes in fibrinogen level|Cardiac changes from troponin level|Cardiac changes from NT proBNP level|Changes in Leukemia Inhibiting Factor|Changes in level of IL-6|Changes in level of IL-10|Changes in level of vascular endothelial growth factor (VEGF)|Changes in level of ferritin|Changes in level of CXCR3|Changes in level of CD4|Changes in level of CD8|Changes in level of CD56|Radiologic Improvement from Chest X-Ray/CT Scan
NCT05273528 The Immunogenicity and Safety of V-01-351/V-01D Bivalence Vaccine Active, not recruiting Phase 2 Jan/11/2022 Jan/06/2023
  • Alternative id - V-01-351/V-01D-Booster-02
  • Interventions - Biological: Recombinant SARS-CoV-2 Beta Variant Fusion Protein Vaccine/Recombinant SARS-CoV-2 Delta Variant Fusion Protein Vaccine
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Shaoguan Hospital of Chinese Medicine, Shaoguan, Guangdong, China
  • Study designs - Allocation: N/A|Intervention Model: Single Group Assignment|Masking: None (Open Label)|Primary Purpose: Prevention
  • Enrollment - 20
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - GMT of neutralizing antibody|GMI of neutralizing antibody|Seroconversion rate of neutralizing antibody
NCT05244330 Effectiveness of COVID-19 Vaccines Against the SARS-COV-2 Delta (B.1.617.2) Completed Dec/15/2021 Jan/15/2022
  • Alternative id - XJTU1AF2022LSK-001
  • Interventions -
  • Study type - Observational
  • Study results - No Results Available
  • Locations - First Affiliated Hospital of Xian JiaotongUniversity, Xi'an, Shaanxi, China
  • Study designs - Observational Model: Cohort|Time Perspective: Retrospective
  • Enrollment - 1500
  • Age - Child, Adult, Older Adult
  • Outcome measures - the proportion of severe and critical cases|the duration of viral shedding
NCT04990570 Telemedicine (Virtual Clinic) for Pediatric Surgery During Covid-19 Pandemic Completed Jun/01/2019 Jul/31/2021
  • Alternative id - Al-AzharTelemedicineinCovid-19
  • Interventions - Other: Telemedicine in the form Virtual clinic via video consultation
  • Study type - Observational
  • Study results - No Results Available
  • Locations - Muhammad Elsayed Abdelhafez Mahmoud, Riyadh, Saudi Arabia
  • Study designs - Observational Model: Case-Control|Time Perspective: Prospective
  • Enrollment - 1396
  • Age - 1 Month to 14 Years   (Child)
  • Outcome measures - Age of patients|Condition distribution|Conversation duration|Attendance rate|Cancellation rate|Rate of re-admissions|Ultimate fate of the interview|Patient satisfaction questionnaire
NCT04934202 Cohort Follow-up of Survivors of Hospitalization for COVID-19 During the 2nd Wave of the Epidemic in France Recruiting May/05/2021 May/05/2022
  • Alternative id - COMEBAC 2
  • Interventions - Other: Teleconsultation|Other: Outpatient clinic
  • Study type - Observational
  • Study results - No Results Available
  • Locations - Bicetre hospital, Le Kremlin-Bicêtre, France
  • Study designs - Observational Model: Cohort|Time Perspective: Prospective
  • Enrollment - 500
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Prevalence of respiratory, cognitive and psychological symptoms presented at 6 months of hospitalization for COVID-19.|Difference between the prevalence of residual symptoms between patients hospitalized during the 1st wave of the epidemic in France (from the COMEBAC "1st wave" study) and those of the current study|Association between patient characteristics and the prevalence of residual symptoms.|Association between residual symptoms and the type of SARS-CoV-2 variant|Prevalence of respiratory, neurological, cognitive and psychological symptoms presented at 6 months of hospitalization for COVID-19 which occurred during the 1st epidemic wave.
NCT04368832 imPROving prenaTal carE During ConfinemenT Active, not recruiting Apr/25/2020 Sep/30/2021
  • Alternative id - 2020-A01023-36
  • Interventions - Other: Remote consultation
  • Study type - Observational
  • Study results - No Results Available
  • Locations - Maternité Régionale Universitaire de Nancy, Nancy, France
  • Study designs - Observational Model: Other|Time Perspective: Prospective
  • Enrollment - 108
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Score of perceived quality of prenatal care|Level of stress during pregnancy|level of health and digital literacy|Obstetrical outcomes|Characteristics of medical supervision during pregnancy
NCT04516668 Effect of Tele-consultation in Addition With Psychiatric Follow-up During COVID-19 in Women Who Have Medical History of Post-partum Depression Not yet recruiting Nov/01/2020 Nov/01/2020
  • Alternative id - APHP200878
  • Interventions -
  • Study type - Observational
  • Study results - No Results Available
  • Locations -
  • Study designs - Observational Model: Cohort|Time Perspective: Retrospective
  • Enrollment - 250
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Evaluation of Hospital anxiety and depression scale (HAD)|Evaluation of Edinburgh Postpartum Depression Scale (EPDS)|Evaluation of HAD score in fathers|Evaluation of EPDS in fathers|Study of the relationship between maternals and paternals symptoms|Study of difficuties in child during the quarantine|Risk and protection factors
NCT04710394 Visual-OLfactory Training in Participants With COVID-19 Resultant Loss of Smell Active, not recruiting Not Applicable Jan/11/2021 Mar/11/2022
  • Alternative id - 7011897206
  • Interventions - Behavioral: Smell Training
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Washington University School of Medicine in Saint Louis, Saint Louis, Missouri, United States
  • Study designs - Allocation: Randomized|Intervention Model: Factorial Assignment|Masking: Double (Participant, Care Provider)|Primary Purpose: Treatment
  • Enrollment - 240
  • Age - 18 Years to 70 Years   (Adult, Older Adult)
  • Outcome measures - University of Pennsylvania Smell Identification Test (UPSIT)|Clinical Global Impression Severity (CGI-S) Scale|Clinical Global Impression Improvement (CGI-I) Scale|Olfactory Dysfunction Outcomes Rating (ODOR)
NCT04452630 Cardiovascular Consequences After COVID-19 Recruiting Jun/23/2020 Nov/30/2021
  • Alternative id - 2020-36
  • Interventions - Other: Infectious Disease and Cardiology Clinical Consultations
  • Study type - Observational
  • Study results - No Results Available
  • Locations - Assistance Publique Hôpitaux de Marseille, Marseille, France
  • Study designs - Observational Model: Cohort|Time Perspective: Prospective
  • Enrollment - 200
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Presence of at least one clinical, biological and/or imaging cardiovascular anomaly within 1 month of recovering
NCT04806477 Diagnostic Accuracy Comparison Between Telemedicine and Face-to-face Consultations in Respiratory Infection Patients. Completed Not Applicable Sep/01/2020 Nov/01/2020
  • Alternative id - 34172720400000071
  • Interventions - Other: Telemedicine Consultation|Other: Face-to-face Consultation
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Hospital Israelita Abert Einstein, São Paulo, SP, Brazil
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: None (Open Label)|Primary Purpose: Diagnostic
  • Enrollment - 98
  • Age - 18 Years to 65 Years   (Adult, Older Adult)
  • Outcome measures - Number of final evaluation ICD 10-code diagnosis.|Time of medical care|Rate of indication for complementary exams|Type of requested exams|Type of Medical prescription|Type of proposed destination after completion of the service
NCT04645563 Using Whatsapp for the Consultation Completed Mar/11/2020 May/31/2020
  • Alternative id - Clinical-3
  • Interventions - Other: Sending thorax ct video images via smartphone applications
  • Study type - Observational
  • Study results - No Results Available
  • Locations - Ramazan Sabirli, Kars, Outside Of The US, Turkey
  • Study designs - Observational Model: Case-Control|Time Perspective: Retrospective
  • Enrollment - 144
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Analyzing the effect of consultation via whatsapp to lenght of stay the patients in emergency medicine department.|Comparing the effect of bedside consultation and consultation via whatsapp on patient discharge or hospitalisation and readmission.
NCT04668170 Predictive Immune Biomarkers of COVID-19 Pathogenesis to Influence Therapeutic Management Recruiting May/05/2020 Dec/31/2021
  • Alternative id - RC31/20/0187
  • Interventions - Biological: Blood collection on admission and longitudinally|Biological: Blood collection on their first consultation and 10 to 14 days later
  • Study type - Observational
  • Study results - No Results Available
  • Locations - University Hospital Bordeaux, Bordeau, France|University Hospital Toulouse, Toulouse, France
  • Study designs - Observational Model: Cohort|Time Perspective: Retrospective
  • Enrollment - 340
  • Age - 18 Years to 110 Years   (Adult, Older Adult)
  • Outcome measures - Immune signature on admission : phenotypic profile of blood T-cells|Immune signature on admission : inflammatory cytokines|Dynamics of cellular immunity: CD4 and CD8 T cells|Dynamics of cellular immunity: gd T cells|Dynamics of cellular immunity: T cell transcriptomic analysis|Dynamics of cellular immunity: humoral immunity
NCT04371107 Proactive Care of Ambulatory COVID19 Patients Not yet recruiting Phase 3 Apr/29/2020 Jul/01/2020
  • Alternative id - PI2020_843_0039
  • Interventions - Other: consultation|Drug: Azithromycin
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - CHU Amiens, Amiens, France
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: None (Open Label)|Primary Purpose: Treatment
  • Enrollment - 64
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Length of symptom duration (in days) with azithromycin treatment
NCT04768413 Evaluation of a Non-face to Face Multidisciplinary Health Care Model in a Population With Rheumatoid Arthritis Recruiting Jun/01/2020 Jun/30/2021
  • Alternative id - 5171
  • Interventions - Other: Teleconsultation either by phone or by computer consultation. Quantitative and qualitative approaches to analysis|Other: Care modalities. Quantitative and qualitative approaches to analysis
  • Study type - Observational
  • Study results - No Results Available
  • Locations - BIOMAP IPS Centro de Atención Integral en Artritis Reumatoide, Bogota, Cundinamarca, Colombia|Colombia Fundación Universitaria de Ciencias de la Salud-FUCS, Bogota, Cundinamarca, Colombia
  • Study designs - Observational Model: Cohort|Time Perspective: Prospective
  • Enrollment - 200
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Evaluation of the implementation of a non-face-to-face multidisciplinary consultation model in a population of rheumatoid arthritis|Epidemiological characterization|Proportion of individuals infected|Risk factors for infection|Risk factors for hospitalization|Risk factors for mortality|Average change from baseline in Disease Activity Score with 28-joint counts [DAS28] in face-to-face consultation group|Average change from baseline in Patient Activity Scale scores in both groups tele-assisted consultation and face-to-face consultation|Evaluation of participant's pain using visual analogue scale [VAS] in both groups tele-assisted consultation and face-to-face consultation|Evaluation of the disease activity by Doctor using visual analogue scale [VAS] in both groups tele-assisted consultation and face-to-face consultation|Absolute and percent change in the Health Assessment Questionnaire (HAQ) in both groups tele-assisted consultation and face-to-face consultation|Average change from baseline in European Quality of Life 5 Dimensions (EQ-5D) questionnaire in both groups tele-assisted consultation and face-to-face consultation|Evaluation of the level of therapeutic adherence using a specific Scale in both groups tele-assisted consultation and face-to-face consultation|Evaluation of the self-care capacity using the Appraisal of Self-care Agency Scale -Revised (ASA-R) in both groups tele-assisted consultation and face-to-face consultation
NCT04370171 Management of Diabetic Patients With Telemedicine in the Context of the Covid-19 Epidemic Completed May/04/2020 May/29/2020
  • Alternative id - 7775
  • Interventions - Other: care modalities|Other: Teleconsultation either by phone or by computer consultation
  • Study type - Observational
  • Study results - No Results Available
  • Locations - Hôpitaux Universitaires de Strasbourg, Strasbourg, France
  • Study designs - Observational Model: Cohort|Time Perspective: Prospective
  • Enrollment - 610
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Comparison of metabolic control (HbA1C) between diabetic patients followed by teleconsultation and patients with a conventional follow-up during Covid-19 infection.|HbA1C measured at 6 months post-telemedicine consultation for the TC group / post-cancellation of the face-to-face consultation for the P group.|Total number of patients inaccessible to teleconsultation and number of patients inaccessible by type of associated reason.|Number of complications: severe hypoglycemia, ketoacidosis, myocardial infarction, stroke, foot ulcer.|Results of patient satisfaction questionnaire.|Results of doctor satisfaction questionnaire.|Number of patients infected with Covid-19 (positive smear by RT-PCR for SARS-CoV-2 virus).|Number of conventional hospitalizations, in intensive care and deaths.
NCT04255017 A Prospective/Retrospective,Randomized Controlled Clinical Study of Antiviral Therapy in the 2019-nCoV Pneumonia Unknown status Phase 4 Feb/01/2020 Jul/01/2020
  • Alternative id - TJ20200128
  • Interventions - Drug: Abidol hydrochloride|Drug: Oseltamivir|Drug: Lopinavir/ritonavir
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Department and Institute of Infectious Disease, Wuhan, Hubei, China
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Single (Participant)|Primary Purpose: Treatment
  • Enrollment - 400
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Rate of disease remission|Time for lung recovery|Rate of no fever|Rate of respiratory symptom remission|Rate of lung imaging recovery|Rate of CRP,ES,Biochemical criterion(CK,ALT,Mb) recovery|Rate of undetectable viral RNA
NCT04660422 Advance Care Planning: Communicating With Outpatients for Vital Informed Decision Completed Dec/15/2020 Dec/31/2021
  • Alternative id - 20-600|UH3AG060626-03S1
  • Interventions - Other: VitalTalk communication skills training|Other: ACP Decisions Video Program|Other: Intervention training:|Other: Medical Record Review
  • Study type - Observational
  • Study results - No Results Available
  • Locations - Northwell Health, New Hyde Park, New York, United States
  • Study designs - Observational Model: Cohort|Time Perspective: Other
  • Enrollment - 42019
  • Age - 65 Years and older   (Older Adult)
  • Outcome measures - Rate for Advanced Care Planning (ACP) documentation|Rate of orders for resuscitation preferences|Rate of palliative care consultation|Rate of referral to hospice|Advanced Care Planning (ACP) documentation rates among under-represented minority groups.
NCT04371601 Safety and Effectiveness of Mesenchymal Stem Cells in the Treatment of Pneumonia of Coronavirus Disease 2019 Active, not recruiting Early Phase 1 Mar/01/2020 Dec/31/2022
  • Alternative id - MSC-CoViD-2020
  • Interventions - Drug: Oseltamivir|Drug: hormones|Device: oxygen therapy|Procedure: mesenchymal stem cells
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Fuzhou General Hospital, Fuzhou, Fujian, China
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: None (Open Label)|Primary Purpose: Treatment
  • Enrollment - 60
  • Age - 18 Years to 70 Years   (Adult, Older Adult)
  • Outcome measures - Changes of oxygenation index (PaO2/FiO2) ,blood gas test|Detection of TNF-α levels, IL-10 levels|Detection of immune cells that secret cytokines, including CXCR3+, CD4+, CD8+, NK+ cells, and regulatory T cells (CD4 + CD25 + FOXP3 + Treg cells).|Changes of c-reactive protein and calcitonin
NCT04261270 A Randomized,Open,Controlled Clinical Study to Evaluate the Efficacy of ASC09F and Ritonavir for 2019-nCoV Pneumonia Unknown status Phase 3 Feb/01/2020 Jul/01/2020
  • Alternative id - ASC09F-CTP-TJ-01
  • Interventions - Drug: ASC09F+Oseltamivir|Drug: Ritonavir+Oseltamivir|Drug: Oseltamivir
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Department and Institute of Infectious Disease, Wuhan, Hubei, China
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Single (Participant)|Primary Purpose: Treatment
  • Enrollment - 60
  • Age - 18 Years to 55 Years   (Adult)
  • Outcome measures - Rate of comprehensive adverse outcome|Time of clinical remission|Rate of no fever|Rate of no cough|Rate of no dyspnea|Rate of no need for oxygen inhalation|Rate of undetectable viral RNA|Rate of mechanical ventilation|Rate of ICU admission|Rate and time of CRP,ES,Biochemical criterion(CK,ALT,Mb)recovery
NCT05028361 Simultaneous mRNA COVID-19 and IIV4 Vaccination Study Recruiting Phase 4 Oct/04/2021 Jun/28/2022
  • Alternative id - Pro00109102
  • Interventions - Biological: mRNA COVID-19|Biological: IIV4|Other: Placebo
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - John Hopkins University, Baltimore, Maryland, United States|Duke University, Durham, North Carolina, United States|Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Triple (Participant, Care Provider, Outcomes Assessor)|Primary Purpose: Prevention
  • Enrollment - 450
  • Age - 12 Years and older   (Child, Adult, Older Adult)
  • Outcome measures - Number of participants with moderate or more severe fever, chills, myalgia, or arthralgia in the Simultaneous Group and the Sequential Group following both Vaccination Visit 1 and 2|Number of participants with moderate or more severe fever, chills, myalgia, or arthralgia in the Simultaneous versus the Sequential Group following the first vaccination visit|Number of participants with moderate or more severe fever, chills, myalgia, or arthralgia in the Simultaneous versus Sequential Group following the second vaccination visit|Number of participants in the Simultaneous and Sequential vaccination groups with solicited local and systemic reactogenicity events according to severity grade after the first, second and third vaccination visit|Observed serious adverse events in both treatment groups
NCT04973462 Evaluation of The Efficacy of Triazavirin Versus Oseltamivir in Egyptian Patients Infected With COVID-19 Recruiting Phase 4 Aug/01/2021 Dec/30/2021
  • Alternative id - Antiviral therapy in COVID-19
  • Interventions - Drug: standard treatment COVID-19 + Triazavirin
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Fever Hospital of the Egyptian Armed Forces, Cairo, Egypt
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Double (Participant, Care Provider)|Primary Purpose: Treatment
  • Enrollment - 80
  • Age - 18 Years to 60 Years   (Adult)
  • Outcome measures - Physicians Global Assessment to measure the baseline COVID-19 signs and symptoms|Time to recovery|Incidence of re-detection of viral RNA using PCR|Incidence of Treatment-Emergent Adverse Events [Safety and Tolerability]
NCT04623021 A Study Evaluating the Efficacy and Safety of CKD-314 (Nafabelltan) in Hospitalized Adult Patients Diagnosed With COVID-19 Pneumonia Completed Phase 2 Sep/25/2020 Dec/12/2020
  • Alternative id - A108_02CVD2014
  • Interventions - Drug: Nafamostat Mesilate
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - A108_02CVD2014 Site# 9, Barnaul, Russian Federation|A108_02CVD2014 Site# 26, Krasnoyarsk, Russian Federation|A108_02CVD2014 Site# 5, Moscow, Russian Federation|A108_02CVD2014 Site# 8, Moscow, Russian Federation|A108_02CVD2014 Site# 31, Ryazan, Russian Federation|A108_02CVD2014 Site# 25, St. Petersburg, Russian Federation|A108_02CVD2014 Site# 29, St. Petersburg, Russian Federation|A108_02CVD2014 Site# 30, St. Petersburg, Russian Federation|A108_02CVD2014 Site# 3, St. Petersburg, Russian Federation|A108_02CVD2014 Site# 4, St. Petersburg, Russian Federation|A108_02CVD2014 site#1, Ufa, Russian Federation
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: None (Open Label)|Primary Purpose: Treatment
  • Enrollment - 104
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Time to clinical improvement|Time to recovery|Proportion of patients with clinical improvement as defined by live discharge from hospital or a decline of 2 categories on the seven-category ordinal scale of clinical status|Proportion of patients with recovery as defined as the subject satisfies one of the following|Change of clinical status assessed by 7-category ordinal scale|Change in National Early Warning Score (NEWS)|Time to National Early Warning Score (NEWS) of ≤ 2 which is maintained for 24 hours|Changes on CT scan/X-ray|Change from baseline of CRP|Time to normalize the CRP|Duration of hospitalization|Duration of non-invasive ventilation or high flow oxygen use|Incidence of non-invasive ventilation or high flow oxygen use|Duration of supplement oxygen use|Incidence of supplement oxygen use|Duration of invasive ventilation or extracorporeal membrane oxygenation (ECMO) use|Incidence of invasive ventilation or extracorporeal membrane oxygenation (ECMO) use|28-Day mortality
NCT04338698 Hydroxychloroquine, Oseltamivir and Azithromycin for the Treatment of COVID-19 Infection: An RCT Completed Phase 3 Apr/22/2020 Nov/22/2020
  • Alternative id - 12(06)/2016-Coord
  • Interventions - Drug: Hydroxychloroquine|Drug: Oseltamivir|Drug: Azithromycin
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Faislabad Medical University, Faisalābad, Pakistan|Gujranwala Medical College, Gujrānwāla, Pakistan|Nawaz Sharif Medical College, Gujrāt, Pakistan|Szabmu-Pims, Islamabad, Pakistan|Akram Medical Complex, Lahore, Pakistan|Fatima Jinnah Medical University, Lahore, Pakistan|King Edward Medical University-Mayo Hospital, Lahore, Pakistan|Lahore General Hospital, Lahore, Pakistan|Khyber Teaching Hospital, Peshawar, Pakistan|Rawalpindi Medical University, Rawalpindi, Pakistan|Sargodha Medical College, Sargodha, Pakistan
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Double (Investigator, Outcomes Assessor)|Primary Purpose: Treatment
  • Enrollment - 550
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Laboratory Result|Clinical Outcome
NCT04817293 Prolonged Symptoms and Reasons for Consultation in Town Medicine Associated With COVID-19 Infection in the Hauts de France Region Recruiting Apr/06/2021 Dec/01/2021
  • Alternative id - RIPH_2021_01
  • Interventions - Other: Questionnaire|Other: medical consultation
  • Study type - Observational
  • Study results - No Results Available
  • Locations - CH Tourcoing, Tourcoing, France
  • Study designs - Observational Model: Case-Control|Time Perspective: Prospective
  • Enrollment - 1000
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - To compare the reasons for consultation between patients with a history of Covid 19 and those who have not been infected with SARS-CoV-2.|To Assess the presence of somatoform disorders between COVID-19 and non-COVID-19 patients.|To compare the quality of life of COVID-19 patients with that of non-COVID-19 patients.
NCT04412239 To Assess the Efficiency and Satisfaction of Pharmacist Giving Patient-centred Advice on Telephone Consultation in TB Patients: Experience of the COVID-19 Pandemic Recruiting Not Applicable Apr/20/2020 Dec/20/2020
  • Alternative id - NO, F6-2017/NTP-ADMIN
  • Interventions - Behavioral: Patient-centred advice on Telephone Consultation in TB Patients:
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Dhq Bannu Kpk, Bannu, KPK, Pakistan|District Bannu TB Control Center, Bannu, KPK, Pakistan
  • Study designs - Allocation: N/A|Intervention Model: Single Group Assignment|Masking: None (Open Label)|Primary Purpose: Other
  • Enrollment - 200
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Efficiency of the telephone consultation,|Patient satisfaction|Adherence Rate
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