Other substances

[3-(5-methoxy-2-hydroxy benzylidene amino)-2(5-methoxy-2-hydroxyphenyl)-2,3-dihydro quinazoline-4(1H)-one]

A protease inhibitor.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Experimental

1
 Supporting references
0
 Contradictory references
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 AI-suggested references
0
 Clinical trials

General information

[3-(5-methoxy-2-hydroxy benzylidene amino)-2(5-methoxy-2-hydroxyphenyl)-2,3-dihydro quinazoline-4(1H)-one] is a quinazoline compound, which inhibits the SARS-CoV-2 3C-like protease in vitro (Rothan et al., 2021).

Synonyms

Quinazoline derivative QZ4

 

Structure image - [3-(5-methoxy-2-hydroxy benzylidene amino)-2(5-methoxy-2-hydroxyphenyl)-2,3-dihydro quinazoline-4(1H)-one]

COC1=CC(C2NC3=CC=CC=C3C(=O)N2\N=C\C2=CC(OC)=CC=C2O)=C(O)C=C1

Supporting references

Link Tested on Impact factor Notes Publication date
Cell-Based High-Throughput Screening Protocol for Discovering Antiviral Inhibitors Against SARS-COV-2 Main Protease (3CLpro)
3CLpro Small molecule Enzyme assay In vitro 		in vitro enzyme assay 2.02

Inhibited the SARS-CoV-2 3C-like protease with EC50 of 6.5 µM and CC50 of >100 µM in vitro.

 Jan/19/2021
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