(2R,3R,4R,5R)-2-(4-Amino-5-fluoropyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)-3-methyloxolane-3,4-diol
A ribonucleoside analogue.
General information
(2R,3R,4R,5R)-2-(4-Amino-5-fluoropyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)-3-methyloxolane-3,4-diol is a 7-deaza-7-fluoropurine derivative. It inhibits SARS-CoV-2 in vitro (Zandi et al., 2020).
(2R,3R,4R,5R)-2-(4-Amino-5-fluoropyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)-3-methyloxolane-3,4-diol on PubChem
Synonyms
7-deaza-7-fluoropurine derivative 2
C[C@]1([C@@H]([C@H](O[C@H]1N2C=C(C3=C(N=CN=C32)N)F)CO)O)O
Supporting references
Link | Tested on | Impact factor | Notes | Publication date |
---|---|---|---|---|
Repurposing Nucleoside Analogs for Human Coronaviruses
Small molecule In vitro |
PBM and CEM cells (cytotoxicity only), Huh-7 cells; Vero CCL-81 cells; RD cells; Caco-2 cells; Calu3 cells; SARS-CoV-2 (NR-52281: USA-WA/2020) | 4.68 | Inhibits SARS-CoV-2 in a single-digit-micromolar range with no cytotoxicyty detected up to 100 μM in Vero cells. |
Oct/29/2020 |