27-hydroxycholesterol
A cholesterol metabolite.
C[C@H](CCC[C@@H](C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)O)C)C)CO
Supporting references
| Link | Tested on | Impact factor | Notes | Publication date |
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The cholesterol metabolite 27-hydroxycholesterol inhibits SARS-CoV-2 and is markedly decreased in COVID-19 patients
Small molecule In vitro |
Vero E6 cells; Huh7 cells; SARS-CoV-2 ICGEB_FVG_S5 strain | 9.99 | 27-hydroxycholesterol (27OHC) (complexed with 2-hydroxypropyl-β-cyclodextrin) manifested strong dose-responsive antiviral activity in vitro. The serum levels of 27OHC in severe COVID-19 patients was significantly lower than in moderate cases. |
Aug/10/2020 |
AI-suggested references
| Link | Publication date |
|---|---|
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Identification of Anti-Severe Acute Respiratory Syndrome-Related Coronavirus 2 (SARS-CoV-2) Oxysterol Derivatives In Vitro.
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Mar/19/2021 |
