Other substances

2-Hydroxy-4-(2-(tosyloxy)acetamido)benzoic acid

A STAT3 inhibitor.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Experimental

1
 Supporting references
0
 Contradictory references
0
 AI-suggested references
0
 Clinical trials

General information

2-Hydroxy-4-(2-(tosyloxy)acetamido)benzoic acid is a STAT3 dimerization inhibitor with anti-SARS-CoV-2 activity in Calu-3 cells but not in Vero E6 cells (Park et al., 2021).

2-Hydroxy-4-(2-(tosyloxy)acetamido)benzoic acid on PubChem

Synonyms

501919-59-1; S3I-201

 

Structure image - 2-Hydroxy-4-(2-(tosyloxy)acetamido)benzoic acid

CC1=CC=C(C=C1)S(=O)(=O)OCC(=O)NC2=CC(=C(C=C2)C(=O)O)O

Supporting references

Link Tested on Impact factor Notes Publication date
Differential Signaling and Virus Production in Calu-3 Cells and Vero Cells upon SARS-CoV-2 Infection
Small molecule In vitro 		Vero E6 cells; Calu-3 cells 3.47

Manifests anti-SARS-CoV-2 activity in Calu-3 cells but not in Vero E6 cells. The reason might be differential signalling and virus production in these cell lines.

 Jan/28/2021
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