Other substances

2-Ethyl-7,10,11-trimethoxy-3,4-dihydro-1H-phenanthro[9,10-c]pyridin-4-ol

A heterocyclic alkaloid.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Experimental

1
 Supporting references
0
 Contradictory references
0
 AI-suggested references
0
 Clinical trials

General information

2-Ethyl-7,10,11-trimethoxy-3,4-dihydro-1H-phenanthro[9,10-c]pyridin-4-ol is a tylophorine derivative with in vitro anti-SARS-CoV-2 activity (Yang et al., 2020).

2-Ethyl-7,10,11-trimethoxy-3,4-dihydro-1H-phenanthro[9,10-c]pyridin-4-ol on PubChem

Synonyms

dbq33b

 

Structure image - 2-Ethyl-7,10,11-trimethoxy-3,4-dihydro-1H-phenanthro[9,10-c]pyridin-4-ol

CCN1CC(C2=C(C1)C3=CC(=C(C=C3C4=C2C=CC(=C4)OC)OC)OC)O

Supporting references

Link Tested on Impact factor Notes Publication date
Inhibition of SARS-CoV-2 by Highly Potent Broad-Spectrum Anti-Coronaviral Tylophorine-Based Derivatives
Small molecule In vitro 		Vero E6 cells 4.23

Manifested in vitro anti-SARS-CoV-2 activity in Vero E6 cells with EC50 of 2.5 nM in a cytopathic effect assay, 13.9 nM in an immunofluorescence assay, and 14 nM in plaque assay with a selectivity index of 500 or 367.

 Dec/14/2020
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