Other substances

2′-C-methylguanosine

A nucleotide analogue precursor.

Phase of research

Potential treatment - theoretical effect

How it helps

Antiviral

Drug status

Experimental

1
 Supporting references
0
 Contradictory references
0
 AI-suggested references
0
 Clinical trials

General information

2′-C-methylguanosine can be metabolised into a nucleotide analogue 2′-C-methyl-GTP (Li et al., 2017).

2′-C-methylguanosine on PubChem

 

Structure image - 2′-C-methylguanosine

C[C@]1([C@@H]([C@H](O[C@H]1N2C=NC3=C2N=C(NC3=O)N)CO)O)O

Supporting references

Link Tested on Impact factor Notes Publication date
Development of a simple in vitro assay to identify and evaluate nucleotide analogs against SARS-CoV-2 RNA-dependent RNA polymerase
RdRpol Small molecule Enzyme assay In vitro 		in vitro enzyme assay 4.68

The 2′-C-methylguanosine triphosphate metabolite is incorporation into SARS-CoV-2 nascent RNA with high efficiency in vitro.

 Oct/29/2020
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