Other substances

2'-C-Methylcytidine

A ribonucleoside analogue.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Experimental

1
 Supporting references
0
 Contradictory references
0
 AI-suggested references
0
 Clinical trials

General information

2'-C-Methylcytidine is a ribonucleoside analogue, which experimentally induces mutations into viral RNA. It has been shown to inhibit hepatitis C virus replication (DrugBank).

2'-C-Methylcytidine on PubChem

 

Structure image - 2'-C-Methylcytidine

C[C@]1([C@@H]([C@H](O[C@H]1N2C=CC(=NC2=O)N)CO)O)O

Supporting references

Link Tested on Impact factor Notes Publication date
Repurposing Nucleoside Analogs for Human Coronaviruses
Small molecule In vitro 		PBM and CEM cells (cytotoxicity only), Huh-7 cells; Vero CCL-81 cells; RD cells; Caco-2 cells; Calu3 cells; SARS-CoV-2 (NR-52281: USA-WA/2020) 4.68

Inhibits SARS-CoV-2 in a single-digit-micromolar range with no cytotoxicyty detected up to 100 μM in Vero cells.

 Oct/29/2020
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