Other substances

2-((3,5-dichlorophenyl)amino)-5-hydroxyquinazolin-4 (3H)-one

An experimental anticoronaviral compound.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Experimental

1
 Supporting references
0
 Contradictory references
1
 AI-suggested references
0
 Clinical trials

General information

2-((3,5-dichlorophenyl)amino)-5-hydroxyquinazolin-4 (3H)-one is a 2-Aminoquinazolin-4(3H)-one derivative with anti-SARS-CoV-2 and anti-MERS-CoV properties in vitro (Lee et al., 2021).

(Structure image generated in SwissSimilarity)

Synonyms

11e

 

Structure image - 2-((3,5-dichlorophenyl)amino)-5-hydroxyquinazolin-4 (3H)-one

OC1=C2C(=O)NC(NC3=CC(Cl)=CC(Cl)=C3)=NC2=CC=C1

Supporting references

Link Tested on Impact factor Notes Publication date
Design, synthesis and biological evaluation of 2-aminoquinazolin-4(3H)-one derivatives as potential SARS-CoV-2 and MERS-CoV treatments
Small molecule In vitro 		Vero cells; SARS-CoV-2 2.57

Inhibited SARS-CoV-2 infection in Vero cells with an IC50 of 0.15 μM and an SI of 168.

 Mar/02/2021

AI-suggested references

Link Publication date
In silico and in vitro studies on inhibitors for SARS-CoV-2 non-structural proteins with dual herbal combination of Withania somnifera with five rasayana herbs.
Mar/08/2022
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