Other substances

2-[(1R)-1-Naphth-1-ylethyl]-2,3-dihydro-1H-isoindol hydrochloride

An isoindoline derivative.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Experimental

1
 Supporting references
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 Contradictory references
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 AI-suggested references
0
 Clinical trials

General information

2-[(1R)-1-Naphth-1-ylethyl]-2,3-dihydro-1H-isoindol  hydrochloride is an isoindoline derivative with anti-SARS-CoV-2 activity in vitro (Welker et al., 2020).

Synonyms

14h isoindoline derivative

 

C[C@@H](N1CC2=CC=CC=C2C1)C1=C2C=CC=CC2=CC=C1

Supporting references

Link Tested on Impact factor Notes Publication date
SAR of novel benzamides and isoindolines, designed as SARS‐CoV protease inhibitors – effective against SARS‐CoV‐2
3CLpro Small molecule Enzyme assay In vitro In silico 		in silico; in vitro enzyme assay; Vero E6 cells 3.12

The compound was suggested as a potential anti-SARS-CoV-2 drug because it displayed EC50 value of 7.85 µM against the viral infection and exhibited Papain-like protease inhibitory activity in vitro. It has also low toxicity.

 Sep/15/2020
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