Other substances

(1,3-Dimethylpyrazol-4-yl)-[4-(4-fluorophenyl)piperazin-1-yl]methanone

A pyrazole derivative.

Phase of research

Potential treatment - theoretical effect

How it helps

Antiviral

Drug status

Experimental

1
 Supporting references
0
 Contradictory references
0
 AI-suggested references
0
 Clinical trials

General information

(1,3-Dimethylpyrazol-4-yl)-[4-(4-fluorophenyl)piperazin-1-yl]methanone is a pyrazole derivative. It displays potent anti-inflammatory properties in macrophages in vitro via inhibition of NF‐ĸB signalling (Masih et al., 2020).

(1,3-Dimethylpyrazol-4-yl)-[4-(4-fluorophenyl)piperazin-1-yl]methanone on PubChem

Synonyms

6c pyrazole derivative

 

Structure image - (1,3-Dimethylpyrazol-4-yl)-[4-(4-fluorophenyl)piperazin-1-yl]methanone

CC1=NN(C=C1C(=O)N2CCN(CC2)C3=CC=C(C=C3)F)C

Supporting references

Link Tested on Impact factor Notes Publication date
Discovery of novel pyrazole derivatives as a potent anti‐inflammatory agent in RAW264.7 cells via inhibition of NF‐ĸB for possible benefit against SARS‐CoV‐2
Small molecule In silico 		in silico; RAW264.7 macrophages 3.61

Inhibits NFu2010u0138B transcription after lipopolysaccharide stimulation in vitro. It also decreases the levels of selected pro-inflammatory cytokines (IL-1β, TNFu2010α, IL-6) under such conditions.

 Oct/23/2020
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