Other substances

Digitoxin

A plasma membrane sodium-potassium ATPase inhibitor.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Used to treat other disease

Supporting references

Contradictory references

AI-suggested references

Clinical trials

General information

Digitoxin is a cardiac glycoside. It inhibits the plasma membrane sodium/potassium ATPase, which results in decreased intracellular potassium levels and increased intracellular sodium and calcium levels. Its activity leads to caspase activation and DNA fragmentation, causing apoptosis. Digitoxin was shown to inhibit cancer cell growth (NCIt).

Digitoxin on DrugBank
Digitoxin on PubChem
Digitoxin on Wikipedia

C[C@@H]1[C@H]([C@H](C[C@@H](O1)O[C@@H]2[C@H](O[C@H](C[C@@H]2O)O[C@@H]3[C@H](O[C@H](C[C@@H]3O)O[C@H]4CC[C@]5([C@@H](C4)CC[C@@H]6[C@@H]5CC[C@]7([C@@]6(CC[C@@H]7C8=CC(=O)OC8)O)C)C)C)C)O)O

Supporting references

Link	Tested on	Impact factor	Notes	Publication date
Screening of FDA-approved drugs using a MERS-CoV clinical isolate from South Korea identifies potential therapeutic options for COVID-19 Preprint Screening	VERO cells			Mar/19/2020
Identification of Potent and Safe Antiviral Therapeutic Candidates Against SARS-CoV-2 Small molecule In vitro Screening	Vero cells	5.09		Nov/25/2020
In Silico Screening of Potential Spike Glycoprotein Inhibitors of SARS-CoV-2 with Drug Repurposing Strategy	in silico	1.55	In silico screening of potential virus spike protein inhibitors within a set of molecules including FDA aproved drugs and traditional chinese medicine compounds.	Aug/01/2020
Comparative analysis of antiviral efficacy of FDA-approved drugs against SARS-CoV-2 in human lung cells: Nafamostat is the most potent antiviral drug candidate Preprint	Calu-3 human airway epithelial cells		lower IC50 value in Calu-3 cells than VERO E6 cells	May/12/2020
Classical Drug Digitoxin Inhibits Influenza Cytokine Storm, With Implications for Covid-19 Therapy Cytokine storm Small molecule Animal model	cotton rats (influenza model only); influenza strain A/Wuhan/H3N2/359/95	1.54	Digitoxin suppresed cytokine storm in a rat influenza model, which according to the authors has implications for COVID-19 induced cytokine storm management.	Nov/01/2020
Repurposing of the approved small molecule drugs in order to inhibit SARS-CoV-2 S protein and human ACE2 interaction through virtual screening approaches Spike protein Small molecule In silico	in silico	3.22	Predicted to inhibit the SARS-CoV-2 spike protein binding to the host's ACE2 receptor.	Sep/24/2020

AI-suggested references

Link	Publication date
Molecular screening of glycyrrhizin-based inhibitors against ACE2 host receptor of SARS-CoV-2	Dec/07/2020
Leveraging knowledge of Asian herbal medicine and its active compounds as COVID-19 treatment and prevention	Nov/14/2020
Broad Spectrum Antiviral Properties of Cardiotonic Steroids Used as Potential Therapeutics for Emerging Coronavirus Infections	Oct/01/2020
Repurposing of the approved small molecule drugs in order to inhibit SARS-CoV-2 S protein and human ACE2 interaction through virtual screening approaches	Nov/01/2020
Common cardiac medications potently inhibit ACE2 binding to the SARS-CoV-2 Spike, and block virus penetration and infectivity in human lung cells	Nov/12/2021

Export (.csv)