Other substances

10-hydroxyusambarensine

An alkaloid.

Phase of research

Potential treatment - theoretical effect

How it helps

Antiviral

Drug status

Natural product

1
 Supporting references
0
 Contradictory references
2
 AI-suggested references
0
 Clinical trials

General information

10-hydroxyusambarensine on PubChem

Synonyms

1-[[(2R,3E,12Bs)-3-ethylidene-2,4,6,7,12,12b-hexahydro-1H-indolo[2,3-a]quinolizin-2-yl]methyl]-9H-pyrido[3,4-b]indol-6-ol

 

Structure image - 10-hydroxyusambarensine

C/C=C\1/CN2CCC3=C([C@@H]2C[C@@H]1CC4=NC=CC5=C4NC6=C5C=C(C=C6)O)NC7=CC=CC=C37

Supporting references

Link Tested on Impact factor Notes Publication date
Prevention of SARS-CoV-2 cell entry: insight from in silico interaction of drug-like alkaloids with spike glycoprotein, human ACE2, and TMPRSS2
TMPRSS2 Small molecule In silico 		in silico 3.22

Predicted to bind the host TMPRSS2 protease.

 Oct/22/2020

AI-suggested references

Link Publication date
Potential inhibitors of coronavirus 3-chymotrypsin-like protease (3CLpro): an in silico screening of alkaloids and terpenoids from African medicinal plants
Dec/07/2021
African derived phytocompounds may interfere with SARS-CoV-2 RNA capping machinery via inhibition of 2'-O-ribose methyltransferase: an in silico perspective.
Apr/12/2022
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