1-{3-[2-Hydroxy-3-(4-methylpiperidino)propoxy]phenoxy}-3-(4-methylpiperidino)-2-propanol
General information
1-{3-[2-Hydroxy-3-(4-methylpiperidino)propoxy]phenoxy}-3-(4-methylpiperidino)-2-propanol has been reported to possess anti-SARS-CoV-2 activity in vitro (He et al., 2021).
1-{3-[2-Hydroxy-3-(4-methylpiperidino)propoxy]phenoxy}-3-(4-methylpiperidino)-2-propanol on PubChem
Synonyms
SC171
CC1CCN(CC1)CC(COC2=CC(=CC=C2)OCC(CN3CCC(CC3)C)O)O
Supporting references
Link | Tested on | Impact factor | Notes | Publication date |
---|---|---|---|---|
Identification of bis-benzylisoquinoline alkaloids as SARS-CoV-2 entry inhibitors from a library of natural products
Small molecule In vitro Mechanism |
in vitro binding assay; 293T-ACE2 cells; Calu-3 cells; A549 cells; Vero E6 cells; (HIV-1) SARS-CoV-2 Spike (D614/G614/B.1.1.7/B.1.351); SARS-CoV-2 live virus | 13.49 | The compound inhibited lentiviral SARS-CoV-2 Spike-pseudotyped virus infection in 293T-ACE2 (EC50 of 3.83 μM or lower, SI >13), Calu-3 and A549 cells. It displayed efficacy also against pseudoviruses with Spike protein of G614, B.1.1.7, B.1.351, SARS, and MERS viruses/strains. The experimental findings suggest that the compound blocks coronavirus entry into host cells by inhibition of calcium ion channels. The compound was also shown to protect Vero E6 cells from SARS-CoV-2 live virus-induced cytopathogenic effect. |
Mar/23/2021 |