Other substances

(-)-Gallocatechin gallate

A catechin.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Natural product

Supporting references

Contradictory references

AI-suggested references

Clinical trials

General information

(-)-Gallocatechin gallate is a green tea polyphenol. It was shown to disrupt liquid–liquid phase separation of SARS-CoV-2 Nucleocapsid protein and inhibit viral replication in vitro (Zhao et al., 2021).

(-)-Gallocatechin gallate on PubChem

Synonyms

GCG

Structure image - (-)-Gallocatechin gallate

Supporting references

Link	Tested on	Impact factor	Notes	Publication date
GCG inhibits SARS-CoV-2 replication by disrupting the liquid phase condensation of its nucleocapsid protein. Spike protein ACE2 Nucleocapsid protein Small molecule In vitro Mechanism	in vitro binding assay; A549-hACE2-Flag cells; SARS-CoV-2 strain nCoV-SH01	12.12	The compound was shown to disrupt liquid–liquid phase separation of SARS-CoV-2 Nucleocapsid protein and inhibit viral replication with an IC50 of 44,4 μM and an SI of 3.5 in vitro.	Apr/09/2021

AI-suggested references

Link	Publication date
GLP-1 Mediates Regulation of Colonic ACE2 Expression by the Bile Acid Receptor GPBAR1 in Inflammation.	Apr/01/2022
Antiviral Effects of Green Tea EGCG and Its Potential Application against COVID-19	Apr/11/2021
Discovery of Camellia sinensis catechins as SARS-CoV-2 3CL protease inhibitors through molecular docking, intra and extra cellular assays.	Nov/09/2021
GCG inhibits SARS-CoV-2 replication by disrupting the liquid phase condensation of its nucleocapsid protein	Apr/09/2021
Docking Characterization and in vitro Inhibitory Activity of Flavan-3-ols and Dimeric Proanthocyanidins Against the Main Protease Activity of SARS-Cov-2	Nov/30/2020

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