Other substances

(-)-Epicatechin

An antioxidant flavonoid.

Phase of research

Potential treatment - theoretical effect

How it helps

Antiviral

Drug status

Natural product

Supporting references

Contradictory references

AI-suggested references

Clinical trials

General information

Epicatechin on PubChem

Synonyms

Epicatechin

Structure image - (-)-Epicatechin

C1[C@H]([C@H](OC2=CC(=CC(=C21)O)O)C3=CC(=C(C=C3)O)O)O

Supporting references

Link	Tested on	Impact factor	Notes	Publication date
An in-silico evaluation of dietary components for structural inhibition of SARS-Cov-2 main protease 3CLpro Small molecule In silico	in silico	3.31	Predicted to inhibit SARS-CoV-2 3C-like protease.	Aug/18/2020
Secondary metabolites from spice and herbs as potential multitarget inhibitors of SARS-CoV-2 proteins Small molecule In silico	in silico	3.22	Predicted to bind to multiple SARS-CoV-2 viral proteins.	Oct/27/2020
In silico analysis of the interactions of certain flavonoids with the receptor-binding domain of 2019 novel coronavirus and cellular proteases and their pharmacokinetic properties Spike protein TMPRSS2 Cathepsin B Cathepsin L Small molecule In silico	in silico	3.22	Predicted to bind the SARS-CoV-2 spike protein RBD and the host TMPRSS2, cathepsin B, and cathepsin L proteases.	Oct/28/2020

AI-suggested references

Link	Publication date
Phytochemical rich Himalayan Rhododendron arboreum petals inhibit SARS-CoV-2 infection in vitro.	Dec/28/2021
Flavan-based phytoconstituents inhibit Mpro, a SARS-COV-2 molecular target, in silico.	Aug/04/2021
Study on the mechanism of active components of Liupao tea on 3CLpro based on HPLC-DAD fingerprint and molecular docking technique.	Jul/05/2021
Potential Inhibitors of SARS-CoV-2 from Neocarya macrophylla (Sabine) Prance ex F. White: Chemoinformatic and Molecular Modeling Studies for Three Key Targets	Jun/05/2022
Discovery of Camellia sinensis catechins as SARS-CoV-2 3CL protease inhibitors through molecular docking, intra and extra cellular assays.	Nov/09/2021
Reynoutria Rhizomes as a Natural Source of SARS-CoV-2 Mpro Inhibitors-Molecular Docking and In Vitro Study	Jul/29/2021
Novel antiviral effects of chloroquine, hydroxychloroquine, and green tea catechins against SARS-CoV-2 main protease and 3C-like protease for COVID-19 treatment	Sep/13/2021
Epicatechin is a promising novel inhibitor of SARS-CoV-2 entry by disrupting interactions between angiotensin-converting enzyme type 2 and the viral receptor binding domain: A computational/simulation study.	Dec/17/2021
Identification of potential plant-based inhibitor against viral proteases of SARS-CoV-2 through molecular docking, MM-PBSA binding energy calculations and molecular dynamics simulation.	Apr/15/2021
Docking Characterization and in vitro Inhibitory Activity of Flavan-3-ols and Dimeric Proanthocyanidins Against the Main Protease Activity of SARS-Cov-2	Nov/30/2020
SARS-CoV-2 neutralizing activity of polyphenols in a special green tea extract preparation	Jun/22/2020
Plant-Based Phytochemical Screening by Targeting Main Protease of SARS-CoV-2 to Design Effective Potent Inhibitors	Jul/24/2020
Green Tea Polyphenol Catechins Inhibit Coronavirus Replication and Potentiate the Adaptive Immunity and Autophagy-Dependent Protective Mechanism to Improve Acute Lung Injury in Mice.	Jun/07/2021
Anti-SARS-CoV-2 activity of various PET-bottled Japanese green teas and tea compounds in vitro	May/24/2022
Characterization of the Trans-Epithelial Transport of Green Tea (C. sinensis) Catechin Extracts with In Vitro Inhibitory Effect against the SARS-CoV-2 Papain-like Protease Activity	Nov/08/2021
Bioactive Molecules of Tea as Potential Inhibitors for RNA-Dependent RNA Polymerase of SARS-CoV-2.	May/31/2021
Flavonoids as potential phytotherapeutics to combat cytokine storm in SARS-CoV-2	Mar/29/2020